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Nhsl2 NHS like 2 [ Mus musculus (house mouse) ]

Gene ID: 100042480, updated on 2-Nov-2024

Summary

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Official Symbol
Nhsl2provided by MGI
Official Full Name
NHS like 2provided by MGI
Primary source
MGI:MGI:3645090
See related
Ensembl:ENSMUSG00000079481 AllianceGenome:MGI:3645090
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm10456; EG621083; 6430511F03; 1110062M06Rik
Summary
Predicted to be involved in cell differentiation. Orthologous to human NHSL2 (NHS like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cerebellum adult (RPKM 2.1), bladder adult (RPKM 1.8) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Nhsl2 in Genome Data Viewer
Location:
X D; X 44.75 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (100892942..101135661)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (101849261..102092055)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene H3.3 histone A, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_47663 Neighboring gene predicted gene 3858 Neighboring gene STARR-seq mESC enhancer starr_47664 Neighboring gene predicted gene, 25828 Neighboring gene STARR-seq mESC enhancer starr_47665 Neighboring gene STARR-seq mESC enhancer starr_47666 Neighboring gene retrotransposon Gag like 5 Neighboring gene STARR-positive B cell enhancer ABC_E5732 Neighboring gene high mobility group protein B1 pseudogene Neighboring gene peptidyl-prolyl cis/trans isomerase, NIMA-interacting, 4 (parvulin)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
  2. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
NHS-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163610.2 → NP_001157082.1  NHS-like protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL807784, AL808026
    Consensus CDS
    CCDS53156.1
    UniProtKB/Swiss-Prot
    B1AXH1, E9Q0V6
    Related
    ENSMUSP00000098893.5, ENSMUST00000101339.8
    Conserved Domains (1) summary
    pfam15273
    Location:623 → 755
    NHS; NHS-like

  2. NM_001406043.1 → NP_001392972.1  NHS-like protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL807784, AL808026

  3. NM_001406044.1 → NP_001392973.1  NHS-like protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL807784, AL808026

  4. NM_001406045.1 → NP_001392974.1  NHS-like protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL807784, AL808026

  5. NM_001406046.1 → NP_001392975.1  NHS-like protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL807784, AL808026

  6. NM_001406047.1 → NP_001392976.1  NHS-like protein 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL807784, AL808026

  7. NM_001406048.1 → NP_001392977.1  NHS-like protein 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL807784, AL808026

  8. NM_001406049.1 → NP_001392978.1  NHS-like protein 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL807784, AL808026

  9. NM_001406050.1 → NP_001392979.1  NHS-like protein 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL807784, AL808026

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    100892942..101135661
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247499.3 → XP_011245801.1  NHS-like protein 2 isoform X2

    Conserved Domains (1) summary
    pfam15273
    Location:646 → 801
    NHS; NHS-like

  2. XM_030251165.2 → XP_030107025.1  NHS-like protein 2 isoform X17

    Conserved Domains (1) summary
    pfam15273
    Location:258 → 413
    NHS; NHS-like

  3. XM_006527718.5 → XP_006527781.1  NHS-like protein 2 isoform X3

    Conserved Domains (1) summary
    pfam15273
    Location:553 → 708
    NHS; NHS-like

  4. XM_006527727.5 → XP_006527790.1  NHS-like protein 2 isoform X14

    Conserved Domains (1) summary
    pfam15273
    Location:371 → 505
    NHS; NHS-like

  5. XM_006527720.5 → XP_006527783.1  NHS-like protein 2 isoform X5

    Conserved Domains (1) summary
    pfam15273
    Location:544 → 699
    NHS; NHS-like

  6. XM_030251164.2 → XP_030107024.1  NHS-like protein 2 isoform X10

    Conserved Domains (1) summary
    pfam15273
    Location:437 → 592
    NHS; NHS-like

  7. XM_036161746.1 → XP_036017639.1  NHS-like protein 2 isoform X15

  8. XM_006527721.5 → XP_006527784.1  NHS-like protein 2 isoform X6

    See identical proteins and their annotated locations for XP_006527784.1

    Conserved Domains (1) summary
    pfam15273
    Location:539 → 694
    NHS; NHS-like

  9. XM_036161747.1 → XP_036017640.1  NHS-like protein 2 isoform X17

    Conserved Domains (1) summary
    pfam15273
    Location:258 → 413
    NHS; NHS-like

  10. XM_030251161.2 → XP_030107021.1  NHS-like protein 2 isoform X1

    Conserved Domains (1) summary
    pfam15273
    Location:658 → 813
    NHS; NHS-like

  11. XM_030251162.2 → XP_030107022.1  NHS-like protein 2 isoform X4

    Conserved Domains (1) summary
    pfam15273
    Location:551 → 706
    NHS; NHS-like

  12. XM_030251163.2 → XP_030107023.1  NHS-like protein 2 isoform X7

    Conserved Domains (1) summary
    pfam15273
    Location:507 → 662
    NHS; NHS-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1AXH1.2 GenPept UniProtKB/Swiss-Prot:B1AXH1

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