2WJV,5MZN,5EAN,5WWP,4B3G,2XZL,2XZO,2GJK,5EAX,5EAW,4B3F


Conserved Protein Domain Family
DEXXQc_Upf1-like
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cd17934: DEXXQc_Upf1-like (this model, PSSM-Id:350692 is obsolete and has been replaced by 438708)
Click on image for an interactive view with Cn3D
DEXXQ-box helicase domain of Upf1-like helicase
The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They belong to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Links
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Statistics
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PSSM-Id: 350692
Aligned: 61 rows
Threshold Bit Score: 68.0325
Created: 21-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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ATP bindingDEAD box
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:2GJK: Human Upf1 helicase binds Mg.AMP-PNP, contacts at 4A
    - View structure with Cn3D
  • Structure:5MZN: Saccharomyces cerevisiae helicase Sen1 binds Mg.ADP, contacts at 4A
    - View structure with Cn3D
  • Comment:Walker A motif or motif I
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #                    ######                                                    
2WJV_A       360 SQVYAVKTVLQr-pLSLIQGPPGTGKTVTSATIVYhlarqgngpVLVCAPSNiAVDQLtekihqtglkvvrlcaksreai 438  human
2GJK_A       184 SQVYAVKTVLQr-pLSLIQGPPGTGKTVTSATIVYhlarqgngpVLVCAPSNiAVDQLtekihqtglkvvrlcaksreai 262  human
EGC77370     349 KQLLAIHNAMKn-pVSYIQGPPGTGKTSTIVNTILtaff-ndktVLFTSYNNkPIDGVaeklskitydnypplfpmleik 426  Treponema dent...
CBK92482     330 DQLLAINNAMKy-pLAYIQGPPGTGKTNTIINTIVtaff-nnvtVLFASYNNvPIDNVfeklssmkyrgktipfpvlrlg 407  Eubacterium re...
ZP_07030085  333 SQALAVQDVRRg-gNLVIQGPPGTGKSQTIANIIAsava-dgktVLFVAEKMaALDVVkrrldqagvgdaclelhsnkan 410  Acidobacterium...
CBL40235     182 SQYKAVKNAMEn-qISVIQGPPGTGKTQTILNIIAnilm-qgktVQIVSNNNsATENVyeklsspkynlgfiaatlgssk 259  butyrate-produ...
AAL95638     128 SQYKAVRNAMEk-qISIIQGPPGTGKTQTILNIIAnilm-qgktVQIVSNNNsATENVyeklsstkynlgfiaatlgssk 205  Fusobacterium ...
CBK68615     186 SQQKAVQAAFEn-qISVVQGPPGTGKTQTILNIIAnilv-rgktVQVVSNNNsAIVNVleklskydmgfivallgstank 263  Bacteroides xy...
AEC46004      34 KQEHSVKKAIAsrdVFYLQGPPGTGKTQTICAMAEefik-rgenILITSSTHeAIENFmnrlnennlnnpnyiifkfdyn 112  Mycoplasma hyo...
ADD91734     181 SQLLAVERAFSs-qISVIEGPPGTGKTQTILNIVAnili-qnktVAILSNNNsAVSNVyekmdkqqlgyvvarlgstenr 258  Escherichia coli

