Conserved Protein Domain Family
HemA

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COG0373: HemA 
Glutamyl-tRNA reductase [Coenzyme transport and metabolism]
Glutamyl-tRNA reductase is part of the Pathway/BioSystem: Heme biosynthesis
Statistics
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PSSM-Id: 440142
Aligned: 666 rows
Threshold Bit Score: 249.259
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_014910026   1 M---------------------SVLAVGLSHRSSPVALLERVALNGearSRAVGEMVGSDAVNEVMVVSTCNRTEIYADV 59 
YP_169233      3 M---------------------ALISLAIDYKKSPIEVRSEFALSGldvSMLYRSILAIDNVVHAVILSTCNRTEVYLEI 61 
WP_011953572   1 M---------------------YLMCVSLNYHQLPLDLREKFSFTKeevPKADKLLNDEKSILENLLISTCNRTEVYAVV 59 
NP_465082      1 M---------------------FILTMGLNHHTAPIDIREKLVFKEteeEMALVTLQQEKSILENVIISTCNRTEIVAVV 59 
WP_014215834   1 M---------------------FLICMGLDYHKTPIKIRESMYFKEnqlSEADQMLFAEKSILENVILSTCERTEVYAVV 59 
WP_016356482   1 M---------------------KILLYGVSHQTTPIEIRERYTIKEddvPKQLTEIKAFNGVSEVVILTTCNRTEYYLYI 59 
WP_023468973   1 M---------------------HIVVVGLNNKTAPVSIREQVSFGEhemKGAVVALRDEKSIFESVIVSTCNRTELYVVT 59 
WP_039122964   1 M---------------------ALISLAIDYKKSPIEVRSEFSLAGygaKELYNSMLEIDNVCHAVILSTCNRTEIYLEI 59 
WP_069125419   1 M---------------------EVLVATINFKAVSVAHREKFHIDEesvAQAMITLNQQNSVLENVILSTCNRTELYLVV 59 
WP_118991010   1 MirllgegrvtkfirrrgvncvQLVNIGLTSRKTPLTLREKIHFATedlATANQSLSHYKSVLESVILSTCNRTEIFALA 80 
WP_014910026  60 AGYhdGLAAITELLswhsgvslselSEHLYAHYEDQAVQHLFSVTCGLDSMVVGEGQILGQVRDSLKEGQETGSVGRVLN 139
YP_169233     62 SDLr-vVDDILVWWqgyvrnpnykiKDYFKLRQGTEVIMHLMKLACGLESMVLGEPQILGQVKDSYTLSKKNHAIGKELD 140
WP_011953572  60 DQIhtGRYYIRRFLaewfhytiddfTKFVTVTTKDAVAEHLFKVITGLDSLIKGEPQILGQMKDAFQIATKEGTTGAILN 139
NP_465082     60 DQIhtGRYYLKRFManwfqmdmekiEPYLFFHEETEAVNHLYKVTAGLDSLVLGETQILGQVKHAFEIAKQTETTGTLLN 139
WP_014215834  60 DQVhtGKYYIKRFLasefgiamdkiSEYLNVRTGEQAVYHLMELTCGLDSPDIGEPHILGQVKNAFFTAQSSKSTGVLFN 139
WP_016356482  60 DQTefMHGDMLRYIgeytgydvsdvISTSYGKSNSDVATHIFKVATGLDSLMVGETQILSQVKFALKNAQEVATAGPILS 139
WP_023468973  60 DQPhtGRYYTKRFLanwfgltmeelEPYLFIHEGFDAMKHLFRVTSGLDSMIVGETQILGQVKTSFFMAQKLETTGTVFN 139
WP_039122964  60 SDLk-vVDAVLVWWqtyvrdskyalKDYFKLRQGTEVIRHLMKLACGLESMVLGEPQILGQVKDSYTLSKQNGALGKELD 138
WP_069125419  60 DEIsrGRYYVRKYLaalfnmtydevAEQVIFLENDAAIAHLFEVSTSLASMIVGETQILGQVKDSFECAREVNTTGVVLN 139
WP_118991010  81 DQQhtGQYYIKHFIgewfgvpyeslEPYIEIRYNEHMVEHLFLLMTGAQSDVLGETQILGQVRQAYGAAKQAGTTGVILN 160
