six6 SIX homeobox 6 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: six6provided by Xenbase
Official Full Name: SIX homeobox 6provided by Xenbase
Primary source: Xenbase:XB-GENE-483146
See related: Ensembl:ENSXETG00000016945 AllianceGenome:Xenbase:XB-GENE-483146
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: hpe2; six9; XSix3; optx2; xSix6; Six6.1; Six6.2; XOptx2; six3.2; XSix6.1; mcopct2; xsix6.2
Summary: Predicted to enable DNA binding activity. Predicted to be located in nucleus. Is expressed in nervous system and visual system. Human ortholog(s) of this gene implicated in optic disc anomalies with retinal and/or macular dystrophy. Orthologous to human SIX6 (SIX homeobox 6). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	8	NC_030684.2 (102517518..102520551, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	8	NC_030684.1 (82247568..82250601, complement)

Chromosome 8 - NC_030684.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein SIX6

Names: optic six gene 2; sine oculis homeobox homolog 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100226.1 → NP_001093696.1 homeobox protein SIX6

See identical proteins and their annotated locations for NP_001093696.1

Status: PROVISIONAL

Source sequence(s)

BC135852

UniProtKB/TrEMBL

A4II51, F6Y0D4

Related

ENSXETP00000036923.4, ENSXETT00000036923.5

Conserved Domains (2) summary

cd00086
Location:130 → 178

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

pfam16878
Location:9 → 122

SIX1_SD; Transcriptional regulator, SIX1, N-terminal SD domain