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From HIV to influenza, the battle between infectious agents and the immune system is at the heart of disease. Knowledge of how and why parasites vary to escape recognition by the immune system is central to vaccine design, the control of epidemics, and our fundamental understanding of parasite ecology and evolution. As the first comprehensive synthesis of parasite variation at the molecular, population, and evolutionary levels, this book is essential reading for students and researchers throughout biology and biomedicine.
The author uses an evolutionary perspective to meld the terms and findings of molecular biology, immunology, pathogen biology, and population dynamics. This multidisciplinary approach offers newcomers a readable introduction while giving specialists an invaluable guide to allied subjects. Every aspect of the immune response is presented in the functional context of parasite recognition and defense—an emphasis that gives structure to a tremendous amount of data and brings into sharp focus the great complexity of immunology. The problems that end each chapter set the challenge for future research, and the text includes extensive discussion of HIV, influenza, foot-and-mouth disease, and many other pathogens.
This is the only book that treats in an integrated way all factors affecting variation in infectious disease. It is a superb teaching tool and a rich source of ideas for new and experienced researchers. For molecular biologists, immunologists, and evolutionary biologists, this book provides new insight into infectious agents, immunity, and the evolution of infectious disease.
Contents
- Acknowledgments
- 1. Introduction
- I. Background
- II. Molecular Processes
- 4. Specificity and Cross-Reactivity
- 4.1 Antigens and Antibody Epitopes
- 4.2 Antibody Paratopes
- 4.3 Antibody Affinity Maturation
- 4.4 Natural Antibodies—Low-Affinity Binding to Diverse Antigens
- 4.5 Affinity versus Specificity
- 4.6 Cross-Reaction of Polyclonal Antibodies to Divergent Antigens
- 4.7 T Cell Epitopes
- 4.8 Every Host Differs
- 4.9 Problems for Future Research
- 5. Generative Mechanisms
- 4. Specificity and Cross-Reactivity
- III. Individual Interactions
- IV. Population Consequences
- V. Studying Evolution
- 11. Classifications by Antigenicity and Phylogeny
- 11.1 Immunological Measures of Antigenicity
- 11.2 Phylogeny
- 11.3 Hypothetical Relations between Immunology and Phylogeny
- 11.4 Immunology Matches Phylogeny over Long Genetic Distances
- 11.5 Immunology-Phylogeny Mismatch with Radiations into New Hosts
- 11.6 Short-Term Phylogenetic Diversification Driven by Immunological Selection
- 11.7 Discordant Patterns of Phylogeny and Antigenicity Created by Within-Host Immune Pressure
- 11.8 Problems for Future Research
- 12. Experimental Evolution: Foot-and-Mouth Disease Virus
- 13. Experimental Evolution: Influenza
- 14. Experimental Evolution: CTL Escape
- 15. Measuring Selection with Population Samples
- 11. Classifications by Antigenicity and Phylogeny
- VI. Discussion
- References
- NLM CatalogRelated NLM Catalog Entries
- Review Third-Kind Encounters in Biomedicine: Immunology Meets Mathematics and Informatics to Become Quantitative and Predictive.[Methods Mol Biol. 2016]Review Third-Kind Encounters in Biomedicine: Immunology Meets Mathematics and Informatics to Become Quantitative and Predictive.Eberhardt M, Lai X, Tomar N, Gupta S, Schmeck B, Steinkasserer A, Schuler G, Vera J. Methods Mol Biol. 2016; 1386:135-79.
- Review Translational Metabolomics of Head Injury: Exploring Dysfunctional Cerebral Metabolism with Ex Vivo NMR Spectroscopy-Based Metabolite Quantification.[Brain Neurotrauma: Molecular, ...]Review Translational Metabolomics of Head Injury: Exploring Dysfunctional Cerebral Metabolism with Ex Vivo NMR Spectroscopy-Based Metabolite Quantification.Wolahan SM, Hirt D, Glenn TC. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. 2015
- Review Protozoa: Pathogenesis and Defenses.[Medical Microbiology. 1996]Review Protozoa: Pathogenesis and Defenses.Seed JR. Medical Microbiology. 1996
- Wild immunology.[Mol Ecol. 2011]Wild immunology.Pedersen AB, Babayan SA. Mol Ecol. 2011 Mar; 20(5):872-80. Epub 2011 Jan 3.
- Principles of Vaccination.[Methods Mol Biol. 2016]Principles of Vaccination.Zepp F. Methods Mol Biol. 2016; 1403:57-84.
- Immunology and Evolution of Infectious DiseaseImmunology and Evolution of Infectious Disease
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