Conserved Protein Domain Family
hemA

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PRK00045: hemA 
glutamyl-tRNA reductase; Reviewed
Statistics
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PSSM-Id: 234592
Aligned: 618 rows
Threshold Bit Score: 267.049
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
290958357   1 MSLLVVGLSHRSAPVSVLERAALSLDAQIKLLQDTVAAEPAAEAALLATCNRIELYADvDKFHAg-vA-ELS-TLLA--R 75 
15790694    4 NTGVVSGVRVSHETASLDELAAASAASTEAALDALLEQPPVEEAFVLQTCHRVEAYVV--TADQasgR-----RALGgaG 76 
169236435   4 NTGVVSGVRVSHETASLDELAAASAASTEAALDALLEQPPVEEAFVLQTCHRVEAYVV---------TaDQA-SGRR--A 71 
222480542   5 GAITGISVAYSRATVDEIEAAGG--DGVRATVSDLLARDGVEEAFAIQTCNRSEAYVV--T-D-------RTiDGSV--A 70 
289580897   5 GVVTAGRVTHESGTVDDLAAASP--DSQQAAVAELCSASGIDEAYVLSTCNRVEAYVVaS---------DPV-IGRT--A 70 
76802884    6 GIVVGASVSHSHASIDQIETA--ADGSQQTAVEELLSKEGVSEAFVLQTCNRAEAYVVaNDSETg-tA-ALA-GYLA--- 77 
284166504   5 GVVTAARVTHESGSVDDLADA--SPESQRDAVADLCSVPEIEEAYVLSTCNRVEAYVV--GTDAs-vGrAALeEFFAavD 79 
110669214   4 GVICGVRVSHNRASVEEIELA--GERDSRTIMETLLTRDGITESFAIQTCNRSEAYVVaDGAVAg-rR-----------A 69 
292656439   3 DSGVISGVSVAHDRASVREIEAASSDDVQTVVERLLARDGVSEAFSLQTCNRAEAYVVtDDATDg-rR-----------A 70 
257053886   5 GYITAASVAHQHGSVEDIDAAAA--DSQLAGVEQLLEAPHVTEAFVLQTCNRAERYVVsDDPEAg-rA-----------A 70 
290958357  76 HSGVGLDE-ITPYLYVHYEDRAVHHLFSVACGLDSMVVGEGQILGQIKDSLARAQELHTAGRLLNDLFQQSLRVGKRAHS 154
15790694   77 FNPAGGGA------ISMGHEDSLRHLLRVAAGLESLVVGEDQILGQLRDAYDAAKDAGGIDHVLREAVTKAMHVGERART 150
169236435  72 LGGAGFNP-AGGGAISMGHEDSLRHLLRVAAGLESLVVGEDQILGQLRDAYDAAKDAGGIDHVLREAVTKAMHVGERART 150
222480542  71 LESFAPEVrG-GAVRRLDHEESLEHLMRVASGLESLVLGEDQIIGQLREAYEESKSAGGIGPVLKDGVTKALHVGERARN 149
289580897  71 LSEFFAAVdDQDPLVITDHDDSLTHLLRVATGLESVVLGEDQIIGQVRTAYEDARAAGGIGTMLEPAVTKAIHVGERART 150
76802884   78 --GVDDDA-----IRMLSHNQSLKHLMAVACGLESLVIGEDQILGQVRDAYEDARGVGGVGPTLNDAVLKALHVGERART 150
284166504  80 DDAVVVSD----------HDGSLHHLLSVAAGLESVVLGEDQILGQVRTAYEDARTIGGIGEMLETAVTKAIHVGERART 149
110669214  70 LASFAPDV-RDGAVVDMSHEESLRHLLRVATGLESLVLGEDQILGQFKRAIEVARGIGALGPMLEAGVTKAIHVGERARS 148
292656439  71 LDDFAPDV-RDGSVRHMDHEETLRHLMRVASGLESLVLGEDQILGQVKAGIEAAREQDAIGPMLEDALMKAVHVGERARD 149
257053886  71 LQAAMPDE-VDSTVRTLGHEESLRHLLRVAAGLESLVPGEDQILGQVRDAYEDARHVDGLGPVLEEAVTKAIHVGERART 149
290958357 155 ETGIDRAGQSLVTFGLEQFTAGAdvtSW--ARGKRAVVIGAGSMSSLAAATL-ARAGVGEIVIANRTYDRAERLARILte 231
15790694  151 ETAINEGATSLGTAAVRLAERKT----Q--LADARAVVVGAGEMGALAAKAF-ASATVAEIVIANRTPARAVRVADMVsv 223
169236435 151 ETAINEGATSLGTAAVRLAERKT----Q--LADARAVVVGAGEMGALAAKAF-ASATVAEIVIANRTPARAVRVADMVsv 223
222480542 150 ETSINEGVVSLGSAAVRLAADEId------LTDGSAVVVGAGEMGTLAARTL-DDTPVSEIVVANRTVPNAAFVAEEVet 222
289580897 151 ETKINEGIVSLGSAATQLAGQTV---S---LEGATALVVGAGEMGQLAARSL-ADAGVDELVVSNRTVSRAEHLISDVdh 223
76802884  151 ETAINEGAVSLGSAAVRFAAERH---G---VTGSTALVVGAGEMATLAAKAL--DDPASRVIVANRTRERAERLAEELst 222
