Similar studies for GEO DataSets (Select 200023077) - GEO DataSets

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Items: 2

Select item 2000230771.

Mode of action studies of the novel bisquaternary bisnaphthalimide MT02 against Staphylococcus aureus

(Submitter supplied) Screening of various bisquaternary bisnaphthalimides against a variety of human pathogens revealed one compound, designated MT02, with strong inhibitory effects against gram-positive bacteria. The minimal inhibitory concentrations ranged from 0.31 µg/ml against community-acquired methicillin resistant Staphylococcus aureus (MRSA) strain USA300 to 20 µg/ml against Streptococcus pneumonia. DNA-microarray studies generated a transcriptional signature characterized by a strong increase of genes involved in DNA-metabolism, DNA-replication, SOS-response and transport of positively charged compounds. more...

Organism:: Staphylococcus aureus subsp. aureus Mu50; Staphylococcus aureus subsp. aureus MSSA476; Staphylococcus aureus; Staphylococcus aureus subsp. aureus NCTC 8325; Staphylococcus aureus subsp. aureus N315; Staphylococcus aureus subsp. aureus USA300; Staphylococcus aureus subsp. aureus MRSA252; Staphylococcus aureus subsp. aureus COL; Staphylococcus aureus subsp. aureus MW2

Type:: Expression profiling by array

Platform:: GPL7137
2 Samples

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Accession:: GSE23077

ID:: 200023077

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Select item 2000875722.

RNA-Seq based comparison of Staphylococcus aureus strains resistent and sensitive to MT02

(Submitter supplied) A MT02 sensitive and resistant strain of Staphylococcus LAC USA300 JE2 were exposed to MT02. From those cell RNA was extracted and anylsed by RNA-Seq