Attribution Statement: LactMed is a registered trademark of the U.S. Department of Health and Human Services.
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
Drug Levels and Effects
Summary of Use during Lactation
The Centers for Disease Control and Prevention and the several health professional organizations state that vaccines given to a nursing mother do not affect the safety of breastfeeding for mothers or infants.[1-5] A slightly higher percentage of infants who were breastfed during or after maternal vaccination with the active quadrivalent human papillomavirus vaccine (Gardasil) had pneumonia during the 30 days after maternal vaccination, but these effects were not thought to be vaccine related. No similar data exist for the bivalent vaccine (Cervarix). Maternal vaccination with human papillomavirus vaccine is not a contraindication to breastfeeding.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
A total of 995 nursing mothers were given Gardasil or placebo during the vaccination period of the clinical trials (vaccine n = 500, control n = 495). A total of 17 (3.4%) and nine (1.8%) infants of women who breastfed who received quadrivalent HPV vaccine or placebo, respectively, experienced a serious adverse event. Of the 23 experiences among the 17 infants of women who received vaccine, 12 were respiratory infections, five were gastroenteritis or diarrhea, and the remaining included various other single events. None of the reactions was considered vaccine related.[6,7]
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- Kimberlin DW, Brady MT, Jackson MA, et al. Red Book: 2018 Report of the Committee on Infectious Diseases. 31st ed. Elk Grove Village, IL: American Academy of Pediatrics. 2018.
- 2.
- Gruslin A, Steben M, Halperin S, et al. Immunization in pregnancy: No. 220, December 2008. Int J Gynaecol Obstet 2009;105:187-91. [PubMed: 19367691]
- 3.
- Harpaz R, Ortega-Sanchez IR, Seward JF. Prevention of Herpes zoster: Recommendations of the advisory committee on immunization practices (ACIP). MMWR Recomm Rep 2008;57 (RR-5):1-30. [PubMed: 18528318]
- 4.
- Committee opinion no. 467: Human papillomavirus vaccination. Obstet Gynecol 2010;116:800-3. [PubMed: 20733476]
- 5.
- Kroger A, Bahta L, Long S, et al. CDC. General Best Practices for Immunization. https://www
.cdc.gov/vaccines /hcp/acip-recs /general-recs/index.html - 6.
- Markowitz LE, Dunne EF, Saraiya M, et al. Quadrivalent human papillomavirus vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2007;56 (RR-2):1-24. [PubMed: 17380109]
- 7.
- Garland SM, Ault KA, Gall SA, et al. Pregnancy and infant outcomes in the clinical trials of a human papillomavirus type 6/11/16/18 vaccine: a combined analysis of five randomized controlled trials. Obstet Gynecol 2009;114:1179-88. [PubMed: 19935017]
Substance Identification
Substance Name
Human Papillomavirus Vaccines
Drug Class
Breast Feeding
Lactation
Milk, Human
Vaccines
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
- User and Medical Advice Disclaimer
- Drugs and Lactation Database (LactMed) - Record Format
- LactMed - Database Creation and Peer Review Process
- Fact Sheet. Drugs and Lactation Database (LactMed)
- Drugs and Lactation Database (LactMed) - Glossary
- LactMed Selected References
- Drugs and Lactation Database (LactMed) - About Dietary Supplements
- Breastfeeding Links
- PubMedLinks to PubMed
- Neutralizing and cross-neutralizing antibody titres induced by bivalent and quadrivalent human papillomavirus vaccines in the target population of organized vaccination programmes.[Vaccine. 2014]Neutralizing and cross-neutralizing antibody titres induced by bivalent and quadrivalent human papillomavirus vaccines in the target population of organized vaccination programmes.Barzon L, Squarzon L, Masiero S, Pacenti M, Marcati G, Mantelli B, Gabrielli L, Pascucci MG, Lazzarotto T, Caputo A, et al. Vaccine. 2014 Sep 15; 32(41):5357-62. Epub 2014 Jul 18.
- Comparison of the immunogenicity and safety of Cervarix and Gardasil human papillomavirus (HPV) cervical cancer vaccines in healthy women aged 18-45 years.[Hum Vaccin. 2009]Comparison of the immunogenicity and safety of Cervarix and Gardasil human papillomavirus (HPV) cervical cancer vaccines in healthy women aged 18-45 years.Einstein MH, Baron M, Levin MJ, Chatterjee A, Edwards RP, Zepp F, Carletti I, Dessy FJ, Trofa AF, Schuind A, et al. Hum Vaccin. 2009 Oct; 5(10):705-19. Epub 2009 Oct 14.
- Cost-effectiveness of the introduction of two-dose bi-valent (Cervarix) and quadrivalent (Gardasil) HPV vaccination for adolescent girls in Bangladesh.[Vaccine. 2020]Cost-effectiveness of the introduction of two-dose bi-valent (Cervarix) and quadrivalent (Gardasil) HPV vaccination for adolescent girls in Bangladesh.Mahumud RA, Gow J, Alam K, Keramat SA, Hossain MG, Sultana M, Sarker AR, Islam SMS. Vaccine. 2020 Jan 10; 38(2):165-172. Epub 2019 Oct 24.
- Review Influenza Vaccines.[Drugs and Lactation Database (...]Review Influenza Vaccines.. Drugs and Lactation Database (LactMed®). 2006
- Review Cross-protective efficacy of two human papillomavirus vaccines: a systematic review and meta-analysis.[Lancet Infect Dis. 2012]Review Cross-protective efficacy of two human papillomavirus vaccines: a systematic review and meta-analysis.Malagón T, Drolet M, Boily MC, Franco EL, Jit M, Brisson J, Brisson M. Lancet Infect Dis. 2012 Oct; 12(10):781-9. Epub 2012 Aug 22.
- Human Papillomavirus Vaccines - Drugs and Lactation Database (LactMed®)Human Papillomavirus Vaccines - Drugs and Lactation Database (LactMed®)
- Ciclesonide - Drugs and Lactation Database (LactMed®)Ciclesonide - Drugs and Lactation Database (LactMed®)
Your browsing activity is empty.
Activity recording is turned off.
See more...