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btk Bruton tyrosine kinase [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 100170477, updated on 18-Sep-2024

Summary

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Official Symbol
btkprovided by Xenbase
Official Full Name
Bruton tyrosine kinaseprovided by Xenbase
Primary source
Xenbase:XB-GENE-6451230
See related
Ensembl:ENSXETG00000018152
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
atk; bpk; xla; imd1; agmx1; psctk1
Orthologs
human mouse all
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Genomic context

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See btk in Genome Data Viewer
Location:
chromosome: 8
Exon count:
20
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 8 NC_030684.2 (37636934..37676734)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 8 NC_030684.1 (17041675..17080460)

Chromosome 8 - NC_030684.2Genomic Context describing neighboring genes Neighboring gene galactosidase alpha Neighboring gene ribosomal protein L36a Neighboring gene MGC108429 protein Neighboring gene translocase of inner mitochondrial membrane 8A Neighboring gene TATA-box binding protein associated factor 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tyrosine-protein kinase BTK
Names
Bruton agammaglobulinemia tyrosine kinase
NP_001123732.1
XP_031746104.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130260.1 → NP_001123732.1  tyrosine-protein kinase BTK

    See identical proteins and their annotated locations for NP_001123732.1

    Status: PROVISIONAL

    Source sequence(s)
    BC167379
    UniProtKB/TrEMBL
    A0A6I8QLG6, A0A6I8QNH2, A0A6I8RDH6, A0A6I8RIC8, A0A6I8SYX0, A0A6I8SZD2, B3DLB1, F6V9R3, F6ZG23
    Related
    ENSXETP00000083037.2, ENSXETT00000099655.2
    Conserved Domains (4) summary
    cd10397
    Location:267 → 370
    SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)
    cd11906
    Location:209 → 264
    SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase
    cd01238
    Location:8 → 167
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    cl21453
    Location:388 → 638
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030684.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    37636934..37676734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_031890244.1 → XP_031746104.1  tyrosine-protein kinase BTK isoform X1

    UniProtKB/TrEMBL
    A0A6I8QLG6, A0A6I8QNH2, A0A6I8RDH6, A0A6I8RIC8, A0A6I8SYX0, A0A6I8SZD2, B3DLB1, F6V9R3, F6ZG23
    Related
    ENSXETP00000102157.1, ENSXETT00000108943.1
    Conserved Domains (4) summary
    cd10397
    Location:267 → 370
    SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)
    cd11906
    Location:209 → 264
    SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase
    cd01238
    Location:8 → 167
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    cl21453
    Location:388 → 638
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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