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Ebola virus-specific transcription factor VP30 VP30 is a nucleocapsid-associated Ebola virus-specific transcription factor. It acts by stabilising nascent mRNA in Ebola virus replication. The C terminal domain of VP30 folds into a dimeric helical assembly. VP30 assembles into hexamers in solution by an N-terminal oligomerization domain which activates the transcription function of the protein. The oligomerization is mediated by hydrophobic amino acids at 94-112.
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PubMed References
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Jiyao W et al.(2023). "The conserved domain database in 2023.",