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fgd5a FYVE, RhoGEF and PH domain containing 5a [ Danio rerio (zebrafish) ]

Gene ID: 100151562, updated on 12-Sep-2024

Summary

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Official Symbol
fgd5aprovided by ZNC
Official Full Name
FYVE, RhoGEF and PH domain containing 5aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-090428-3
See related
Ensembl:ENSDARG00000088801 AllianceGenome:ZFIN:ZDB-GENE-090428-3
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and metal ion binding activity. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Is expressed in blood island; cranial vasculature; and trunk vasculature. Orthologous to human FGD5 (FYVE, RhoGEF and PH domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See fgd5a in Genome Data Viewer
Location:
chromosome: 11
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (18396148..18468568, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (18236342..18306210, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene Scm like with four mbt domains 1 Neighboring gene protein kinase C, delta b Neighboring gene death inducer-obliterator 1 Neighboring gene zinc finger, MYND-type containing 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cdc42 mediates Bmp-induced sprouting angiogenesis through Fmnl3-driven assembly of endothelial filopodia in zebrafish. Wakayama Y, et al. Dev Cell, 2015 Jan 12. PMID 25584797
  2. Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish. Xiao A, et al. Nucleic Acids Res, 2013 Aug. PMID 23748566, Free PMC Article
  3. G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition. Zhang P, et al. Cell Res, 2015 Oct. PMID 26358189, Free PMC Article
  4. Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish. Kok FO, et al. Dev Cell, 2015 Jan 12. PMID 25533206, Free PMC Article
  5. Discovery and characterization of novel vascular and hematopoietic genes downstream of etsrp in zebrafish. Gomez GA, et al. PLoS One, 2009. PMID 19308258, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
FYVE, RhoGEF and PH domain-containing protein 5
Names
fgd5
zmp:0000000940

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    18396148..18468568 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021479796.2 → XP_021335471.1  FYVE, RhoGEF and PH domain-containing protein 5 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B1Z4
    Conserved Domains (5) summary
    smart00325
    Location:919 → 1103
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd15792
    Location:1121 → 1243
    PH1_FGD5; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 5, N-terminal Pleckstrin Homology (PH) domain
    cd15742
    Location:1255 → 1321
    FYVE_FGD5; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 5 (FGD5) and similar proteins
    cl17171
    Location:1377 → 1458
    PH-like; Pleckstrin homology-like domain
    cl28246
    Location:25 → 149
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

  2. XM_021479795.2 → XP_021335470.1  FYVE, RhoGEF and PH domain-containing protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QLY3, X1WDS7
    Related
    ENSDARP00000128376.2, ENSDART00000155474.3
    Conserved Domains (5) summary
    smart00325
    Location:919 → 1103
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13237
    Location:1377 → 1467
    PH2_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6 pleckstrin homology (PH) domain, C-terminus
    cd15792
    Location:1121 → 1243
    PH1_FGD5; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 5, N-terminal Pleckstrin Homology (PH) domain
    cd15742
    Location:1255 → 1321
    FYVE_FGD5; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 5 (FGD5) and similar proteins
    cl28246
    Location:25 → 149
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394814.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    313439..383148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001919859.7 → XP_001919894.2  FYVE, RhoGEF and PH domain-containing protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QLY3, X1WDS7
    Conserved Domains (5) summary
    smart00325
    Location:919 → 1103
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13237
    Location:1377 → 1467
    PH2_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6 pleckstrin homology (PH) domain, C-terminus
    cd15792
    Location:1121 → 1243
    PH1_FGD5; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 5, N-terminal Pleckstrin Homology (PH) domain
    cd15742
    Location:1255 → 1321
    FYVE_FGD5; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 5 (FGD5) and similar proteins
    cl28246
    Location:25 → 149
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

  2. XM_005155840.5 → XP_005155897.1  FYVE, RhoGEF and PH domain-containing protein 5 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B1Z4
    Conserved Domains (5) summary
    smart00325
    Location:919 → 1103
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd15792
    Location:1121 → 1243
    PH1_FGD5; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 5, N-terminal Pleckstrin Homology (PH) domain
    cd15742
    Location:1255 → 1321
    FYVE_FGD5; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 5 (FGD5) and similar proteins
    cl17171
    Location:1377 → 1458
    PH-like; Pleckstrin homology-like domain
    cl28246
    Location:25 → 149
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein Strain
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