With contributions from more than 40 field specialists, Methods of Behavior Analysis in Neuroscience reflects six years of updates to its first bestselling edition and elucidates new behavioral approaches that are quickly becoming field standards.

This second edition features new material on the relevance of transgenic mouse models for Alzheimer's disease, behavioral methods for assessing the cognitive impairment associated with major psychotic disorders, the revival of the scopolamine reversal model for assessing the clinical relevance of new AD drugs, and new approaches to assessing the cognitive impairment in aged mice.

Contents

• Dedication
• Series Preface
• Preface
• The Editor
• Contributors
• 1. Transgenic Mouse Models of Alzheimer’s Disease: Behavioral Testing and Considerations
  Kathryn J. Bryan, Hyoung-gon Lee, George Perry, Mark A. Smith, and Gemma Casadesus.
  • 1.1 INTRODUCTION
  • 1.2 BEHAVIORAL TESTS
  • 1.3 TRANSGENIC MOUSE MODELS OF ALZHEIMER’S DISEASE
  • 1.4 CONCERNS WITH TRANSGENIC MOUSE MODELS OF ALZHEIMER’S DISEASE
  • REFERENCES
• 2. Cued and Contextual Fear Conditioning for Rodents
  Peter Curzon, Nathan R. Rustay, and Kaitlin E. Browman.
  • 2.1 INTRODUCTION
  • 2.2 CONTEXTUAL/CUED FEAR CONDITIONING: OVERVIEW
  • 2.3 BRAIN AREAS INVOLVED
  • 2.4 BEFORE GETTING STARTED
  • 2.5 SAMPLE EXPERIMENTS
  • 2.6 DATA ANALYSIS
  • 2.7 SAMPLE DATA
  • 2.8 NONASSOCIATIVE FREEZING COMPLICATIONS
  • 2.9 FINAL NOTE
  • 2.10 ADDENDUM
  • REFERENCES
• 3. Drug Discrimination
  Richard Young.
  • 3.1 INTRODUCTION
  • 3.2 METHODS
  • 3.3 DRUGS AS STIMULI
  • 3.4 APPLICATIONS
  • 3.5 SUMMARY
  • REFERENCES
• 4. Conditioned Place Preference
  Adam J. Prus, John R. James, and John A. Rosecrans.
  • 4.1 INTRODUCTION
  • 4.2 RESEARCH DESIGN AND METHODOLOGICAL CONSIDERATIONS
  • 4.3 TRAINING AND TESTING
  • 4.4 DRUG STUDIES USING THE CONDITIONED PLACE PREFERENCE PARADIGM
  • 4.5 THE MESOLIMBIC DOPAMINE SYSTEM IS IMPORTANT FOR CONDITIONED PLACE PREFERENCE
  • 4.6 MECHANISMS MEDIATING CONDITIONED PLACE PREFERENCE FOR COMMON DRUGS OF ABUSE
  • 4.7 CONDITIONED PLACE PREFERENCE VERSUS SELF-ADMINISTRATION
  • 4.8 SUMMARY
  • REFERENCES
• 5. Anxiety-Related Behaviors in Mice
  Kathleen R. Bailey and Jacqueline N. Crawley.
  • 5.1 INTRODUCTION
  • 5.2 GENERAL METHODOLOGICAL CONSIDERATIONS
  • 5.3 PARADIGMS
  • 5.4 CONCLUSION
  • REFERENCES
• 6. Behavioral Assessment of Antidepressant Activity in Rodents
  Vincent Castagné, Paul Moser, and Roger D. Porsolt.
  • 6.1 INTRODUCTION
  • 6.2 METHODS
  • 6.3 TYPICAL APPLICATIONS
  • 6.4 ANALYSIS AND INTERPRETATION
  • 6.5 REPRESENTATIVE DATA
  • 6.6 COMPARISON WITH RELATED PROCEDURES
  • REFERENCES
• 7. Assessing Attention in Rodents
  Philip J. Bushnell and Barbara J. Strupp.
  • 7.1 INTRODUCTION
  • 7.2 MULTIPLE-CHOICE SERIAL REACTION TIME TASKS
  • 7.3 SIGNAL DETECTION TASKS WITH BLANK TRIALS
  • 7.4 ATTENTIONAL SET-SHIFTING
  • 7.5 SELECTING A TEST METHOD
  • REFERENCES
  • APPENDIX: NAMES AND ADDRESSES OF VENDORS DISCUSSED IN THE TEXT
