XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain
This family contains transcriptional regulators containing an N-terminal XRE (Xenobiotic Response Element) family helix-turn-helix (HTH) DNA-binding domain and a C-terminal cupin domain. Included in this family is Escherichia coli transcription factor SutR (YdcN) that plays a regulatory role in sulfur utilization; it regulates a set of genes involved in the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. This family belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.
Feature 1: metal binding site [ion binding site], 3 residue positions
Conserved feature residue pattern:H [QE] H
Evidence:
Comment:The four-coordinate metallocenter usually includes three histidines and one glutamate; however, proteins in this subfamily may bind metal via different amino acids
Structure:1Y9Q: Vibrio cholerae HTH_3 family transcriptional regulator cupin domain binds Zn ion - View structure with Cn3D
Jiyao W et al.(2023). "The conserved domain database in 2023.",