1ESQ,1V8A


Conserved Protein Domain Family
THZ_kinase
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cd01170: THZ_kinase 
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4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine and 1-deoxy-D-xylulose-5-phosphate.
Links
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Statistics
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PSSM-Id: 238575
Aligned: 54 rows
Threshold Bit Score: 193.525
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                       
1ESQ_A       22 LTAVRRHsPLVHSITNNVVTNFTANGLLALGASPVMAYAkEEVADMAKiAGALVLNIGTLSk--eSVEAMIIAGKSANeh 99  Bacillus subtilis
O25516        2 LKELRQKrPLVHNITNYVAAQFVANGLLALGASPLMSDAiDEMRDLAKiSDALAINIGTLNd--rAILCAKEAIKHYKal 79  Helicobacter pylori
NP_345225     7 PFPIGSS-SLIHCITNEISCEMLANGILALGCKPVMADDsREVLDFTKqSQALFINLGHLSa--eKEKAIRMAASYANqs 83  Streptococcus pn...
ZP_00062595  11 ILPLQKA-PLVHCITNDITLETVANTILYLGGKPIMSSDtREFSSLFQsTDALLLNMGRLNe--sHEQSLSQASSLADmt 87  Leuconostoc mese...
AAN23980     35 VRRVRETtPLAQSFTNFVTINLVANAQLAAGGTAAMSFLpDDVIETAKiAGANYINVGTLLp--fYKDALPEIAQRLNyl 112 Bifidobacterium ...
Q97RS6        4 LKLLKEKaPLVICITNDVVKNFTANGLVALGASPAMSEFpADLEDLLKyAGGLLINIGTLTd--eNWKLYQAALKIAEky 81  Streptococcus pn...
AAN86938     33 IGKVRVInPLVHCITNRVTTEKVANSLLAFGSSPAMIDNpKEVEEFAKiASCTYFNLGLHTtqveNINLLEKLRKECMkd 112 malaria parasite...
AAO82474     10 IFPLTTA-PLIQCITNEITCESMANALLYIDAKPIMADDpREFPQMFQqTSALVLNLGHLSq--eREQSLLAASDYARqv 86  Enterococcus fae...
Q8CRN9        4 LERLRSEnPLVICYTNDVVKNFTANGLLSLGASPAMSEApEEAEDFTRmASALLINIGTLTr--eNEEDIIKIGKIANqq 81  Staphylococcus e...
YP_046656    15 WEKLQEQaPLVQCITNSVAANYAANVLLAAGASPAMIDNpFEARSFTEiSGALSINVGTPTt--eQIQAMQISAKTAHeh 92  Acinetobacter sp...

Feature 1             #                           # #  #                                        
1ESQ_A      100 GVPVILDPVGAGat-pFRTESARDIIrevrlAAIRGNAAEIAHTVgvtdwlikgvdageg-------------------- 158 Bacillus subtilis
O25516       80 NKPIVLDPVGCSas-aLRHDTSLELLksggiSALRGNAAELGSLVgisceskgldsnda--------------------- 137 Helicobacter pylori
NP_345225    84 SLPMVVDAVGVTts-sIRKSLVKDLLdy-rpTVLKGNMSEIRSLVglkhhgvgvdasakdq------------------- 142 Streptococcus pn...
ZP_00062595  88 KKPTVVDLVGYGit-nERTKLGMAMArn-hpTVIKGNTSEIRRFVglpslakgidgassdqhd----------------- 148 Leuconostoc mese...
AAN23980    113 DKPWVLDPVAAGig-rTRTAILQAFKaa-ppTMIRANASEVIALAnmwglntetvgdasehrpagvesvddvesatgaav 190 Bifidobacterium ...
Q97RS6       82 NVPAVLDPVACGag-eYRKKVADDLInnyklAAIRGNAGEIASLVgidvaskgvdsagv--------------------- 139 Streptococcus pn...
AAN86938    113 KFMLIIDPIAVGat-tYRTNVIKDIIlkcqpNVIKGNIAEIYYLDkgeflgkgvdsnnnnt------------------- 172 malaria parasite...
AAO82474     87 NKLTVVDLVGYGas-dIRNEVGEKLVhn-qpTVVKGNLSEMRTFCqlvshgrgvdgspldqse----------------- 147 Enterococcus fae...
Q8CRN9       82 GTPIVFDPVAVGas-tYRKNFCQRFLgevnvTVIKGNASEILTLIdfnttmkgtdsdse--------------------- 139 Staphylococcus e...
YP_046656    93 DIPWVLDPVGYGpilkWRSDMVDELLqy-hpSVIRGNASEIGALAgslvqskgvdstlk--------------------- 150 Acinetobacter sp...