284166504 150 ETEINEGVVSLGSAATKLAGREI----D--IDGTTALVVGAGEMSRLAARSL-ADTGVDEVVVANRTVAHAEHLAAELdv 222
110669214 149 ETSINEGAVSIGSAAVRLAGQSV---G---LNGRKALVIGAGEMGSLVAESL-ASTNISEVVIANRTIENAESIAETIns 221
292656439 150 ETAINEGAVSLGSAAVRLARGEL----DapIGEVEALVVGAGEMGTLATKAL-ASVDVGDLVVANRTVANARHLAREVpg 224
257053886 150 ETAINEGVVSLGSAAVELAERER----D--LEAATALVIGAGEIGTLAAKAVdARSDVAHLYVANRTVPHAEHVTSIVdv 223
290958357 232 qgetdvlaRAVPMESVPGELTRADIAVSCTGATGLVL------TAG--MVAAAVEGRVpegapsrpaarpeirtgiravl 303
15790694  224 p------aeATTLADARGRLDAADVVVTATGSPEHVLpasafaDAG---------------------------------- 263
169236435 224 p------aeATTLADARGRLDAADVVVTATGSPEHVL------PAS--AFAD---------------------------- 261
222480542 223 ------paEAVPLADLATVIPDADLVIAATGSPDPVI------RSE--HVTGADR------------------------- 263
289580897 224 d-----dtRAVPLESLDTLAARADVIVAATGSDEPVV------CRR--HFVGTDSEDAmvged----------------- 273
76802884  223 t------asVVGVDSVDEAADAADVVVSATGSEDYVIdtadlgGVG---------------------------------- 262
284166504 223 d------aeAVPLEALSAVAGDADVVVTATGSEEPIL------EPDhlATDGGADAEA---------------------- 268
110669214 222 p------ayAVSLDSLTEVITEASIIMTATGYGKYLI------EPT--DIDG---------------------------- 259
292656439 225 v------skAVGLGDLGGRLRDADLVITATSSPDYVV------TPN--QLDD---------------------------- 262
257053886 224 a------asAIGLDDVASVVDRADLVVSATGSADPIV------EPA--AFET---------------------------- 261
290958357 304 pptsvgsdddcpldlpavqgggfsvhgedavagmdaatleqhaawvdnatvdrrasrrtpereaprtpaadaelitalva 383
15790694      --------------------------------------------------------------------------------    
169236435     --------------------------------------------------------------------------------    
222480542     --------------------------------------------------------------------------------    
289580897     --------------------------------------------------------------------------------    
76802884      --------------------------------------------------------------------------------    
284166504     --------------------------------------------------------------------------------    
110669214     --------------------------------------------------------------------------------    
292656439     --------------------------------------------------------------------------------    
257053886     --------------------------------------------------------------------------------    
290958357 384 avavsgritelrrpeavvevprpAPVLALLDLAMPRDIDAAAHRLAGVRLVDIESLAEVSADAp--MAADVDLVRRIVSD 461
15790694  264 -------------------------DTVVVDLAQPRDVAPGAGGHDGVAVHDLDDLEAVTAATrerREDAAREVEAMIET 318
169236435 262 -----------------------AGDTVVVDLAQPRDVAPGAGGHDGVAVHDLDDLEAVTAATrerREDAAREVEAMIET 318
222480542 264 --------------------------LVCIDIAQPRDIEPALADRDKVTLYDIDALEDVTRKTresREEEAREVEAIIDE 317
289580897 274 -------------------atvsSSERVVVDLGQPRDVDPTIDALDAITVYDLDDLETITEETrkqRADAAREVEAMIDR 334
