Conserved Protein Domain Family
HemL

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COG0001: HemL 
Glutamate-1-semialdehyde aminotransferase [Coenzyme transport and metabolism]
Glutamate-1-semialdehyde aminotransferase is part of the Pathway/BioSystem: Heme biosynthesis
Statistics
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PSSM-Id: 439772
Aligned: 713 rows
Threshold Bit Score: 317.371
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_015884493   3 AASTMDEVFDRARAAIPGGVSSPV-RAFGsvGGTPRFIASASGPHVTDVDGREYVDLVGSWGPAILGHAHPEVVAAVQEA 81 
WP_004214371  14 RTPTSERAYEELYEHVPAGVASTY-RAF---EPYPMVIDRADGPYLHDVDGNRYIDYDLNNGAGMVGHNHPAVTDALRDQ 89 
WP_012825225  26 LHPTSARLAEEARQHYLYGVPMHWmN--DwgTPTPLFVREARGAHFTCADNIDYTDFCLGDTGAMFGHSPEPVARALEEQ 103
WP_114562996  25 ARPQSARLAEQTEQHYLFGVPLHWmA--DwgTPVPLFVERAQGAHFTDVDGHEYADFCLGDTGAMFGHSPSPVAQRLATA 102
WP_004267647  26 QTPGSAALAEDLGELVPAGVCSTY-RAY---DPYPVHAERATGTTIHDVDGNEYLDFALNNGTQLVGHTHPTLSEATKEQ 101
WP_020458592  39 RTPASEAMHTRALRTMTGGVPSSY-QLR---DPWPIYLTHGRGSLVWDVDGNEYSDFHNGYGSMVQGHAHPAIVRAVTER 114
BAJ50901      21 ATKRSKALYEEALGLTPHGVHSNW-RIF---DPYPLYMSRGKGSRIWDVDGNMYLDFNMAFGALGVGHAHPILVEEMRKV 96 
BAV83475      22 RTKGSGDMYNRARNSLSGGVASSY-QLR---EPWPIYLERGQGPKVWDVDGNEMWDFHNGFGSMLQGHAHPVIGEAIQER 97 
YP_885070     32 RQPRSAEFIARARAHLAGGATSNW-QIA---QPQAVWMSHGYGSKVYDVDGTEYVDMHGGYGAAIAGHGHPAIVAAVSEQ 107
WP_013161771  22 NTTASKAMYASASQHLAGGVSSSY-QLR---DPWPIYIDRGHQQTIIDVDGNEYIDFHNGYGSMVQGHANPAIGEAVAAR 97 
WP_015884493  82 ASRGLSFGAPTLGEVELAEEIRRRVPPAERVRLVSTGTEATMTAIRLARGVTGRDLVVKFAGCYHGHVDALLAAAGSGLA 161
WP_004214371  90 LENGTLFTHPHELLGEAAEAIKDRWDPIDLVRFTNSGTESTMHAIRVARAYSGREKVLKIEGSYHGAHDYVLLSKSVPAH 169
WP_012825225 104 ARRGFTAMLPGVNTPDVGAALADQF-GLPYWQLATTATDANRFVLRWARAVTGRTKLLVFDGCYHGTVDDTLVDCVVDAE 182
WP_114562996 103 AFTGYTAMLPTADAAIAGKSLTERF-GLPFWQLATTATDANRFVVRWARAITERKKILVFNGCYHGTIDDVFVDLNPNDP 181
WP_004267647 102 IDDGTLYTRPSDLIEFAAQPLLDRWEAIEQVRFTNSGTESVMHSMRLARAATGREKIIRMEGAYHGAHDPALVSKMPPLD 181
WP_020458592 115 MALGSHFAMPTEDSVLVSEELARRF-GLPQWRYVNSGSEATMDAIRIARGVTGRDTIVKIFGSYHGHHDYVMVSIGTPYG 193
BAJ50901      97 IENGTIYGFESEASVKTAKVLTERF-GYERVRFATTGLEATMLAVRLARAFTGRKKILKFEGCFHGSHEPLMVSVKPNIY 175
BAV83475      98 YGKGTHFAAPTEDALAVAENLSSRW-GLPKWRYTNSGSESTMDAIRIARAYTGRDTVMKIFGSYHGHHDTVMVSIGVEYD 176
YP_885070    108 VRRGTHFAQPTENAIWIAEELSRRF-GLPLWRFANSGTEATMDAVHLARAVTGRDLIIKVEGCYHGHHDSVQVSVLPEAD 186
