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kpna6 karyopherin alpha 6 (importin alpha 7) [ Danio rerio (zebrafish) ]

Gene ID: 100149852, updated on 2-Nov-2024

Summary

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Official Symbol
kpna6provided by ZNC
Official Full Name
karyopherin alpha 6 (importin alpha 7)provided by ZNC
Primary source
ZFIN:ZDB-GENE-130530-626
See related
Ensembl:ENSDARG00000044980 AllianceGenome:ZFIN:ZDB-GENE-130530-626
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable nuclear import signal receptor activity. Predicted to be involved in animal organ development. Predicted to act upstream of or within protein import into nucleus. Predicted to be located in cytoplasm. Orthologous to human KPNA6 (karyopherin subunit alpha 6). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See kpna6 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (29861854..29887644, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (30278405..30300384, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene si:ch73-130a3.4 Neighboring gene taxilin alpha Neighboring gene uncharacterized LOC137488528 Neighboring gene KH domain containing, RNA binding, signal transduction associated 1b Neighboring gene tetraspanin 13b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolutionary and Expression Analyses Show Co-option of khdrbs Genes for Origin of Vertebrate Brain. Wang S, et al. Front Genet, 2017. PMID 29354154, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables nuclear import signal receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in animal organ development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein import into nucleus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
importin subunit alpha-7
Names
zmp:0000000623

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    29861854..29887644 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001923886.7 → XP_001923921.1  importin subunit alpha-7

    UniProtKB/TrEMBL
    A0A8M1QRD2, E7F7U9
    Related
    ENSDARP00000066122.5, ENSDART00000066123.7
    Conserved Domains (5) summary
    COG5064
    Location:36 → 536
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00020
    Location:252 → 366
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam01749
    Location:9 → 103
    IBB; Importin beta binding domain
    pfam16186
    Location:465 → 511
    Arm_3; Atypical Arm repeat
    sd00043
    Location:255 → 280
    ARM; armadillo repeat [structural motif]
Nucleotide Protein
Heading Accession and Version

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