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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 38821-53-3
Drug Levels and Effects
Summary of Use during Lactation
Limited information indicates cephradine produces low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with cephalosporins, but these effects have not been adequately evaluated. cephradine is acceptable in nursing mothers.
Drug Levels
Maternal Levels. Six women were given cephradine 500 mg orally every 6 hours for 9 doses. Milk levels after the last dose were essentially constant for the 6 hours following the dose with a range of 0.62 to 0.68 mg/L.[1,2]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
References
- 1.
- Mischler TW, Corson SL, Bolognese RJ, et al. Presence of cephradine in body fluids of lactating and pregnant women. Clin Pharmacol Ther 1974;15:214. doi:10.1002/cpt1974152200 [CrossRef]
- 2.
- Mischler TW, Corson SL, Larranaga A, et al. Cephradine and epicillin in body fluids of lactating and pregnant women. J Reprod Med 1978;21:130-6. [PubMed: 569206]
Substance Identification
Substance Name
Cephradine
CAS Registry Number
38821-53-3
Drug Class
Breast Feeding
Lactation
Milk, Human
Anti-Infective Agents
Antibacterial Agents
Cephalosporins
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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