Feature 1                                                                                        
2WJV_A       439 dspvsflalhnqirnmdsmpelqklqql---------------------------------------------------- 466  human
2GJK_A       263 dspvsflalhnqirnmdsmpelqklqql---------------------------------------------------- 290  human
EGC77370     427 nndkipqalkkvrslyetaknkivfkdmlikkkrleldktekinrlleeyekrveidetkivldkmtdkiktmefnlflq 506  Treponema dent...
CBK92482     408 ntekvmeaikyinelrtqvqslqifastldkrkddridrakrlsarlkeyeeildlkerketlthlmkyqehmkntmkll 487  Eubacterium re...
ZP_07030085  411 krelleelrrtwelgsplgtiddaldssftsardqlnsyvnllhqplvpsgftayqvigeivrlrhagqtpvefrlldap 490  Acidobacterium...
CBL40235     260 nkklfvehqdaaypdfsswktgedqsvlqkeieeqssqlksvfdkqeklaclrqelsqlvteqeyfnqyvkesdvhtdsi 339  butyrate-produ...
AAL95638     206 nkknfiehqdtnypdfsswkieenpndlqkkiaeqsnqlkivfdkqeklaclrqelsqlltekeyfnqyieklkisieni 285  Fusobacterium ...
CBK68615     264 ekfietqeeekqypehfeswhdvdadqpqfldqihhqteelksifskqerlamarqeiqalkiewqhylqefgtkeftlq 343  Bacteroides xy...
AEC46004     113 skrnndfqtskiypnfiskiehwlenpqeensvlqekileieawivktnlnveeyfgfsayldtlieriekntvfefeke 192  Mycoplasma hyo...
ADD91734     259 qqffstsisrseevlpdspsanaiddvlqqvkkhlnainqvaslkaeinelnieykylqqwqsqnlrpeelfshkyrfss 338  Escherichia coli

Feature 1                                                                                        
2WJV_A           --------------------------------------------------------------------------------      human
2GJK_A           --------------------------------------------------------------------------------      human
EGC77370     507 gies---------------------------------------------------------------------------- 510  Treponema dent...
CBK92482     488 pfqtdlqg------------------------------------------------------------------------ 495  Eubacterium re...
ZP_07030085  491 twdpqqrreraelleelsqriavigvpaqhvwrgigieqilphdverltarlvklrenlsglldrytefaptllmevpqs 570  Acidobacterium...
CBL40235     340 kfkkklsskqwmvlwqecqliseekt------------------------------------------------------ 365  butyrate-produ...
AAL95638     286 kfkkklsskhwinlwqecqsilenkk------------------------------------------------------ 311  Fusobacterium ...
CBK68615     344 qrknsssadllnlwnecqqfaekeqssslrgia----------------------------------------------- 376  Bacteroides xy...
AEC46004     193 hlikedfdinninsintcyie----------------------------------------------------------- 213  Mycoplasma hyo...
ADD91734     339 qkttdlmayihylsdrrigfr----------------------------------------------------------- 359  Escherichia coli

Feature 1                                                                                        
2WJV_A           --------------------------------------------------------------------------------      human
2GJK_A           --------------------------------------------------------------------------------      human
EGC77370         --------------------------------------------------------------------------------      Treponema dent...
CBK92482         --------------------------------------------------------------------------------      Eubacterium re...
ZP_07030085  571 lhgmisveetansiatspavdaaarllsaqtdetpkpswlstfftqkselqqsvttlsqllklsveesarkslqqlvama 650  Acidobacterium...
CBL40235         --------------------------------------------------------------------------------      butyrate-produ...
AAL95638         --------------------------------------------------------------------------------      Fusobacterium ...
CBK68615         --------------------------------------------------------------------------------      Bacteroides xy...
AEC46004         --------------------------------------------------------------------------------      Mycoplasma hyo...
ADD91734         --------------------------------------------------------------------------------      Escherichia coli

Feature 1                                                                                        
2WJV_A           --------------------------------------------------------------------------------      human
2GJK_A           --------------------------------------------------------------------------------      human
EGC77370         --------------------------------------------------------------------------------      Treponema dent...
CBK92482         --------------------------------------------------------------------------------      Eubacterium re...
ZP_07030085  651 thaaslpayaaslanpawdngteraarlataastlegaraaigsqlseavwsadlnnarqvlasqgsslfrflngqwraa 730  Acidobacterium...
CBL40235         --------------------------------------------------------------------------------      butyrate-produ...
AAL95638         --------------------------------------------------------------------------------      Fusobacterium ...
CBK68615         --------------------------------------------------------------------------------      Bacteroides xy...
AEC46004         --------------------------------------------------------------------------------      Mycoplasma hyo...
ADD91734         --------------------------------------------------------------------------------      Escherichia coli

