prnpb prion protein b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prnpbprovided by ZNC
Official Full Name: prion protein bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041221-2
See related: Ensembl:ENSDARG00000044048 AllianceGenome:ZFIN:ZDB-GENE-041221-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: PrP1; PrP-1; prnprs1; stPrP-1; zgc:123004
Summary: Predicted to enable calcium-dependent phospholipid binding activity and phosphatidylserine binding activity. Acts upstream of or within several processes, including calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; epiboly involved in gastrulation with mouth forming second; and homophilic cell adhesion via plasma membrane adhesion molecules. Located in cell surface and plasma membrane. Is expressed in cranial ganglion; eye; floor plate; and forebrain. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (20628698..20632779)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (20671317..20675398)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that mutations in mouse and zebrafish prion protein (PrP) similarly affect their subcellular localization patterns.
Title: Conserved roles of the prion protein domains on subcellular localization and cell-cell adhesion.
Amyloid beta precursor protein and prion protein have a conserved interaction affecting cell adhesion and central nervous system development.
Title: Amyloid beta precursor protein and prion protein have a conserved interaction affecting cell adhesion and CNS development.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylserine binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adherens junction maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within central nervous system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within epiboly involved in gastrulation with mouth forming second	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within epiboly involved in gastrulation with mouth forming second	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein homooligomerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell-cell adhesion mediated by cadherin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: prion protein b

Names: prion protein 1; prion protein, related sequence 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.