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tyms.L thymidylate synthetase L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 100125228, updated on 4-Nov-2024

Summary

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Official Symbol
tyms.L
Official Full Name
thymidylate synthetase L homeolog
Primary source
Xenbase:XB-GENE-1001390
Locus tag
XELAEV_18031891mg
See related
EnsemblRapid:ENSXLAG00005025572 AllianceGenome:Xenbase:XB-GENE-1001390
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
ts; tyms
Summary
Predicted to enable thymidylate synthase activity. Predicted to act upstream of or within dTMP biosynthetic process; dTTP biosynthetic process; and methylation. Predicted to be located in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; cerebral infarction; gastrointestinal system cancer (multiple); hematologic cancer (multiple); and rheumatoid arthritis. Orthologous to human TYMS (thymidylate synthetase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tyms.L in Genome Data Viewer
Location:
chromosome: 6L
Exon count:
8
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 6L NC_054381.1 (115036707..115053264, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 6L NC_030734.1 (107953894..107970237, complement)

Chromosome 6L - NC_054381.1Genomic Context describing neighboring genes Neighboring gene adenylate cyclase activating polypeptide 1 (pituitary) L homeolog Neighboring gene YES proto-oncogene 1, Src family tyrosine kinase L homeolog Neighboring gene clusterin like 1 L homeolog Neighboring gene collectin subfamily member 12 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC160415

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables thymidylate synthase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within dTMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within dTTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
thymidylate synthase
NP_001096659.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001103189.1 → NP_001096659.1  thymidylate synthase

    See identical proteins and their annotated locations for NP_001096659.1

    Status: PROVISIONAL

    Source sequence(s)
    BC129727
    UniProtKB/TrEMBL
    A0A974CNF8, A1L2V6
    Related
    ENSXLAP00005076101.1, ENSXLAT00005077681.1
    Conserved Domains (1) summary
    pfam00303
    Location:28 → 309
    Thymidylat_synt; Thymidylate synthase

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054381.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    115036707..115053264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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