GSM108473[Accession] - GEO DataSets

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Items: 3

Select item 2000052291.

Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation

(Submitter supplied) Notch signaling promotes commitment of keratinocytes to differentiation and suppresses tumorigenesis. p63, a p53 family member, has been implicated in establishment of the keratinocyte cell fate and/or maintenance of epithelial self-renewal. Here we show that p63 expression is suppressed by Notch1 activation in both mouse and human keratinocytes through a mechanism independent of cell cycle withdrawal and requiring down-modulation of selected interferon-responsive genes, including IRF7 and/or IRF3. more...

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by array

Platforms:: GPL571 GPL339
4 Samples

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Accession:: GSE5229

ID:: 200005229

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000005712.

[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 08, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The GeneChip Human Genome U133A 2.0 Array is a single array representing 14,500 well-characterized human genes that can be used to explore human biology and disease processes. more...