WP_013161771  98 FPLGTHFGMATEDSSIVASELAERW-GLAKWRFTNSGSESTMDAIRIARAYTGRDTIMKIFGSYHGHHDAVMVSIGVEYD 176
WP_015884493 162 TLA--------LPGSAGVTPATAAETLVLPYGDVPSLEA---AFAAHDGRIAAVITEAAPANMGVVEPG-TFNAEIRRVT 229
WP_004214371 170 KLGhpkq-pttVIESEGVPEAIADTVEIGPWNDLDAIES---ILEENATEIGTLIVEPIVMNVGVTQPHgEYLQGLRELC 245
WP_012825225 183 D-GktvsqtvsRASLIGQTVDLGLNTVAVDFNDLAAVER---EL--SSGEIACLLTEPALTNCGMVPALpGFIARLRELT 256
WP_114562996 182 S-App----stRASLLGQVYDLTQFTDVVEFNDIEAVRE---KL--ASREFACVLTEPALTNCGMVLPRnGFLAQLREAC 251
WP_004267647 182 EAGpadd-ptpIRESRGIPESVPENILLAQYNDAASVER---LLRAHEDEVAGILVEPACFNLGVVEPEdGFLHRLRELA 257
WP_020458592 194 DIGpadh-mnsLAYGAGIPQAVVDLTVPVPFNDAAAMERriaALEAEGRKPACVIMEAAMMNLGVVLPEpGYLEAVREIT 272
BAJ50901     176 RAGhpkt-pnsVPASMGMPQEFADLVTVAPYGDLDAVEK---IMQKHGNDVAGIILEPIAMNMGVVIPPlEFLKGLRRLA 251
BAV83475     177 KIGdrdn-lasLPYGGGIPDATVQMTVPVPFNDAEAMERriiRLTDEGRKPACVIMEPAMMNLGVVLPEpGYLEQVREIT 255
YP_885070    187 EVGprah-pvgVPGTSGIPEAIRNLVVVVPFNDPEAVAR---ALTEHRGQVAAMILEPVMMNAGIIPPAdGYLAEIRDLL 262
WP_013161771 177 KIGpreh-pasLAYGGGIPQAIVDLTIPVHFNDAETMEKrivELEAEGRKPACVIMEAVMMNLGVVLPEpGYLEAVREIT 255
WP_015884493 230 AAHGALMICDEVLTGFRTGPSGWWGVEndvadgaaalaaaadqgsgarartpatssyspvsdlaadvrarrddplaadaG 309
WP_004214371 246 DEYNVVLIFDEVKTGVKVAPGGAAEYY----------------------------------------------------G 273
WP_012825225 257 TRYGTLLILDETHT-ISSGRGGWARNA----------------------------------------------------G 283
WP_114562996 252 DATGTLLVFDETHT-ISAGYSGYTGLC----------------------------------------------------D 278
WP_004267647 258 DEFGAVLIFDEVKTGAKIAPGGGAEYY----------------------------------------------------G 285
WP_020458592 273 RRHGIVLIFDEVKTGLCVAAGGAVERF----------------------------------------------------G 300
BAJ50901     252 DEYNSLLIFDEVKTSGKF-YRGVQEWC----------------------------------------------------G 278
BAV83475     256 RRHGVVLIFDEVKTGLCIGPGGATQRF----------------------------------------------------G 283
YP_885070    263 HEAGSLLIYDEVKTGFTAGPGGITALS----------------------------------------------------G 290
WP_013161771 256 RKHGIVLIFDEVKTGLTIAAGGATERF----------------------------------------------------G 283
WP_015884493 310 psttavWTPDLFTFGKVVGGGMPVAAIGGPAAIMDALA------P------LGPVYQAGTLSGNPVAVAAGLATLRLAD- 376
WP_004214371 274 ------VEPDLVTMAKSIGGNTPVGAFGGREDIMREIE-------------NG-AAHYGTYNGNPLVLRAVTTVLNEVLt 333
WP_012825225 284 ------IEPDFVVFGKPIAGGLPAAAYGFSAVLAKRMQaakdaaP------PGHSGIGTTLSGNMLTLAALHATLTEVAt 351
