LINC00941 long intergenic non-protein coding RNA 941 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LINC00941provided by HGNC
Official Full Name: long intergenic non-protein coding RNA 941provided by HGNC
Primary source: HGNC:HGNC:48635
See related: Ensembl:ENSG00000285517 MIM:620799; AllianceGenome:HGNC:48635
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: lncIAPF; lncRNA-MUF
Summary: Enables promoter-enhancer loop anchoring activity. Involved in chromatin looping and positive regulation of transcription by RNA polymerase II. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 12p11.21

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (30795681..30802711)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (30670302..30677329)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (30948615..30955645)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Linc00941 fuels ribogenesis and protein synthesis by supporting robust cMYC translation in malignant pleural mesothelioma.
Title: Linc00941 fuels ribogenesis and protein synthesis by supporting robust cMYC translation in malignant pleural mesothelioma.
lncRNA LINC00941 modulates MTA2/NuRD occupancy to suppress premature human epidermal differentiation.
Title: lncRNA LINC00941 modulates MTA2/NuRD occupancy to suppress premature human epidermal differentiation.
LINC00941: a novel player involved in the progression of human cancers.
Title: LINC00941: a novel player involved in the progression of human cancers.
The human long non-coding RNA LINC00941 and its modes of action in health and disease.
Title: The human long non-coding RNA LINC00941 and its modes of action in health and disease.
Knockdown of long non-coding RNA LINC00941 suppressed cell proliferation, colony-formation, and migration of human glioblastoma cell lines.
Title: Knockdown of long non-coding RNA LINC00941 suppressed cell proliferation, colony-formation, and migration of human glioblastoma cell lines.
Reciprocal regulation of LINC00941 and SOX2 promotes progression of esophageal squamous cell carcinoma.
Title: Reciprocal regulation of LINC00941 and SOX2 promotes progression of esophageal squamous cell carcinoma.
Long non-coding RNA-LINC00941 promotes the proliferation and invasiveness of glioma cells.
Title: Long non-coding RNA-LINC00941 promotes the proliferation and invasiveness of glioma cells.
ATF3 -activated accelerating effect of LINC00941/lncIAPF on fibroblast-to-myofibroblast differentiation by blocking autophagy depending on ELAVL1/HuR in pulmonary fibrosis.
Title: ATF3 -activated accelerating effect of LINC00941/lncIAPF on fibroblast-to-myofibroblast differentiation by blocking autophagy depending on ELAVL1/HuR in pulmonary fibrosis.
Long Noncoding RNA LINC00941 Promotes Cell Proliferation and Invasion by Interacting with hnRNPK in Oral Squamous Cell Carcinoma.
Title: Long Noncoding RNA LINC00941 Promotes Cell Proliferation and Invasion by Interacting with hnRNPK in Oral Squamous Cell Carcinoma.
Expression changes of serum LINC00941 and LINC00514 in HBV infection-related liver diseases and their potential application values.
Title: Expression changes of serum LINC00941 and LINC00514 in HBV infection-related liver diseases and their potential application values.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:9484

D8S2279 (e-PCR)
- UniSTS:473907

Other Names

MSC upregulated factor
lncRNA Inhibit Autophagy in Pulmonary Fibrogenesis

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables promoter-enhancer loop anchoring activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin looping	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.