WP_014910026 140 DLGQRALRVGKRAHTETHLDHAGADMVSFGLTVAS-RHLavtpspdlpfgsvtppagcpmsgqglaeadsaeprsltadl 218
YP_169233    141 RVFQKVFATAKRVRSETRIGHCPVSVAFSAITLAK-RQL----------------------------------------- 178
WP_011953572 140 HLFRQAITFSKRMHTKYRVSELAQSSGQAGLHQIK-MQF----------------------------------------- 177
NP_465082    140 KLFREVVTFAKKVHHHTKINENAVSVSYAAVEVAK-KLY----------------------------------------- 177
WP_014215834 140 HLFKQAISFSKWTHYEYKINEYGETSTQIGLHAAK-TRF----------------------------------------- 177
WP_016356482 140 SLFNKAVSFSKRVHTHTKIDQLSFNPSTAAVELLK-LEW----------------------------------------- 177
WP_023468973 140 KLFKEAVTLAKRAHAETGIGENAVSVSAAAVTLAE-QLL----------------------------------------- 177
WP_039122964 139 RVFQKVFATAKKVRSETRIGHCPVSVAFSAISLAK-KQL----------------------------------------- 176
WP_069125419 140 ELFKRAITVGKQAQSETLIGEGSVSLSTVAVKLIEsQQL----------------------------------------- 178
WP_118991010 161 HLFQQGTAFAKDIHSKYQLNEHPKSLSYQAVELIR-QS------------------------------------------ 197
WP_014910026 219 psGP-LTGTRVLVLGAGSMSALSANTVAR-QGAGTVIVANRTHERAARLAEClneayetV-RA--D-------------T 280
YP_169233    179 --DN-ISSKNVLIIGAGQTGELLFRHVTA-LAPKQIMLANRTIEKAQKITSA-------FrNA--S-------------A 232
WP_011953572 178 --GS-LEGKTLAVVGLGQIGKHTAYNASN-MGFSKVLLLNRTDSKAEQIATE-------L-QGvvE-------------A 232
NP_465082    178 --GS-LDNKKIVLVGAGEMSELALQNLAG-SGIADITIINRTKSNAELLANQ-------F-QA--K-------------V 230
WP_014215834 178 --NK-LEDRKLLIVGAGDMAKQVLQNASG-MGFESIQITNRSLDHAKQLADL-------I-EEevL-------------I 232
WP_016356482 178 --EN-LKEKRILLLGAGKMIRLAAKSLLE-NGAQHITVVSRNSLKAEAFAHD-------M-NEwvQtnyhpeklkryvyS 245
WP_023468973 178 --GS-LEDKSIVVIGAGETGELTTLNLYE-AGARDITVFNRTLAKAEEVANR-------F-EG--S-------------A 230
WP_039122964 177 --DN-ISIKKVLIIGAGQTGELLFRHVTA-LTPKHIMLTNRSLDKAQKITRT-------FaNA--T-------------A 230
WP_069125419 179 ---DmMHKKELVILGAGKMSVLILDYLKPhFPMEQITIVNRTYENAISLAMK-------Y-KT--K-------------A 232
WP_118991010 198 --PN-LEKQTLTLIGLGQVGELVLTYLQE-LPLKNIILVNRTYAKSVRHVSN---------NI--Q-------------A 249
WP_014910026 281 VPFADAAEALPDVDLVISCTGAQGLVLTADAVADATRGR---TRPLVFLDLALPRDIDPAVREREGVHLVDIEDLRQAAA 357
YP_169233    233 HYLSELPQLIKKADIIIAAVNVLEYIVTCKYVg---------DKPRVFIDISIPQALDPKLGELEQNVYYCVDDINAVIE 303
WP_011953572 233 RPFNQLATVVHNVDAAIFAATVKQPLFKADEQIS-----------TMIVDLGVPRNVA--VNST-KLKYYDVDHVHMILN 298