Feature 1                                                                                        
2WJV_A           --------------------------------------------------------------------------------      human
2GJK_A           --------------------------------------------------------------------------------      human
EGC77370         --------------------------------------------------------------------------------      Treponema dent...
CBK92482         --------------------------------------------------------------------------------      Eubacterium re...
ZP_07030085  731 nrlvqsylttgkspleevlrlldalskgqaartvlqqedtfgresfgaawrgtdtpakplhalvdwmhsiaplasedreh 810  Acidobacterium...
CBL40235         --------------------------------------------------------------------------------      butyrate-produ...
AAL95638         --------------------------------------------------------------------------------      Fusobacterium ...
CBK68615         --------------------------------------------------------------------------------      Bacteroides xy...
AEC46004         --------------------------------------------------------------------------------      Mycoplasma hyo...
ADD91734         --------------------------------------------------------------------------------      Escherichia coli

Feature 1                                                                                        
2WJV_A           --------------------------------------------------------------------------------      human
2GJK_A           --------------------------------------------------------------------------------      human
EGC77370         --------------------------------------------------------------------------------      Treponema dent...
CBK92482         --------------------------------------------------------------------------------      Eubacterium re...
ZP_07030085  811 lrslaatlnppeslqgplqellrkaaemqrlplhliepfaaqrvlltteleqtcqelkldlteafgvttlpelaldilve 890  Acidobacterium...
CBL40235         --------------------------------------------------------------------------------      butyrate-produ...
AAL95638         --------------------------------------------------------------------------------      Fusobacterium ...
CBK68615         --------------------------------------------------------------------------------      Bacteroides xy...
AEC46004         --------------------------------------------------------------------------------      Mycoplasma hyo...
ADD91734         --------------------------------------------------------------------------------      Escherichia coli

Feature 1                                                                                        
2WJV_A           --------------------------------------------------------------------------------      human
2GJK_A           --------------------------------------------------------------------------------      human
EGC77370     511 -----------------------------------------------------------------knlkkrednlgkidy 525  Treponema dent...
CBK92482     496 -------------------------------------------------------------yqmqkldkriaaigeisda 514  Eubacterium re...
ZP_07030085  891 rlalwaarseqlsnwiayrsrserartlglgdlvsrayngalipaqivpvfemayfeallssmaqehpelgrfdghlhtr 970  Acidobacterium...
CBL40235     366 ------------------------------------------aigfwfkikalfkyrvtdwsiykqdiskiittfqamyy 403  butyrate-produ...
AAL95638     312 ------------------------------------------vigfwfkikaffkygvtdwniykqknlniiitlqniyy 349  Fusobacterium ...
CBK68615     377 ------------------------------------afiqrlkwfffkfrsktickipdkgfykremsliiadfqilfyq 420  Bacteroides xy...
AEC46004     214 -----------------------------------------------thknkvknnqvlnlidalfklaqdnninvwgvk 246  Mycoplasma hyo...
ADD91734     360 -----------------------------------------------nridlllnfrilkvkplmiperrlalftslqls 392  Escherichia coli

Feature 1                                                                                        
2WJV_A       467 ----------------------------------------kdetgelssadekryralkrtaerellmnadvicctcvga 506  human
2GJK_A       291 ----------------------------------------kdetgelssadekryralkrtaerellmnadvicctcvga 330  human
EGC77370     526 ketislinenkrdffmyiyfktvdllkkidlseykdfkdilymekeeeqkkafnqylrndeniykllnifpvmlvtcisa 605  Treponema dent...
CBK92482     515 damqlldrnedefyqylfytsaryikaleepkfqelrqildsdetpeklvnefnkymrksenvrklqrvfpiiittcisa 594  Eubacterium re...
ZP_07030085  971 lvesftaidkqriqsaalqvarihhrripqgsggvgplgvlrgemarrrghmpirklmqnagpavqalkpvmmmsplsva 1050 Acidobacterium...
CBL40235     404 rakraelsgkiadiekylnsvnknlledlcdqsmvvlkdklarkyegnssrktfsednlwkepydvlaeypvilsttfss 483  butyrate-produ...
AAL95638     350 rvkqeellsdiadtekyldgvnknlledlcnqsmiilkdklarrykknnvrkvftkedlwkdpysvlaeypvilsttfss 429  Fusobacterium ...
CBK68615     421 tkyaeleveidtlekelankdaaemarqmadtsmkflknqlfhtygnnhdkpiftlpdlknnwrevqkeypiilsttfss 500  Bacteroides xy...
AEC46004     247 nfkelknkilnkdstknasflkdlyktynentneqnnylesdfnkfvfeynlinvigittttstkinfsdkngvgvadve 326  Mycoplasma hyo...
ADD91734     393 yyektirekqislneyeevfkksdfkillgrltswsmlylkqhlrrnvstrssfsaetyrdefdrfikrfpvigssthsv 472  Escherichia coli