Feature 1                                 # # #                   #     # #                     
1ESQ_A      159 -----ggdiirlaqqaaqkLNTVIAITGEVDVIADTSHVYTLHNG--HKLLTKVTGAGSLLTSVVGAFCAVeen-plfAA 230 Bacillus subtilis
O25516      138 ------atpveiiklaaqkYSVIAVMTGKTDYVSDGKKVLSITGG--SEYLALITGAGCLHAAACASFLSLkkd-pldSM 208 Helicobacter pylori
NP_345225   143 ---etedllqvlkdwcqtyPGMSFLVTGPKDLVVSKNQVAVLGNG--CTELDWITGTGDLVGALTAVFLSQgkt-gfeAS 216 Streptococcus pn...
ZP_00062595 149 --qalkdlilslkqitteyADTVFVATGKKDVIVQNDKHLILSNG--VDELDKFVGTGDMVGAIITTLLAVged-pwvAS 223 Leuconostoc mese...
AAN23980    191 alaqylteqhakhsshdasTRCAVAVSGIADLVTDGETVYRLPGG--SAMMTKIIGAGCSLGGVAATYLAVsdp--ltAA 266 Bifidobacterium ...
Q97RS6      140 ------dnideialaanekFNIPIVVTGEVDAIAVNGEVVMIHNG--SAMMPKVIGTGCLLGAVVASFIGLekgqelkSL 211 Streptococcus pn...
AAN86938    173 ---hnetdvinsarnvalkYNCAVVVTSKTDYIVSPCSHYVAKINcdLKILTKITGSGCSVSALCAAATSVypqnpfiAC 249 malaria parasite...
AAO82474    148 --eaieeliqalrqqtqkfPQTVFLATGIQDVLVSQEQVIVLQNG--VPELDCFTGTGDLVGALVAALLGEgna-pmtAA 222 Enterococcus fae...
Q8CRN9      140 ------ldsvniakkaantLNTAIVITGKDDIIAKNEKIIKLSNG--SPLLTKITGAGCLLGGVLASFLFRntqpsidLL 211 Staphylococcus e...
YP_046656   151 ------sdemfqlahnlltKTSCVAISGETDYILSNAMTCIVKVRggSHLQPKITATGCALGTLIAAYCAVapv--hlAT 222 Acinetobacter sp...

Feature 1                                            
1ESQ_A      231 IAAISSYGVAAQLAAQQTadk--gpGSFQIELLNKLS 265 Bacillus subtilis
O25516      209 AQLCALYKQAAFNAQKKVlenngsnGSFLFYFLDALS 245 Helicobacter pylori
NP_345225   217 CLAVSYLNIAAEKIVVQGmg----lEEFRYQVLNQLS 249 Streptococcus pneumoniae TIGR4
ZP_00062595 224 QFAISYLNVAAEKALSLTng----mENFRREVLNQID 256 Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293
AAN23980    267 LSASLLYNRAGEVADTTShg----pGSFQVAFLDALW 299 Bifidobacterium longum NCC2705
Q97RS6      212 KTAVLVYNIAGEIAEKRPngh--lpGTFKVEFINALY 246 Streptococcus pneumoniae
AAN86938    250 ISATLIYKLAAFKAYQKEky----pGSLSHKIIDDIY 282 malaria parasite P. falciparum
AAO82474    223 VAAVSYFNLCGEKAKTKSqg----lADFRQNTLNQLS 255 Enterococcus faecalis V583
Q8CRN9      212 VEAVSVYNIAAEFAEQAPhvn--gpSTFLSELLDQLY 246 Staphylococcus epidermidis
YP_046656   223 IAAHIHFAIAGKLAYDQAqt----iGSFNTMFMDYIH 255 Acinetobacter sp. ADP1

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