fas Fas cell surface death receptor [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: fasprovided by Xenbase
Official Full Name: Fas cell surface death receptorprovided by Xenbase
Primary source: Xenbase:XB-GENE-940178
See related: Ensembl:ENSXETG00000031916 AllianceGenome:Xenbase:XB-GENE-940178
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: apt1; cd95; fas1; apo-1; fastm; alps1a; tnfrsf6
Summary: Predicted to enable calmodulin binding activity and transmembrane signaling receptor activity. Predicted to act upstream of or within several processes, including apoptotic process; immune response; and regulation of apoptotic process. Predicted to be located in cell surface; membrane raft; and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic cancer (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	7	NC_030683.2 (12681897..12706965, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	7	NC_030683.1 (4446095..4468139, complement)

Chromosome 7 - NC_030683.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 6

Names: Fas (TNF receptor superfamily, member 6)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001102729.1 → NP_001096199.1 tumor necrosis factor receptor superfamily member 6 precursor

See identical proteins and their annotated locations for NP_001096199.1

Status: PROVISIONAL

Source sequence(s)

EF555573

UniProtKB/TrEMBL

A0A6I8PTW1, A5JPX1

Related

ENSXETP00000058389.2, ENSXETT00000060786.3

Conserved Domains (2) summary

cd08316
Location:227 → 319

Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6

cd10579
Location:41 → 175

TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030683.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

12681897..12706965 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_012965876.3 → XP_012821330.2 tumor necrosis factor receptor superfamily member 6 isoform X1

UniProtKB/TrEMBL

A0A6I8PTW1, A0A6I8SQL5, B7ZU83

Related

ENSXETP00000100597.2, ENSXETT00000096944.2

Conserved Domains (2) summary

cd10579
Location:41 → 175

TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)

cl14633
Location:218 → 310

DD; Death Domain Superfamily of protein-protein interaction domains