This activity was supported by contracts between the National Academy of Sciences and Air Force Medical Service (Contract No. FA8052-17-P-0007); Centers for Disease Control and Prevention (Contract No. 75D30121D11240, Task Order No. 75D30121F00002); Health Resources and Services Administration (Contract No. HHSH250201500001I, Task Order No. 75R60220F34021); National Institutes of Health (Contract No. HHSN263201800029I, Task Order Nos. HHSN26300010 and HHSN26300008): All of Us Research Program, National Cancer Institute, National Human Genome Research Institute, National Institute of Mental Health, National Institute of Nursing Research, and National Institute on Aging; 23andMe, Inc.; American Academy of Nursing; American Association for Cancer Research; American Cancer Society; American College of Medical Genetics and Genomics; American College of Radiology; American Medical Association; American Society of Clinical Oncology; American Society of Human Genetics; Association for Molecular Pathology; Association of American Cancer Institutes; Association of Community Cancer Centers; Biogen; Blue Cross and Blue Shield Association; Bristol Myers Squibb; Cancer Support Community; College of American Pathologists; Eisai Inc.; Flatiron Health; Geisinger; Genome Medical, Inc.; Helix; Illumina, Inc.; The Jackson Laboratory (JAX); Kaiser Foundation Health Plan, Inc.; Merck & Co., Inc.; Myriad Genetics; National Comprehensive Cancer Network; National Patient Advocate Foundation; National Society of Genetic Counselors; Novartis Oncology; Oncology Nursing Society; Partners in Health; Pfizer, Inc.; Regeneron; Sanofi; Society for Immunotherapy of Cancer; The University of Vermont Health Network Medical Group; University of California, San Francisco; and Vibrent Health. Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any organization or agency that provided support for the project.