OVERVIEW

PRODUCT INFORMATION

CHEMICAL FORMULA AND STRUCTURE

View in own window

DRUG	CAS REGISTRY NUMBER	MOLECULAR FORMULA	STRUCTURE
Reserpine	50-55-5	C33-H40-N2-O9

ANNOTATED BIBLIOGRAPHY

References updated: 21 May 2018

• Zimmerman HJ. Drugs used in cardiovascular disease. In, Zimmerman HJ. Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver. 2nd ed. Philadelphia: Lippincott, 1999, pp. 639-71.

  (Expert review of hepatotoxicity published in 1999; reserpine rarely causes significant liver injury, only two case reports having been published despite its wide use).
• De Marzio DH, Navarro VJ. Hepatotoxicity of cardiovascular and antidiabetic drugs: antihypertensives. In, Kaplowitz N, DeLeve LD, eds. Drug-induced liver disease. 3rd ed. Amsterdam: Elsevier, 2013, pp. 519-40.

  (Review of hepatotoxicity of hypertensive agents; reserpine is not discussed).
• Michel T, Hoffman BB. Therapy of myocardial ischemia and hypertension. In, Brunton LL, Lazo JS, Parker KL, eds. Goodman & Gilman’s the pharmacological basis of therapeutics. 12th ed. New York: McGraw-Hill, 2011, pp. 745-88.

  (Textbook of pharmacology and therapeutics; “reserpine was the first drug that was found to interfere with the function of the sympathetic nervous system in human beings, and its use began the modern era of effective pharmacotherapy of hypertension”).
• Nagler A, Enat R. [Liver damage due to reserpine hypersensitivity]. Harefuah 1984; 107: 130-1. Hebrew. [PubMed: 6510817]

  (52 year old woman developed jaundice 1 year after starting combination of dihydralazine and reserpine for hypertension [bilirubin 8 mg/dL, AST 480 U/L, Alk P 263 U/L], resolving within 1 month of stopping and recurring after 1 month of restarting both; may have been due to dihydralazine, but positive in vitro reactions occurred with reserpine alone).
• Moeckel W. [On the clinical picture of jaundice with intrahepatic cholestasis caused by drugs]. Med Klin 1965; 60: 294-8. German. [PubMed: 14258124]

  (Five cases of drug induced cholestatic hepatitis; case 3 was 66 year old man who developed jaundice after being on reserpine, phenobarbital and quinidine for one year [bilirubin 17.4 mg/dL, Alk P 2 times ULN, eosinophils 12%]; while phenobarbital and quinidine can also cause liver injury, the case was attributed to reserpine on the basis of in vitro stimulation tests).
• Drugs for hypertension. Treat Guidel Med Lett 2009; 7: 1-10. [PubMed: 19107095]

  (Brief overview of currently available drugs for hypertension with guidelines on their use and information on prices and toxicities: “Reserpine is an effective antihypertensive, but is seldom used now because in doses much higher than currently recommended, it can cause severe depression”).
• Hernández N, Bessone F, Sánchez A, di Pace M, Brahm J, Zapata R, A Chirino R, et al. Profile of idiosyncratic drug induced liver injury in Latin America. An analysis of published reports. Ann Hepatol 2014; 13: 231-9. [PubMed: 24552865]

  (Systematic review of literature of drug induced liver injury in Latin American countries published from 1996 to 2012 identified 176 cases; no cases were attributed to reserpine).
• Chalasani N, Bonkovsky HL, Fontana R, Lee W, Stolz A, Talwalkar J, Reddy KR, et al.; United States Drug Induced Liver Injury Network. Features and outcomes of 899 patients with drug-induced liver injury: The DILIN Prospective Study. Gastroenterology 2015; 148: 1340-52.e7. [PMC free article: PMC4446235] [PubMed: 25754159]

  (Among 899 cases of drug induced liver injury enrolled in a US prospective study between 2004 and 2013, 39 [4%] were due to antihypertensive agents but none were believed to be due to reserpine).
• Drugs for hypertension. Med Lett Drugs Ther 2017; 59 (1516): 41-8. [PubMed: 28263286]

  (Concise overview of the currently available drugs for hypertension with guidelines on their use and information on prices and toxicities; reserpine is not discussed).