76802884  263 -------------------------ETCVLDIAQPRDVAPGADGIDGVAVYDLDTIESVTDEArakRREAAETVETMIDE 317
284166504 269 -----------------------GTDRVVVDLGQPRDVEPAAGELSTVAVYDLDDLESITEETreqRADAASEVESMVDR 325
110669214 260 -----------------------AGETFIIDLAQPRNVHPATADIENAIVQDIDALESITKETeasRQAAAREVDAMIDE 316
292656439 263 -----------------------AGETMLIDIAQPRDVDPDASDLAGVRVHDIDDLETVTDRTaerRERAASEVEAMIDE 319
257053886 262 -----------------------TGDTVVIDIGQPRDIPPIVDEQPGTDVFDLDDLEAVTAETranREAAAARVEDIVED 318
290958357 462 EVAAFGAAQRAAHITPTVVALRAMAADVVASEIARLEGRL------PGl----dD----KHRGEITQTVRRVVDKLLHAP 527
15790694  319 EFERLLTQYKRKRADEVIARMYESADRLKSREVQTAVHRL------EAesgslsA----DEREVVESMADALVSQLLAAP 388
169236435 319 EFERLLTQYKRKRADEVIARMYESADRLKSREVQTAVHRL------EAesgslsA----DEREVVESMADALVSQLLAAP 388
222480542 318 ELDRILEAYKRKRADNAISAMYAGADRVKAREVDRAVSKL------EAq-----GgltdEQRETVEDLADALVGQLLAAP 386
289580897 335 EFDLLCDQYKRARADEVIGAMYESAAQIKQRELETALSQL------EGes---fTp---AQREVVEAMADALVNQLLAPP 402
76802884  318 EFEHLMTQYKRKRADQVIAAMYEGAERIKARELRTAVSKFeae--------redGls-eREHEIVESMADALVGQLLSAP 388
284166504 326 EFDLLCDQYKRARADQVIAAMYESAERMKERELETALSRL------EGee--ftA----EQREVVEAMADALVNQLLAPP 393
110669214 317 EFDRLLESYKRQRADEAISEMYEAAEHVKRREVETALEKLekqgtlTD-----------NQRETISSMADTLINQLLAAP 385
292656439 320 EFDRLLAAYKRKRADEAISSMYEAAEHVKRREVSTALSKL------ESqgd-----ltdEQRETVESLADALVGQILAAP 388
257053886 319 ELAHLLTRYKRTRADDVISTMYESAERVKAREVEQALGSL-------Dld--------dEEREVVEAMADSLVNQLLAAP 383
290958357 528 TVRVKQlAAEPGGAGYADALRTLFD---------------------L--------Dqe---------------------- 556
15790694  389 TKSLRD-AAAEDDWSTIATALELFNpe----------------------------------------------------- 414
169236435 389 TKSLRD-AAAEDDWSTIATALELFNp-------------------eF--------Edgmpfdas---------------- 424
222480542 387 TRSLRD-AAGEDDWETIRTALRLFDpefdtlpegpgasgsghdaapgdievppgsvaeeldd------------------ 447
289580897 403 TRSLRE-AAAEDDWSTINTALQLFDp-------------------dF--------Gdedgpsllertqtaqrteaafeat 454
76802884  389 TQSLRD-AAEEDDWATINAALQLFGpg----------------------------------------------------- 414
284166504 394 TKSLRE-AAAEDDWSTINTALQLFDpd------------------fA--------Gdd---------------------- 424
110669214 386 TKSLRD-AAAEDDWTTIQTAMTLFD---------------------P--------Nfggdtpqpdrpddipraaergdis 435
292656439 389 TKSLRD-AAGDDDWTTIQTAMQLFNpdf----------------gdL--------Gasesagpsgpsiefsgeppedldr 443
257053886 384 TKSLRD-AAEADDWATIDTALALFDpdfgetefppsvadvdadvpdRfsrlvdadD------------------------ 438
290958357 557 ---------------tvA 559
15790694  415 ---------------feD 417
169236435 425 ---------rggdaasaE 433
222480542     ------------------    
289580897 455 ddd--------------- 457
76802884  415 ---------------leP 417
284166504 425 ---------------gpV 427
110669214 436 gddlpddvpnhiaekvsD 453
292656439 444 ealegevprrvleqlsdD 461
257053886     ------------------    
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