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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 166663-25-8
Drug Levels and Effects
Summary of Use during Lactation
Because of the low levels of anidulafungin in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants. If anidulafungin is required by the mother, it is not a reason to discontinue breastfeeding.
Drug Levels
Maternal Levels. A postpartum woman was treated with intravenous anidulafungin 100 mg once daily for 14 days. Nine milk samples were obtained over the first 32 hours after the drug was discontinued. Five hours after drug was discontinued, the milk concentration of anidulafungin was 0.24 mg/L. The concentration decreased to 0.12 mg/L at 32 hours after the dose and was undetectable in milk at 38 and 48 hours after the dose.[1]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
A postpartum woman was treated with intravenous anidulafungin 100 mg once daily for 14 days. She withheld breastfeeding until the second day after completing her 14-day course of therapy. Her milk had detectable anidulafungin levels until 32 hours after the last dose. No gastrointestinal or other adverse effects were seen in the infant up to 72 hours after the last dose of drug.[1]
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
References
- 1.
- Eijsink JFH, Wieringa A, Vries-Koenjer MLM, Ter Horst PGJ. Anidulafungin levels in breast milk after cessation of treatment: A case report. Breastfeed Med 2024;19:134-6. [PubMed: 38174985]
Substance Identification
Substance Name
Anidulafungin
CAS Registry Number
166663-25-8
Drug Class
Breast Feeding
Lactation
Milk, Human
Antifungal Agents
Echinocandins
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Antifungal activity of the echinocandin anidulafungin (VER002, LY-303366) against yeast pathogens: a comparative study with M27-A microdilution method.[J Antimicrob Chemother. 2003]Antifungal activity of the echinocandin anidulafungin (VER002, LY-303366) against yeast pathogens: a comparative study with M27-A microdilution method.Arévalo MP, Carrillo-Muñoz AJ, Salgado J, Cardenes D, Brió S, Quindós G, Espinel-Ingroff A. J Antimicrob Chemother. 2003 Jan; 51(1):163-6.
- In vitro activity of voriconazole, itraconazole, caspofungin, anidulafungin (VER002, LY303366) and amphotericin B against aspergillus spp.[Diagn Microbiol Infect Dis. 2003]In vitro activity of voriconazole, itraconazole, caspofungin, anidulafungin (VER002, LY303366) and amphotericin B against aspergillus spp.Serrano Mdel C, Valverde-Conde A, Chávez M M, Bernal S, Claro RM, Pemán J, Ramirez M, Martín-Mazuelos E. Diagn Microbiol Infect Dis. 2003 Feb; 45(2):131-5.
- Anidulafungin - Drugs and Lactation Database (LactMed®)Anidulafungin - Drugs and Lactation Database (LactMed®)
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