On December 4–5, 2019, the National Academies of Sciences, Engineering, and Medicine held a 1.5-day public workshop titled Exploring the Frontiers of Innovation to Tackle Microbial Threats. The workshop participants examined major advances in scientific, technological, and social innovations against microbial threats. Such innovations include diagnostics, vaccines (both development and production), and antimicrobials, as well as nonpharmaceutical interventions and changes in surveillance. This publication summarizes the presentations and discussions from the workshop.

Contents

• The National Academies of SCIENCES • ENGINEERING • MEDICINE
• PLANNING COMMITTEE ON EXPLORING THE FRONTIERS OF INNOVATION TO TACKLE MICROBIAL THREATS
• FORUM ON MICROBIAL THREATS
• Reviewers
• Acknowledgments
• Acronyms and Abbreviations
• 1. Introduction
  • WORKSHOP OBJECTIVES
  • ORGANIZATION OF THE PROCEEDINGS OF THE WORKSHOP
• 2. Pivotal Role of Innovations in Tackling Microbial Threats: Lessons from Past Outbreaks
  • LESSONS LEARNED FROM INNOVATION IN POLIO ERADICATION
  • ADVANCING INNOVATION ON THE GROUND IN THE FIGHT AGAINST EBOLA
  • DISCUSSION
• 3. Harnessing Lessons from Emerging Scientific, Technological, and Social Innovations
  • THE ROLE OF INNOVATION IN THE EVOLUTION OF GLOBAL VECTOR CONTROL RESPONSE
  • APPLYING MODELING TO INFORM INFECTIOUS DISEASE SURVEILLANCE AND OUTBREAK RESPONSE
  • UNBIASED METAGENOMICS SEQUENCING TO COUNTER MICROBIAL THREATS: LESSONS FROM BANGLADESH
  • DIGITAL PROCESS INNOVATIONS FOR HIV SELF-TESTING
  • DISCUSSION
• 4. Overcoming Barriers in the Field to Bolster Access and Practical Use of Innovations
  • DIGITAL INNOVATION TO IMPROVE IMMUNIZATION SERVICE DELIVERY
  • USING DATA AND MODELING TO IMPROVE DETECTION AND RESPONSE
  • OUTBREAK-RELATED DATA SHARING AND COLLABORATION: CHALLENGES AND OPPORTUNITIES
  • ADDRESSING HEALTH CHALLENGES WITH BEHAVIORIAL INSIGHTS AND TOOLS
  • DISCUSSION
• 5. Systems Approaches to Spur Innovations in Tackling Antimicrobial Resistance
  • APPLYING LESSONS FROM ONE HEALTH SURVEILLANCE TO TACKLE ANTIMICROBIAL RESISTANCE
  • SPARKING ANTIBIOTIC DISCOVERY THROUGH DATA SHARING AND SCIENTIFIC COLLABORATION
  • INCENTIVIZING NOVEL DIAGNOSTIC TESTS TO COUNTER ANTIBIOTIC RESISTANCE
  • STRENGTHENING SYSTEMS TO OVERCOME BARRIERS TO INNOVATION
  • DISCUSSION
• 6. Breaking Down Barriers and Fostering Partnerships to Enable Innovation
  • ENABLING BIOTECHNOLOGIES THROUGH PARTNERSHIPS
  • FOSTERING NEW PARTNERSHIPS TO ENABLE INNOVATION
  • PRIVATE-SECTOR PARTNERSHIPS TO ADDRESS GLOBAL HEALTH NEEDS
  • DISCUSSION
• 7. Nurturing Innovations Through Novel Ecosystems to Accelerate Research and Development
  • BIOMEDICAL ADVANCED RESEARCH AND DEVELOPMENT AUTHORITY
  • DECODING THE HUMAN IMMUNE SYSTEM TO TRANSFORM HUMAN HEALTH
  • REVERSE INNOVATION
  • NURTURING INNOVATION TO ACCELERATE RESEARCH AND DEVELOPMENT
  • SPURRING INNOVATION IN DIAGNOSTIC TOOLS
  • DISCUSSION
• 8. Visionary Statements on Priorities for Innovation
  • INNOVATIONS AGAINST VECTOR-BORNE DISEASES IN BRAZIL
  • INNOVATIONS TO ADDRESS ANTIMICROBIAL RESISTANCE IN CANADA
  • INNOVATIONS TO MAXIMIZE IMPACT IN AIDS, TUBERCULOSIS, AND MALARIA
  • FINAL SYNTHESIS AND DISCUSSION
• References
• Appendix A. Workshop Statement of Task
• Appendix B. Workshop Agenda
• Appendix C. Speaker Biographies

Suggested citation:

National Academies of Sciences, Engineering, and Medicine. 2020. Exploring the frontiers of innovation to tackle microbial threats: Proceedings of a workshop. Washington, DC: The National Academies Press. https://doi.org/10.17226/25746.

Digital Object Identifier: https://doi.org/10.17226/25746

Additional copies of this publication are available from the National Academies Press, 500 Fifth Street, NW, Keck 360, Washington, DC 20001; (800) 624-6242 or (202) 334-3313; http://www.nap.edu.

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