NP_465082    231 GAYENMNEHLMLADIVLVSTSATEPIIKQAAMQDLME-Qk--ASSMLVIDIGLPRNVEHDCSYIPNFHLYDIDDLAGVVS 307
WP_014215834 233 SPITQLQQEIAAADIIVTAWGGRQQLIEPSWAESQGAd----LNEKVFIDLGLPRNIEF-VSNF-TDFYYDLDHLANITT 306
WP_016356482 246 AEYENLPMALAGADGVIVATKASEYIVTTESIIKMQAIRsgsVKELCLIDLAVPRNVDPDLNLVKGIRIFDMDQIAVQID 325
WP_023468973 231 HSINEMQCGLLRADIVISSTGAKRAIIKREDIAAAQLFRh--DRPFLLIDIAVPRDIEPTVGDLPGVHLYDVDDLTSIVQ 308
WP_039122964 231 HTLDQLPELLKEADIIIAAVTIKQYIVTPVDLd---------SKPRVFIDISIPRAIDPNVGSIGQNIYYCVDDIHIVME 301
WP_069125419 233 APKEALQQVLASADVVFSALRSDDYILTQKLLEEQL-------RYLAIVDLGMPRNADPILDVHPQISRYDMDDIERIAD 305
WP_118991010 250 LPWNQLDQGVNQADIVVTALDSVEPLIGADLFPd--------DKIKTVYDLGVPRNVHRDVDALPQIQIYNVDHINHLLD 321
WP_014910026 358 TGTDteaGRSGALTLVRGIVEEEVDEFRAVRRADQVAPTVVALRAQARGVVDAELSRLHGRLPdDldeRTREEIGRAMRR 437
YP_169233    304 DNKD---KRKYESSKAQKIIVKSLEEYLEKEKAIISNSAIKELFQKADGLVDLSLEKSLAKIR-Ng-kDAEEIIKRFAYE 378
WP_011953572 299 SNDE---KRRLMIQKIANEIPQEVNDFYIWEKQLHIVPVIRGLREHSLRIEGEAYDSLLRKLP-EldsHERKVISKHMKS 374
NP_465082    308 ANSL---ERQRIVLELENTIEVEVRNFFEWEKQLGVVPVIRALREKALDMQEVAMTSLENKLP-GlteREYIQIGKHMKS 383
WP_014215834 307 KNHD---LKLHLVKQVKAKIPDQVEEYFLWQKQLNVVPLIRSIRERSTAIQSDVYESLVNKLP-ElndHEQKVIRKHMKS 382
WP_016356482 326 HFKE---EREKIIKGILADIDEAVIKFNRWYKERRAVPYIYQIRKDTMAIREKTIDSLAKKLP-DldaREMKLIDKHMQS 401
WP_023468973 309 QNMA---ERMKEAAKIEQRIEAAIAEFEGWMTTLGVVPIITELRDQALRIQQETMQSLERKLP-EmskREKTVIGKHMKS 384
WP_039122964 302 EGKD---KRKSESTRAQKIIVRSLEEYLEKEKSIISNTAIKELFDKADDIVDISLERSLSKIR-Ng-kDAEEIIKRFAYE 376
WP_069125419 306 QNKQ---QREAAMVEVSKMVVEAQESFHKWRLTLKATPVIHELRDKTLTIYETAMAHMERKLP-NlsdHELKVIHKLTKS 381
WP_118991010 322 THAV---ELEEKIHLIRQEVWQEIEQYFQWQNNLDAVPIVQGLREKMTDHLETVETSLENKLP-DlspREKKVISKHLKS 397
WP_014910026 438 VADKLLHRPTVRVKELAAApdGESYEAALRRLFD-L--Dp-K 475
YP_169233    379 IKKKVLHYPVVGMKEASKQg-RSDCLVCMKRMFG-L--Nv-E 415
WP_011953572 375 IVNQMIKGPIKEIKELSVTpgATADIDFFCKIFG-M--DnlK 413
NP_465082    384 IINQMLKQPISELKEMSVEedATTSIEHFKRIFG-L--Se-T 421
WP_014215834 383 IVNQMLKSPIKEIKELSTLddGDDYLNMLNIIFK-R--Da-- 419
WP_016356482 402 VVNQLIKTPIQSMKEFARMnpSKDMNDALELFVRsIglKq-S 442
WP_023468973 385 IINQLLREPLSYIKDAAAKpdADERIVQFMDTFA-L--Ne-D 422
WP_039122964 377 IKKKVLHYPVMGMKEASKEg-RKDCLVCMKRMFG-L--Nm-E 413
WP_069125419 382 IVNQIIKEPIIKTKELALEedALDKLAFVEHLFG-L--Qt-A 419
WP_118991010 398 LVNAMLKEPVKVTKELMASpqPHEKLSFVADLFG-L--Ei-T 435
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