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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 5714-73-8
Drug Levels and Effects
Summary of Use during Lactation
Methenamine passes into milk in small quantities and appears safe to use, even while nursing a newborn.
Drug Levels
Maternal Levels. Six mothers nursing newborn infants were given methenamine hippurate 1 gram orally. Five hours after the dose, a mean methenamine concentration of 7 mg/L was found in milk. In two other women, milk concentrations averaged 9.1 mg/L at 2 to 3 hours after a 1 gram dose of methenamine hippurate orally and 4.3 mg/L at 6 to 7 hours after the dose. Based on the amount of milk ingested, the authors calculated the dose the infants received to be 0.05 to 0.1 mg/kg, which is about 1% of the adult dose.[1]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Four newborn infants were allowed to breastfeed in one study after a maternal dose of 1 gram of methenamine hippurate. No adverse effects were reported.[1]
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
References
- 1.
- Allgén LG, Holmberg G, Persson B, et al. Biological fate of methenamine in man. Acta Obstet Gynecol Scand. 1979;58:287–93. [PubMed: 484222]
Substance Identification
Substance Name
Methenamine Hippurate
CAS Registry Number
5714-73-8
Drug Class
Breast Feeding
Lactation
Anti-Infective Agents, Urinary
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- The antibacterial activity of hexamine (methenamine), hexamine hippurate and hexamine mandelate.[Infection. 1981]The antibacterial activity of hexamine (methenamine), hexamine hippurate and hexamine mandelate.Greenwood D, Slack RC. Infection. 1981; 9(5):223-7.
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