Figure 2, The input-output function of a pyramidal cell can be represented by the probability of neuronal firing plotted against the amplitude of the input (black curve) - Jasper's Basic Mechanisms of the Epilepsies

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Noebels JL, Avoli M, Rogawski MA, et al., editors. Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012.

This title is an author manuscript version first made accessible on the NCBI Bookshelf website July 2, 2012.

This title is an author manuscript version first made accessible on the NCBI Bookshelf website July 2, 2012.

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Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition.

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Figure 2The input-output function of a pyramidal cell can be represented by the probability of neuronal firing plotted against the amplitude of the input (black curve)

Synaptic noise reduces the gain (slope) of the input-output function because inputs that would otherwise be sub-threshold occasionally summate with positive membrane potential fluctuations, thus reaching firing threshold (red curve). Tonic currents, in contrast, predominantly affect offset, shifting the curve to the right (blue curve).

From: Tonic GABA_A Receptor-Mediated Signaling in Epilepsy

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Walker MC, Kullmann DM. Tonic GABAA Receptor-Mediated Signaling in Epilepsy. In: Noebels JL, Avoli M, Rogawski MA, et al., editors. Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012. Figure 2, The input-output function of a pyramidal cell can be represented by the probability of neuronal firing plotted against the amplitude of the input (black curve)
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Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition.

Figure 2The input-output function of a pyramidal cell can be represented by the probability of neuronal firing plotted against the amplitude of the input (black curve)

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