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rasgrp1 RAS guanyl releasing protein 1 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 100101791, updated on 4-Nov-2024

Summary

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Official Symbol
rasgrp1provided by Xenbase
Official Full Name
RAS guanyl releasing protein 1provided by Xenbase
Primary source
Xenbase:XB-GENE-489811
See related
Ensembl:ENSXETG00000018074 AllianceGenome:Xenbase:XB-GENE-489811
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
rasgrp; hrasgrp1
Summary
Predicted to enable calcium ion binding activity and guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within cell differentiation and small GTPase-mediated signal transduction. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in immunodeficiency 64. Orthologous to human RASGRP1 (RAS guanyl releasing protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See rasgrp1 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
19
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 8 NC_030684.2 (110699223..110760617)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 8 NC_030684.1 (90432071..90470305)

Chromosome 8 - NC_030684.2Genomic Context describing neighboring genes Neighboring gene secretogranin V Neighboring gene Rho GTPase activating protein 11A, gene 1 Neighboring gene decreased expression in renal and prostate cancer protein-like Neighboring gene family with sequence similarity 98 member B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RAS guanyl-releasing protein 1
Names
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
caldag-gefi
caldag-gefii

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100278.2 → NP_001093748.2  RAS guanyl-releasing protein 1

    Status: VALIDATED

    Source sequence(s)
    AAMC04000008
    UniProtKB/Swiss-Prot
    A4IJ06
    UniProtKB/TrEMBL
    A0A6I8PW37
    Related
    ENSXETP00000063742.3, ENSXETT00000063778.3
    Conserved Domains (5) summary
    cd06224
    Location:77 → 193
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00338
    Location:744 → 799
    BRLZ; basic region leucin zipper
    smart00147
    Location:217 → 453
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    pfam00130
    Location:558 → 607
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13499
    Location:494 → 543
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030684.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    110699223..110760617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_031906824.1 → XP_031762684.1  RAS guanyl-releasing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A4IJ06
    UniProtKB/TrEMBL
    A0A8J0SUK8
    Conserved Domains (5) summary
    cd06224
    Location:12 → 128
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:152 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    pfam13499
    Location:429 → 478
    EF-hand_7; EF-hand domain pair
    cd20860
    Location:491 → 545
    C1_RASGRP1; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 1 (RASGRP1) and similar proteins
    cd22290
    Location:688 → 742
    cc_RasGRP1_C; C-terminal coiled-coil domain of RAS guanyl-releasing protein 1 (RasGRP1) and similar proteins

  2. XM_012967847.3 → XP_012823301.1  RAS guanyl-releasing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A4IJ06
    UniProtKB/TrEMBL
    A0A8J0SUK8
    Related
    ENSXETP00000039215.3, ENSXETT00000039215.4
    Conserved Domains (5) summary
    cd06224
    Location:12 → 128
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:152 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    pfam13499
    Location:429 → 478
    EF-hand_7; EF-hand domain pair
    cd20860
    Location:491 → 545
    C1_RASGRP1; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 1 (RASGRP1) and similar proteins
    cd22290
    Location:688 → 742
    cc_RasGRP1_C; C-terminal coiled-coil domain of RAS guanyl-releasing protein 1 (RasGRP1) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4IJ06.1 GenPept UniProtKB/Swiss-Prot:A4IJ06

Gene LinkOut

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