U.S. flag

An official website of the United States government

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.

Cover of Drugs and Lactation Database (LactMed®)

Drugs and Lactation Database (LactMed®) [Internet].

Show details

Pegvisomant

Last Revision: November 30, 2022.

Estimated reading time: 1 minute

CASRN: 218620-50-9

Drug Levels and Effects

Summary of Use during Lactation

Limited data indicate that pegvisomant is poorly excreted into breastmilk. Because pegvisomant is not orally absorbed, it is unlikely to adversely affect the breastfed infant. Polyethylene glycol is not excreted into breastmilk.[1]

Drug Levels

A woman was being treated during pregnancy for acromegaly with subcutaneous pegvisomant at a dosage that was progressively escalated from 15 mg to 25 mg daily during the course of pregnancy, and presumably postpartum. At an unreported time postpartum, pegvisomant was not detectable (<50 mcg/L) in breastmilk. The patient's breastmilk growth hormone concentration was 0.6 mcg/L compared to <0.1 mcg/L in 3 breastmilk samples from normal healthy mothers.[2]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

A woman with acromegaly was treated with lanreotide Autogel 120 mg monthly, cabergoline 2 mg weekly and pegvisomant 80 mg weekly. She breastfed (extent not stated) her infant and they were followed for 12 years. Her child had normal growth and development.[3]

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1.
Clowse ME, Förger F, Hwang C, et al. Minimal to no transfer of certolizumab pegol into breast milk: Results from CRADLE, a prospective, postmarketing, multicentre, pharmacokinetic study. Ann Rheum Dis. 2017;76:1890–6. [PMC free article: PMC5705850] [PubMed: 28814432]
2.
Brian SR, Bidlingmaier M, Wajnrajch MP, et al. Treatment of acromegaly with pegvisomant during pregnancy: Maternal and fetal effects. J Clin Endocrinol Metab. 2007;92:3374–7. [PubMed: 17595256]
3.
Popescu AD, Carsote M, Valea A, et al. Approach of acromegaly during pregnancy. Diagnostics (Basel). 2022;12:2669. [PMC free article: PMC9689290] [PubMed: 36359512]

Substance Identification

Substance Name

Pegvisomant

CAS Registry Number

218620-50-9

Drug Class

Breast Feeding

Lactation

Milk, Human

Human Growth Hormone Analogues and Derivatives

Growth Hormone Receptor Antagonists

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Copyright Notice

Attribution Statement: LactMed is a registered trademark of the U.S. Department of Health and Human Services.

Bookshelf ID: NBK501495PMID: 30000555

Views

Related information

  • PMC
    PubMed Central citations
  • PubMed
    Links to PubMed

Similar articles in PubMed

  • Review Peginterferon Alfa.[Drugs and Lactation Database (...]
    Review Peginterferon Alfa.
    . Drugs and Lactation Database (LactMed®). 2006
  • Review Teicoplanin.[Drugs and Lactation Database (...]
    Review Teicoplanin.
    . Drugs and Lactation Database (LactMed®). 2006
  • Review Butorphanol.[Drugs and Lactation Database (...]
    Review Butorphanol.
    . Drugs and Lactation Database (LactMed®). 2006
  • Review Miglitol.[Drugs and Lactation Database (...]
    Review Miglitol.
    . Drugs and Lactation Database (LactMed®). 2006
  • Review Octreotide.[Drugs and Lactation Database (...]
    Review Octreotide.
    . Drugs and Lactation Database (LactMed®). 2006
See reviews...See all...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...