Structured Abstract

Contents

• Key Messages
• Preface
• Acknowledgments
• Key Informants
• Technical Expert Panel
• Peer Reviewers
• Evidence Summary
  • Introduction
  • Methods
  • Results
  • Discussion
  • Conclusion
  • References
• Chapter 1. Introduction
  • Background
  • Scope and Key Questions
• Chapter 2. Methods
  • Literature Search Strategy
  • Inclusion and Exclusion Criteria
  • Study Selection
  • Data Abstraction
  • Assessment of Methodological Risk of Bias of Individual Studies
  • Data Synthesis
  • Grading the Strength of Evidence
  • Assessing Applicability
• Chapter 3. Results
  • Literature Searches and Study Characteristics
  • KQ 1a. Benefits and Harms of Nonpharmacological Interventions
  • KQ 1b. Benefits and Harms of Nonpharmacological Interventions by Subpopulation
  • KQ 2a. Benefits and Harms of Pharmacological Interventions
  • KQ 2b. Benefits and Harms of Pharmacological Interventions by Subpopulation
  • KQ 3a. Benefits and Harms of Combination Interventions
  • KQ 3b. Benefits and Harms of Combination Interventions by Subpopulation
  • KQ 4a. Benefits and Harms of Collaborative Care Interventions
  • KQ 4b. Benefits and Harms of Collaborative Care Interventions by Subpopulation
  • KQ 5a. Comparative Benefits and Harms of Treatments
  • KQ 5b. Comparative Benefits and Harms of Treatments by Subpopulation
• Chapter 4. Discussion
  • Findings in Relation to What Is Already Known
  • Limitations
  • Applicability
  • Future Research Needs
  • Conclusion
• References
• Appendixes
  • Appendix A. Search Strategy
  • Appendix B. Inclusion/Exclusion Criteria
  • Appendix C. Excluded Studies
  • Appendix D. Study Characteristics
  • Appendix E. Evidence Tables
  • Appendix F. Harms Tables
  • Appendix G. Subpopulation Tables
  • Appendix H. Risk of Bias of Randomized Controlled Trials
  • Appendix I. Risk of Bias of Nonrandomized Controlled Trials
  • Appendix J. Meta-Analysis
  • Appendix K. Appendix References

Suggested citation:

Viswanathan M, Kennedy SM, McKeeman J, Christian R, Coker-Schwimmer M, Cook Middleton J, Bann C, Lux L, Randolph C, Forman-Hoffman V. Treatment of Depression in Children and Adolescents: A Systematic Review. Comparative Effectiveness Review No. 224. (Prepared by the RTI International–University of North Carolina at Chapel Hill Evidence-based Practice Center under Contract No. 290-2015-00011-I.) AHRQ Publication No. 20-EHC005-EF. Rockville, MD: Agency for Healthcare Research and Quality; April 2020. DOI: https://doi.org/10.23970/AHRQEPCCER224. Posted final reports are located on the Effective Health Care Program search page.

This report is based on research conducted by the RTI International–University of North Carolina at Chapel Hill Evidence-based Practice Center (EPC) under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. 290-2015-00011-I). The findings and conclusions in this document are those of the authors, who are responsible for its contents; the findings and conclusions do not necessarily represent the views of AHRQ. Therefore, no statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services.

None of the investigators have any affiliations or financial involvement that conflicts with the material presented in this report.

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