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pomcb proopiomelanocortin b [ Danio rerio (zebrafish) ]

Gene ID: 100034412, updated on 12-Sep-2024

Summary

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Official Symbol
pomcbprovided by ZNC
Official Full Name
proopiomelanocortin bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041014-294
See related
Ensembl:ENSDARG00000069307 AllianceGenome:ZFIN:ZDB-GENE-041014-294
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-203k16.2
Summary
Predicted to enable neuropeptide hormone activity. Acts upstream of or within regulation of hematopoietic stem cell differentiation. Predicted to be located in extracellular region. Is expressed in brain and preoptic area. Human ortholog(s) of this gene implicated in familial Mediterranean fever; obesity; and osteoarthritis. Orthologous to human POMC (proopiomelanocortin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See pomcb in Genome Data Viewer
Location:
chromosome: 20
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (42968206..42978336, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (43071576..43081225, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene Pim proto-oncogene, serine/threonine kinase, related 110 Neighboring gene EFR3 homolog Bb (S. cerevisiae) Neighboring gene si:ch211-203k16.3 Neighboring gene sorting nexin 9b Neighboring gene monooxygenase, DBH-like 1, like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish Bioassay for Screening Therapeutic Candidates Based on Melanotrophic Activity. Hong TI, et al. Int J Mol Sci, 2021 Aug 27. PMID 34502223, Free PMC Article
  2. Subfunctionalization of expression and peptide domains following the ancient duplication of the proopiomelanocortin gene in teleost fishes. de Souza FS, et al. Mol Biol Evol, 2005 Dec. PMID 16093565
  3. Identification of two proopiomelanocortin genes in zebrafish (Danio rerio). Gonzalez-Nunez V, et al. Brain Res Mol Brain Res, 2003 Dec 12. PMID 14667571
  4. Enhancer turnover and conserved regulatory function in vertebrate evolution. Domené S, et al. Philos Trans R Soc Lond B Biol Sci, 2013 Dec 19. PMID 24218639, Free PMC Article
  5. Subfunctionalization of POMC paralogues in Senegalese sole (Solea senegalensis). Wunderink YS, et al. Gen Comp Endocrinol, 2012 Feb 1. PMID 22142534

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
  
enables hormone activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of hematopoietic stem cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
proopiomelanocortin b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083051.1 → NP_001076520.1  proopiomelanocortin b precursor

    See identical proteins and their annotated locations for NP_001076520.1

    Status: PROVISIONAL

    Source sequence(s)
    AL845420
    UniProtKB/TrEMBL
    A0A8M1NCD8, Q5SPP4
    Related
    ENSDARP00000091524.2, ENSDART00000100751.3
    Conserved Domains (2) summary
    pfam00976
    Location:166 → 183
    ACTH_domain; Corticotropin ACTH domain
    pfam08035
    Location:184 → 213
    Op_neuropeptide; Opioids neuropeptide

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    42968206..42978336 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005170169.5 → XP_005170226.1  proopiomelanocortin b isoform X1

    See identical proteins and their annotated locations for XP_005170226.1

    UniProtKB/TrEMBL
    A0A8M1NCD8, Q5SPP4
    Conserved Domains (2) summary
    pfam00976
    Location:166 → 183
    ACTH_domain; Corticotropin ACTH domain
    pfam08035
    Location:184 → 213
    Op_neuropeptide; Opioids neuropeptide

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395344.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    116200..120382 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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