NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
Figure 6Compound 1 (ML171) treatment significantly blocks invadopodia formation in DLD1 cells
(a) Cells were stained with Alexa-Fluor-568 phalloidin (left column) or cortactin (right column) antibody, followed by Alexa-Fluor 568-conjugated secondary antibody and visualized by confocal miscroscopy (100X). White arrows indicate phalloidin-positive (right column) or cortactin-positive (left column) invadopodia. Scale bars, 5 μm. One representative picture from three separate experiments is shown. (b) Quantification from three independent biological experiments shown in (a) is given: the number of phalloidin positive-invadopodia (left panel) or cortactin positive-invadopodia (right panel) was counted and averaged from 50 cells/condition for each experiment. Error bars represent SEM: *p<0.001. Figure reproduced with permission from the American Chemical Society.
- PMCPubMed Central citations
- PubChem BioAssay for Chemical ProbePubChem BioAssay records reporting screening data for the development of the chemical probe(s) described in this book chapter
- PubChem SubstanceRelated PubChem Substances
- PubMedLinks to PubMed
- A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells.[ACS Chem Biol. 2010]A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells.Gianni D, Taulet N, Zhang H, DerMardirossian C, Kister J, Martinez L, Roush WR, Brown SJ, Bokoch GM, Rosen H. ACS Chem Biol. 2010 Oct 15; 5(10):981-93.
- Identification and Characterization of a Novel NADPH Oxidase 1 (Nox1) Inhibitor That Suppresses Proliferation of Colon and Stomach Cancer Cells.[Biol Pharm Bull. 2018]Identification and Characterization of a Novel NADPH Oxidase 1 (Nox1) Inhibitor That Suppresses Proliferation of Colon and Stomach Cancer Cells.Yamamoto T, Nakano H, Shiomi K, Wanibuchi K, Masui H, Takahashi T, Urano Y, Kamata T. Biol Pharm Bull. 2018 Mar 1; 41(3):419-426. Epub 2017 Dec 22.
- A subset of N-substituted phenothiazines inhibits NADPH oxidases.[Free Radic Biol Med. 2015]A subset of N-substituted phenothiazines inhibits NADPH oxidases.Seredenina T, Chiriano G, Filippova A, Nayernia Z, Mahiout Z, Fioraso-Cartier L, Plastre O, Scapozza L, Krause KH, Jaquet V. Free Radic Biol Med. 2015 Sep; 86:239-49. Epub 2015 May 23.
- Review Probe Report for NOX1 Inhibitors.[Probe Reports from the NIH Mol...]Review Probe Report for NOX1 Inhibitors.Brown SJ, Gianni D, Bokoch G, Mercer BA, Hodder P, Rosen HR. Probe Reports from the NIH Molecular Libraries Program. 2010
- Review The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology.[Physiol Rev. 2007]Review The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology.Bedard K, Krause KH. Physiol Rev. 2007 Jan; 87(1):245-313.
- Figure 6, Compound 1 (ML171) treatment significantly blocks invadopodia formatio...Figure 6, Compound 1 (ML171) treatment significantly blocks invadopodia formation in DLD1 cells - Probe Reports from the NIH Molecular Libraries Program
Your browsing activity is empty.
Activity recording is turned off.
See more...