WTAPP1 WTAP pseudogene 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: WTAPP1provided by HGNC
Official Full Name: WTAP pseudogene 1provided by HGNC
Primary source: HGNC:HGNC:44115
See related: Ensembl:ENSG00000293047 AllianceGenome:HGNC:44115
Gene type: pseudo
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression: Biased expression in gall bladder (RPKM 3.0), appendix (RPKM 1.1) and 8 other tissues See more
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Genomic context

Location:: 11q22.2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (102783676..102836766)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (102787488..102840535)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (102654407..102707497)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

N(6) -methyladenosine-Mediated Upregulation of WTAPP1 Promotes WTAP Translation and Wnt Signaling to Facilitate Pancreatic Cancer Progression.
Title: N(6) -methyladenosine-Mediated Upregulation of WTAPP1 Promotes WTAP Translation and Wnt Signaling to Facilitate Pancreatic Cancer Progression.
LncRNA WTAPP1 promotes proliferation of laryngeal carcinoma cells through regulating microRNA-592.
Title: LncRNA WTAPP1 promotes proliferation of laryngeal carcinoma cells through regulating microRNA-592.
LncRNA WTAPP1 promotes cancer cell invasion and migration in NSCLC by downregulating lncRNA HAND2-AS1.
Title: LncRNA WTAPP1 promotes cancer cell invasion and migration in NSCLC by downregulating lncRNA HAND2-AS1.
The lncRNA WTAPP1, a molecular decoy for miR-3120-5p, regulates MMP-1 expression via the PI3K/Akt and autophagy pathways, thereby mediating cell migration and angiogenesis in EPCs.
Title: LncRNA WTAPP1 Promotes Migration and Angiogenesis of Endothelial Progenitor Cells via MMP1 Through MicroRNA 3120 and Akt/PI3K/Autophagy Pathways.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association scan identifies variants near Matrix Metalloproteinase (MMP) genes on chromosome 11q21-22 strongly associated with serum MMP-1 levels. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

MMP3_2663 (e-PCR)
- UniSTS:462347

MMP1 (e-PCR)
- UniSTS:273431

PMC65699P1 (e-PCR)
- UniSTS:273431

G54104 (e-PCR)
- UniSTS:109341

MMP1 (e-PCR)
- UniSTS:253988

MMP1 (e-PCR)
- UniSTS:6181

PMC85083P2 (e-PCR)
- UniSTS:273464

PMC151710P3 (e-PCR)
- UniSTS:271169

PMC151710P4 (e-PCR)
- UniSTS:271170

GDB:197898 (e-PCR)
- UniSTS:155992

SHGC-82595 (e-PCR)
- UniSTS:100717

D14S1188 (e-PCR)
- UniSTS:74617

STS-X05232 (e-PCR)
- UniSTS:24219

SHGC-11954 (e-PCR)
- UniSTS:21418

PMC125702P3 (e-PCR)
- UniSTS:270509

PMC125702P5 (e-PCR)
- UniSTS:270511

NoName (e-PCR)
- UniSTS:99779

RH17661 (e-PCR)
- UniSTS:47569

Other Names

Wilms tumor 1 associated protein pseudogene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.