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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 67227-56-9
Drug Levels and Effects
Summary of Use during Lactation
No information is available on the use of fenoldopam during breastfeeding. The manufacturer recommends avoiding breastfeeding during fenoldopam use; however, because of its poor oral bioavailability and short half-life, any fenoldopam in milk is unlikely to adversely affect the breastfed infant. Also, fenoldopam can be given intravenously to infants. Unlike dopamine, it does not decrease serum prolactin concentrations and might not interfere with nursing.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information in nursing mothers was not found as of the revision date. Unlike dopamine, fenoldopam infusion does not affect serum prolactin concentration in normal women.[1] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Alternate Drugs to Consider
(Hypertension) Enalapril, Hydralazine, Labetalol, Methyldopa, Propranolol
References
- 1.
- Boesgaard S, Hagen C, Hangaard J, et al. Pulsatile gonadotropin secretion and basal prolactin levels during dopamine D-1 receptor stimulation in normal women. Fertil Steril. 1991;55:281–6. [PubMed: 1671361]
Substance Identification
Substance Name
Fenoldopam
CAS Registry Number
67227-56-9
Drug Class
Breast Feeding
Lactation
Antihypertensive Agents
Dopamine Agents
Dopamine Agonists
Vasodilator Agents
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Intracellularly recorded response of rat striatal neurons in vitro to fenoldopam and SKF 38393 following lesions of midbrain dopamine cells.[Synapse. 1994]Intracellularly recorded response of rat striatal neurons in vitro to fenoldopam and SKF 38393 following lesions of midbrain dopamine cells.Twery MJ, Thompson LA, Walters JR. Synapse. 1994 Sep; 18(1):67-78.
- Pulsatile gonadotropin secretion and basal prolactin levels during dopamine D-1 receptor stimulation in normal women.[Fertil Steril. 1991]Pulsatile gonadotropin secretion and basal prolactin levels during dopamine D-1 receptor stimulation in normal women.Boesgaard S, Hagen C, Hangaard J, Andersen AN, Eldrup E. Fertil Steril. 1991 Feb; 55(2):281-6.
- Fenoldopam is a partial agonist at dopamine-1 (DA1) receptors in LLC-PK1 cells.[J Pharmacol Exp Ther. 1991]Fenoldopam is a partial agonist at dopamine-1 (DA1) receptors in LLC-PK1 cells.Grenader A, Healy DP. J Pharmacol Exp Ther. 1991 Jul 1; 258(1):193-8.
- Review Clinical experience with intravenous fenoldopam.[Am J Hypertens. 1990]Review Clinical experience with intravenous fenoldopam.Holcslaw TL, Beck TR. Am J Hypertens. 1990 Jun; 3(6 Pt 2):120S-125S.
- Review Dopamine.[Drugs and Lactation Database (...]Review Dopamine.. Drugs and Lactation Database (LactMed®). 2006
- Fenoldopam - Drugs and Lactation Database (LactMed®)Fenoldopam - Drugs and Lactation Database (LactMed®)
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