This companion to Infectious Diseases of Mice and Rats makes practical information on rodent diseases readily accessible to researchers.

This volume parallels the three parts of the main volume. Part I, Principles of Rodent Disease Prevention, briefly examines the requirements for maintaining pathogen-free rodents, factors in designing health surveillance programs, and other laboratory management issues.

Part II, Disease Agents, is an easy-to-use reference section, listing diagnosis and control methods, the potential for interference with research, and other factors for disease agents ranging from adenoviruses to tapeworms. It covers bacteria, viruses, fungi and common ectoparasites, and endoparasites.

Part III, Diagnostic Indexes, presents alphabetical listings of clinical signs, pathology, and research complications and lists infectious agents that might be responsible for each.

Contents

• COMMITTEE ON INFECTIOUS DISEASES OF MICE AND RATS
• INSTITUTE OF LABORATORY ANIMAL RESOURCES COUNCIL
• COMMISSION ON LIFE SCIENCES
• Preface
• PART I. Principles of Rodent Disease Prevention
  • SCIENTIFIC OBJECTIVES
  • INFECTION VERSUS DISEASE
  • TERMINOLOGY OF MICROBIAL AND PATHOGEN STATUS
  • COMMITMENT TO MAINTAINING PATHOGEN-FREE STATUS OF RODENTS
  • HEALTH SURVEILLANCE PROGRAMS
    • Scientific Objectives
    • Test Procedures
    • Sampling Strategies
    • Test Frequency
    • Sentinel Animals
  • RODENT DIAGNOSTIC LABORATORIES
  • REFERENCES
• PART II. Disease Agents
  • BACTERIA, FUNGI, AND VIRUSES
    • Adenoviruses
    • Suggested Reading
    • Bacillus piliformis
    • Suggested Reading
    • Cilia-Associated Respiratory Bacillus
    • Suggested Reading
    • Citrobacterfreundii Biotype 4280
    • Suggested Reading
    • Corynebacterium kutscheri
    • Suggested Reading
    • Cytomegalovirus, Mouse
    • Suggested Reading
    • Ectromelia Virus
    • Suggested Reading
    • Encephalitozoon cuniculi
    • Suggested Reading
    • Hantaviruses
    • Suggested Reading
    • Hepatitis Virus, Mouse
    • Suggested Reading
    • H-1 Virus
    • Suggested Reading
    • Kilham Rat Virus
    • Suggested Reading
    • Lactic Dehydrogenase-Elevating Virus
    • Suggested Reading
    • Leukemia Viruses, Murine
    • Suggested Reading
    • Lymphocytic Choriomeningitis Virus
    • Suggested Reading
    • Mammary Tumor Virus, Mouse
    • Suggested Reading
    • Minute Virus of Mice
    • Suggested Reading
    • Mycoplasma arthritidis
    • Suggested Reading
    • Mycoplasma pulmonis
    • Suggested Reading
    • Pasteurella pneumotropica
    • Suggested Reading
    • Pneumocystis carinii
    • Suggested Reading
    • Pneumonia Virus of Mice
    • Suggested Reading
    • Polyomavirus
    • Suggested Reading
    • Pseudomonas aeruginosa
    • Suggested Reading
    • Reovirus-3
    • Suggested Reading
    • Rotavirus, Mouse
    • Suggested Reading
    • Salmonella enteritidis
    • Suggested Reading
    • Sendai Virus
    • Suggested Reading
    • Sialodacryoadenitis Virus
    • Suggested Reading
    • Staphylococcus aureus
    • Suggested Reading
    • Streptobacillus moniliformis
    • Suggested Reading
    • Streptococcus pneumoniae
    • Suggested Reading
    • Theiler's Murine Encephalomyelitis Virus
    • Suggested Reading
    • Thymic Virus, Mouse
    • Suggested Reading
  • DERMATOPHYTES
    • Trichophyton spp. and Microsporum spp.
    • Suggested Reading
  • COMMON ECTOPARASITES
    • Myobia musculi
    • Suggested Reading
    • Myocoptes musculinus and Radfordia affinis
    • Suggested Reading
    • Other Ectoparasites
    • Suggested Reading
  • ENDOPARASITES
    • Aspicularis tetraptera (Mouse Pinworm)
    • Suggested Reading
    • Entamoeba muris
    • Suggested Reading
    • Giardia muris
    • Suggested Reading
    • Hymenolepis nana
    • Suggested Reading
    • Spironucleus muris
    • Suggested Reading
    • Syphacia obvelata (Mouse Pinworm) and Syphacia muris (Rat Pinworm)
    • Suggested Reading
    • Trichomonas muris
    • Suggested Reading
    • Other Endoparasites
    • Suggested Reading
• PART III. Diagnosis and Research Complications of Infectious Agents
  • INTRODUCTION
  • CLINICAL SIGNS
  • PATHOLOGY
  • RESEARCH COMPLICATIONS

NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, National Academy of Engineering, and Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.

This report has been reviewed by a group other than the authors according to procedures approved by a Report Review Committee consisting of members of the National Academy of Sciences, National Academy of Engineering, and Institute of Medicine.

The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that requires it to advise the federal government on scientific and technical matters. Dr. Frank Press is president of the National Academy of Sciences.

The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers. It is autonomous in its administration and in the selection of its members, sharing with the National Academy of Sciences the responsibility for advising the federal government. The National Academy of Engineering also sponsors engineering programs aimed at meeting national needs, encourages education and research, and recognizes the superior achievements of engineers. Dr. Robert M. White is president of the National Academy of Engineering.

The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public. The Institute acts under the responsibility given to the National Academy of Sciences by its congressional charter to be an adviser to the federal government and upon its own initiative to identify issues of medical care, research, and education. Dr. Samuel O. Thier is president of the Institute of Medicine.

The National Research Council was established by the National Academy of Sciences in 1916 to associate the broad community of science and technology with the Academy's purposes of furthering knowledge and advising the federal government. Functioning in accordance with general policies determined by the Academy, the Council has become the principal operating agency of both the National Academy of Sciences and National Academy of Engineering in the conduct of their services to the government, the public, and the scientific and engineering communities. The Council is administered jointly by both Academies and the Institute of Medicine. Dr. Frank Press and Dr. Robert M. White are chairman and vice-chairman, respectively, of the National Research Council.