Figure 2, GABABRs involvement in the tonic GABAA current of TC neurons in genetic and pharmacological models of typical absence seizures - Jasper's Basic Mechanisms of the Epilepsies

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Noebels JL, Avoli M, Rogawski MA, et al., editors. Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012.

This title is an author manuscript version first made accessible on the NCBI Bookshelf website July 2, 2012.

This title is an author manuscript version first made accessible on the NCBI Bookshelf website July 2, 2012.

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Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition.

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Figure 2GABA_BRs involvement in the tonic GABA_A current of TC neurons in genetic and pharmacological models of typical absence seizures

A. Current traces form TC neurons of normal Wistar rat showing the GHB-elicited increase in tonic GABA_A current and its block by the GABA_B antagonists CGP55845 (10 μM). B. Comparison of the effects of different concentrations of GHB on tonic GABA_A current amplitude in normal Wistar rats, and its block by CGP55845 (10 μM). Note how CGP55845 alone decreases tonic current amplitude compared to control conditions. Values are normalised to the average tonic current in the absence of GHB or CGP55845. C. Effect of bath application of 10 μM CGP55845 on tonic GABA_A current in GAERS, stargazer (stg) and lethargic (lh) mice. Values are normalised to the average tonic current amplitude in the absence of CGP55845. B and C: * p<0.05, ** p<0.01 and *** p<0.001. (A-C: reproduced with permission from Cope et al., 2009, ©Nature Publishing Group).

From: GABA-A Receptor Function in Typical Absence Seizures

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Crunelli V, Leresche N, Cope DW. GABA-A Receptor Function in Typical Absence Seizures. In: Noebels JL, Avoli M, Rogawski MA, et al., editors. Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012. Figure 2, GABABRs involvement in the tonic GABAA current of TC neurons in genetic and pharmacological models of typical absence seizures.
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Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition.

Figure 2GABABRs involvement in the tonic GABAA current of TC neurons in genetic and pharmacological models of typical absence seizures

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Figure 2GABA_BRs involvement in the tonic GABA_A current of TC neurons in genetic and pharmacological models of typical absence seizures