WP_114562996 279 ------FLPDMLVAGKAIAGGLPCAVYGMSESIAQRMRtakeiaP------PGHSGIGTTLSGNMLTMALLATNLTEVAt 346
WP_004267647 286 ------VQPDLVALAKAIGGGYPVGAFGGKRELMELVA------AdlekgvATGAAHYGTYNGNPLSLRAVGVTLREILt 353
WP_020458592 301 ------VLPDMVTLAKALGGGLPAGAIGATAELMAAVA-------------EDRVKQVGTFNGNPLVMAAARASLTEVLt 361
BAJ50901     279 ------VKGDIMVAAKSIAGGYPFSAVLSSKEVFDYVG-------------PNKTAHGGTFNSNPLSVNAAHVTLTKILt 339
BAV83475     284 ------VTPDLVTMAKALGGGLPSGAIGGTEEVMSVVE-------------DHTVFQVGTYNGNPLVMAAVRANLEKVLn 344
YP_885070    291 ------VVPDIVCLAKALGGGIAVAAIGGTTQVMSAIA-------------DGRYEQVGTFNGNPLAMAATRATLSEVLt 351
WP_013161771 284 ------VKPDLVTLAKALGGGLPAGAVGGTEEVMRVVE-------------DHTVYQVGTYSGNPLSMAAARASLEKVLv 344
WP_015884493 377 DAVYARLADTSRAVRTGLTEALDAVGLAHAVSSAASLFSVAFRDERPRGWDDV-QAQ-ETFRYPAFFHAMLDAGVALPP- 453
WP_004214371 334 DDAYDHVDALGDRLASGYEEIMADEGLAGHVEQVNSQGIVVFTDEEINNYRDFdEHV-DVEFHENYWFAMLERGVLPHP- 411
WP_012825225 352 PAAYEHMLTLAATLEQGLTALLARHALPWCITRIGARLELQFCPTAPVNAREA-RAAqQDELEHAIHLYLLNRGVLLTPf 430
WP_114562996 347 KEAFNQIIVQQSKLSAGLRDIIDRNALSWSVTQLGARSEFQFCATSPKNGSEA-ETAmDAELEQAIHLYLLNRGVMITPf 425
WP_004267647 354 DDAYDHVTELSERLADGYRDVMADADIDGYVVTVGSQGMVYFTDERVRTFRDW-EHV-DEELHEAYWFGMLNRGVIPHP- 430
WP_020458592 362 PDAYAHLDRLNDRLVDGCTAILARHGIAGYAVGISSKGCVHFTDAPIRDYTSF-MAHqNAVLPELAWLYNANRQVLMAP- 439
BAJ50901     340 VDNLRHAQTLSKELAKGYSDILEEAKITHNITHIATSGTIYFTEHPIRNWRDF-VKFnDFGKWFAWVVGMLAYGVIPQAl 418
BAV83475     345 PEAYAHLDHLNDRILAGCTEVIERYNLPGYAVGVGGKGCVTFSPKKVVDYESF-KEHqNAELSELAWLFNMNRGIFMTP- 422
YP_885070    352 DESYAHLNRLAGDLRARLASVIAEHGVDWHVVSVGAKGCVTFRKEPVREYRDF-LQI-DDRLGHLHWLMQHNGGVFLPPw 429
WP_013161771 345 PSAYEHLNHLNERLLAGCQNVIDKYGLPGYSVGIGAKGCVTFSPTKIIDYPSF-KENqDVELSELAWLWNMNRGIYMTP- 422
WP_015884493 454 S-VFEAWFVSAAHDDAAVGRVLDALPGAARAAAAV 487
WP_004214371 412 HhASQQWTISVQHEDEHIDRHLEAFKDVAPMLAEQ 446
WP_012825225 431 H---NMMLVCPETRPADIDKLLTVLDDCLSTLTAH 462
WP_114562996 426 H---NMTLVCPETSDADIEQFLMAFESCVKELCQp 457
WP_004267647 431 HdASQQWTISVQHTTDEIDAHIDSFADLATHLSAA 465
WP_020458592 440 G-REEEWTLSVQHTDADVDRYLASLDAMAADLARG 473
BAJ50901     419 G-YDEQWTVSVQHTREDVEKALEAMKNVVKQLKDA 452
BAV83475     423 G-REEEWTLSVTHTDEAIDAYVSCFEELAEAITSK 456
YP_885070    430 G-KVEQWLLSVQHDTADVDRFVANFARLAAAVTR- 462
WP_013161771 423 G-REEEWTLSVTHQDADVDRYIEVFDEMAAAITK- 455
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