Feature 1                                                    #                                   
2WJV_A       507 gdprlakmqfRSILIDESTQatepecmvpvvlgaKQLILVGDHCQLGpvvmckkaakagls------------------- 567  human
2GJK_A       331 gdprlakmqfRSILIDESTQatepecmvpvvlgaKQLILVGDHCQLGpvvmckkaakagls------------------- 391  human
EGC77370     606 rkvgspkqyfDLTIMDEASQcdnatal-ipiirsNKLMLVGDPQQLNpvivldktdderlkkeynipd------------ 672  Treponema dent...
CBK92482     595 hkigepeplfDMTIMDEASQcnvaisl-vpiirgEKLMLVGDPQQLNpvillgeltnkklrrryhvsd------------ 661  Eubacterium re...
ZP_07030085 1051 qflspgemtfDLLVMDEASQiqpvdal-gaiarcRQVVVVGDERQLPptkffakvtgdasdddddt-------------- 1115 Acidobacterium...
CBL40235     484 rnslnsdvvyDYLIMDEASQvdiatga-lalscaRNVVIVGDTKQLPnvvtgdikakakvifdsfnvs------------ 550  butyrate-produ...
AAL95638     430 rnslnsdvvyDYLIMDEASQvdiatga-lalssaRNAVIVGDTKQLPnivtndiknkakgifdtfnms------------ 496  Fusobacterium ...
CBK68615     501 lsslqrdavyDYIIMDEASQvsvetga-lalscaKNAIIVGDTMQLPnvvteenketlnfianaclikp----------- 568  Bacteroides xy...
AEC46004     327 pkdlfteypiGVVIIDEISKsstpeif-ariilaEKVIFSGDYNQLPpssefepniidqiydglpeqpiqtysqsnqydd 405  Mycoplasma hyo...
ADD91734     473 insigkgallDYVIIDEASQqdivpgi-lglgcaRNVIVVGDRKQLPhvpvllpnspsppaeyync-------------- 537  Escherichia coli

Feature 1                                                               ##
2WJV_A       568 -----------------------------------qslferlvvlgirPIRLQVQYR 589  human
2GJK_A       392 -----------------------------------qslferlvvlgirPIRLQVQYR 413  human
EGC77370     673 ---------------------------vydfmnnsvyktfiandfisnEILLNYHYR 702  Treponema denticola F0402
CBK92482     662 ---------------------------eydyrensiyktylacdavsdEVLLRNHYR 691  Eubacterium rectale M104/1
ZP_07030085 1116 -----------------------------aqvsdiesvlglfsarglpQRMLRWHYR 1143 Acidobacterium sp. MP5ACTX8
CBL40235     551 ---------------------------egyqytnsflqsildvmpnvtQTLLREHYR 580  butyrate-producing bacterium SS3/4
AAL95638     497 ---------------------------egyqytksflqsildvipnvtQVLLREHYR 526  Fusobacterium nucleatum subsp. nuclea...
CBK68615     569 ---------------------------eydcanmsflqsvckvipnvpQTLLREHYR 598  Bacteroides xylanisolvens XB1A
AEC46004     406 eeeedeesslikdpdkkkfrekidqlyknsffktqanqlknlnfnnstYEFLKTSHR 462  Mycoplasma hyorhinis MCLD
ADD91734     538 ------------------------------ekyslldsvcmlfrnmvpVTLLKEHYR 564  Escherichia coli

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