pou6f2 POU class 6 homeobox 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pou6f2provided by ZNC
Official Full Name: POU class 6 homeobox 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-091118-71
See related: Ensembl:ENSDARG00000086362 AllianceGenome:ZFIN:ZDB-GENE-091118-71
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch211-124o16.3
Summary: Enables sequence-specific DNA binding activity. Acts upstream of or within regeneration. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in nephroblastoma. Orthologous to human POU6F2 (POU class 6 homeobox 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (10039163..10273916)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (9914170..10130788)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

mutations in the zinc-binding domain of Apobec2 diminish its ability to stimulate Pou6f2 binding to DNA, and knockdown of Ubc9 or Pou6f2 suppressed retina regeneration
Title: Zinc-binding domain-dependent, deaminase-independent actions of apolipoprotein B mRNA-editing enzyme, catalytic polypeptide 2 (Apobec2), mediate its effect on zebrafish retina regeneration.

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Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

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The following sections contain reference sequences that belong to a specific genome build. Explain

XM_068217160.1 → XP_068073261.1 POU domain, class 6, transcription factor 2 isoform X1
XM_068217161.1 → XP_068073262.1 POU domain, class 6, transcription factor 2 isoform X2

Related

ENSDARP00000120553.2, ENSDART00000144186.4
XM_021470288.2 → XP_021325963.1 POU domain, class 6, transcription factor 2 isoform X1

UniProtKB/TrEMBL

A0A8M9PGB2

Conserved Domains (3) summary

pfam00046
Location:637 → 690

Homeobox; Homeobox domain

cl22952
Location:504 → 613

Pou; Pou domain - N-terminal to homeobox domain

cl27351
Location:238 → 308

E3_binding; e3 binding domain
XM_017353999.3 → XP_017209488.1 POU domain, class 6, transcription factor 2 isoform X2

UniProtKB/TrEMBL

A0A0R4J6S2, A0A8M6YVT8

Conserved Domains (2) summary

pfam00046
Location:612 → 665

Homeobox; Homeobox domain

cl22952
Location:479 → 588

Pou; Pou domain - N-terminal to homeobox domain
XM_068217162.1 → XP_068073263.1 POU domain, class 6, transcription factor 2 isoform X3