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ehhadh enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase [ Danio rerio (zebrafish) ]

Gene ID: 100000859, updated on 5-Oct-2024

Summary

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Official Symbol
ehhadhprovided by ZNC
Official Full Name
enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2581
See related
Ensembl:ENSDARG00000070029 AllianceGenome:ZFIN:ZDB-GENE-040426-2581
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
MFE1; zgc:77526
Summary
Predicted to enable dodecenoyl-CoA delta-isomerase activity; enoyl-CoA hydratase activity; and long-chain-3-hydroxyacyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be active in peroxisome. Is expressed in male organism. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 3. Orthologous to human EHHADH (enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See ehhadh in Genome Data Viewer
Location:
chromosome: 9
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (12428226..12443520, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (12457023..12472317, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene nucleoporin 35 Neighboring gene zgc:162707 Neighboring gene transmembrane protein 41aa Neighboring gene insulin-like growth factor 2 mRNA binding protein 2a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of novel lipid biomarkers in xmrk- and Myc-induced models of hepatocellular carcinoma in zebrafish. Monroe JD, et al. Cancer Metab, 2022 Apr 4. PMID 35379333, Free PMC Article
  2. Zebrafish embryos as a screen for DNA methylation modifications after compound exposure. Bouwmeester MC, et al. Toxicol Appl Pharmacol, 2016 Jan 15. PMID 26712470
  3. Mechanisms of toxicity of di(2-ethylhexyl) phthalate on the reproductive health of male zebrafish. Uren-Webster TM, et al. Aquat Toxicol, 2010 Sep 1. PMID 20561692
  4. Dietary Succinate Impacts the Nutritional Metabolism, Protein Succinylation and Gut Microbiota of Zebrafish. Ding Q, et al. Front Nutr, 2022. PMID 35685883, Free PMC Article
  5. Triclosan (TCS) exposure impairs lipid metabolism in zebrafish embryos. Ho JCH, et al. Aquat Toxicol, 2016 Apr. PMID 26828895

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC77526

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 3-hydroxyacyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-hydroxyacyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3-hydroxyacyl-CoA dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables delta(3)-delta(2)-enoyl-CoA isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables delta(3)-delta(2)-enoyl-CoA isomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables enoyl-CoA hydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables enoyl-CoA hydratase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain-3-hydroxyacyl-CoA dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid beta-oxidation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
peroxisomal bifunctional enzyme
Names
DKEYP-30D5.2
PBE
PBFE
enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase
l-pbe
multifunctional enzyme 1
NP_996951.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207068.1 → NP_996951.1  peroxisomal bifunctional enzyme

    See identical proteins and their annotated locations for NP_996951.1

    Status: PROVISIONAL

    Source sequence(s)
    BC066545
    UniProtKB/Swiss-Prot
    Q6NYL3
    Related
    ENSDARP00000093211.3, ENSDART00000102434.4
    Conserved Domains (4) summary
    cd06558
    Location:11 → 186
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    PRK11154
    Location:11 → 702
    fadJ; multifunctional fatty acid oxidation complex subunit alpha; Reviewed
    pfam00725
    Location:473 → 577
    3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
    pfam02737
    Location:297 → 471
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    12428226..12443520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NYL3.1 GenPept UniProtKB/Swiss-Prot:Q6NYL3

Gene LinkOut

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