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epha4 EPH receptor A4 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 100216124, updated on 4-Nov-2024

Summary

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Official Symbol
epha4provided by Xenbase
Official Full Name
EPH receptor A4provided by Xenbase
Primary source
Xenbase:XB-GENE-1015803
See related
Ensembl:ENSXETG00000007614 AllianceGenome:Xenbase:XB-GENE-1015803
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
Pag; sek; hek8; rtk1; sek-1; tyr01; XEpha4; eph-a4; epha4-a; epha4-b; Pagliaccio
Summary
Predicted to enable ATP binding activity and ephrin receptor activity. Predicted to act upstream of or within cell surface receptor protein tyrosine kinase signaling pathway; nervous system development; and protein phosphorylation. Predicted to be located in early endosome and plasma membrane. Is expressed in anatomical system; mesenchyme; pharyngeal arch; and primary germ layer. Orthologous to human EPHA4 (EPH receptor A4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See epha4 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
19
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 5 NC_030681.2 (124743510..124791905, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 5 NC_030681.1 (121186956..121235356, complement)

Chromosome 5 - NC_030681.2Genomic Context describing neighboring genes Neighboring gene putative serine protease K12H4.7 Neighboring gene serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 Neighboring gene uncharacterized LOC101732582 Neighboring gene uncharacterized LOC100491450

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ephrin type-A receptor 4
NP_001135575.1
XP_012825631.1
XP_012825633.1
XP_017949298.1
XP_017949299.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142103.1 → NP_001135575.1  ephrin type-A receptor 4 precursor

    See identical proteins and their annotated locations for NP_001135575.1

    Status: PROVISIONAL

    Source sequence(s)
    BC168080
    UniProtKB/TrEMBL
    A0A6I8S528, B4F704
    Related
    ENSXETP00000078835.1, ENSXETT00000076065.2
    Conserved Domains (5) summary
    cd09545
    Location:910 → 980
    SAM_EPH-A4; SAM domain of EPH-A4 subfamily of tyrosine kinase receptors
    cd10482
    Location:30 → 203
    EphR_LBD_A4; Ligand Binding Domain of Ephrin type-A Receptor 4
    cd00063
    Location:440 → 531
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:615 → 880
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam14575
    Location:551 → 615
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030681.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    124743510..124791905 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012970179.3 → XP_012825633.1  ephrin type-A receptor 4 isoform X3

    UniProtKB/TrEMBL
    A0A6I8S528, A0A8J0SWZ8
    Related
    ENSXETP00000091900.1, ENSXETT00000086523.2
    Conserved Domains (7) summary
    cd09545
    Location:910 → 980
    SAM_EPH-A4; SAM domain of EPH-A4 subfamily of tyrosine kinase receptors
    smart00454
    Location:907 → 974
    SAM; Sterile alpha motif
    cd10482
    Location:30 → 203
    EphR_LBD_A4; Ligand Binding Domain of Ephrin type-A Receptor 4
    cd00063
    Location:440 → 531
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:615 → 881
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam07714
    Location:620 → 877
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:551 → 615
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

  2. XM_012970177.2 → XP_012825631.1  ephrin type-A receptor 4 isoform X1

    UniProtKB/TrEMBL
    A0A6I8S528, F6QKP3
    Related
    ENSXETP00000016595.4, ENSXETT00000016595.5
    Conserved Domains (5) summary
    cd09545
    Location:911 → 981
    SAM_EPH-A4; SAM domain of EPH-A4 subfamily of tyrosine kinase receptors
    cd10482
    Location:30 → 203
    EphR_LBD_A4; Ligand Binding Domain of Ephrin type-A Receptor 4
    cd00063
    Location:440 → 531
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:615 → 881
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam14575
    Location:551 → 615
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

  3. XM_018093809.2 → XP_017949298.1  ephrin type-A receptor 4 isoform X2

    UniProtKB/TrEMBL
    A0A6I8S528, A0A8J0T400

  4. XM_018093810.2 → XP_017949299.1  ephrin type-A receptor 4 isoform X4

    UniProtKB/TrEMBL
    A0A6I8S528, A0A8J0T0R8
Nucleotide Protein Strain
Heading Accession and Version

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