• 8. The Behavioral Assessment of Sensorimotor Processes in the Mouse: Acoustic Startle, Sensory Gating, Locomotor Activity, Rotarod, and Beam Walking
  Peter Curzon, Min Zhang, Richard J. Radek, and Gerard B. Fox.
  • 8.1 INTRODUCTION
  • 8.2 ACOUSTIC STARTLE
  • 8.3 SENSORY GATING
  • 8.4 MOTOR FUNCTION AND SPONTANEOUS EXPLORATION
  • REFERENCES
  • APPENDIX: EQUIPMENT SUPPLIERS
• 9. Intravenous Drug Self-Administration in Nonhuman Primates
  Leonard L. Howell and William E. Fantegrossi.
  • 9.1 INTRODUCTION
  • 9.2 SURGICAL PROCEDURES
  • 9.3 SCHEDULES OF REINFORCEMENT
  • 9.4 RESEARCH APPLICATION AND DATA INTERPRETATION
  • 9.5 DISCUSSION
  • REFERENCES
• 10. Contextually Induced Drug Seeking During Protracted Abstinence in Rats
  Jerry J. Buccafusco and Laura Shuster.
  • 10.1 INTRODUCTION
  • 10.2 GENERAL METHODS
  • 10.3 METHODOLOGICAL DETAILS
  • 10.4 ACTUAL DATA
  • 10.5 DISCUSSION
  • REFERENCES
• 11. Operant Analysis of Fronto-striatal Function in Rodents
  Máté D. Döbrössy, Simon Brooks, Rebecca Trueman, Peter J. Brasted, and Stephen B. Dunnett.
  • 11.1 INTRODUCTION
  • 11.2 THE NEUROPATHOLOGICAL AND BEHAVIORAL PROFILE OF HD
  • 11.3 ANIMAL MODELS OF HD
  • 11.4 OPERANT CONDITIONING AND OPERANT CHAMBERS
  • 11.5 OPERANT ANALYSIS OF MOTOR RESPONDING: STRIATAL LESIONED AND HD TRANSGENIC ANIMALS
  • 11.6 OPERANT ANALYSIS OF COGNITIVE TASKS: STRIATAL LESIONED AND GENETICALLY MODIFIED HD MODELS
  • 11.7 OPERANT ANALYSIS OF STRIATAL LESIONS: DEFICITS IN MOTIVATIONAL STATE
  • 11.18 CONCLUSION
  • REFERENCES
• 12. Working Memory Delayed Response Tasks in Monkeys
  Jesse S. Rodriguez and Merle G. Paule.
  • 12.1 INTRODUCTION
  • 12.2 METHODS
  • 12.3 DATA ANALYSIS AND INTERPRETATION
  • 12.4 TYPICAL APPLICATIONS
  • 12.5 REPRESENTATIVE DATA
  • 12.6 LIMITATIONS AND CONCLUSIONS
  • REFERENCES
• 13. Spatial Navigation (Water Maze) Tasks
  Alvin V. Terry Jr.
  • 13.1 INTRODUCTION
  • 13.2 STANDARD PROCEDURES
  • 13.3 ALTERNATIVE PROCEDURES
  • 13.4 SUMMARY AND CONCLUSIONS
  • REFERENCES
• 14. Water Maze Tasks in Mice: Special Reference to Alzheimer’s Transgenic Mice
  Dave Morgan.
  • 14.1 INTRODUCTION
  • 14.2 METHODS
  • 14.3 REPRESENTATIVE DATA
  • 14.4 ANALYSIS AND INTERPRETATION
  • REFERENCES
• 15. Behavioral Neuroscience of Zebrafish
  Edward D. Levin and Daniel T. Cerutti.
  • 15.1 INTRODUCTION
  • 15.2 USE OF FISH MODELS IN BEHAVIORAL NEUROSCIENCE
  • 15.3 PROCEDURES AND PROCESSES
  • 15.4 CONCLUSIONS
  • REFERENCES
• 16. Caenorhabditis elegans Model for Initial Screening and Mechanistic Evaluation of Potential New Drugs for Aging and Alzheimer’s Disease
  Yuan Luo, Yanjue Wu, Marishka Brown, and Christopher D. Link.
  • 16.1 INTRODUCTION
  • 16.2 METHODS
  • 16.3 TYPICAL APPLICATIONS
  • 16.4 ANALYSIS AND INTERPRETATION
  • 16.5 REPRESENTATIVE DATA
  • REFERENCES
• 17. The Revival of Scopolamine Reversal for the Assessment of Cognition-Enhancing Drugs
  Jerry J. Buccafusco.
  • 17.1 INTRODUCTION
  • 17.2 METHODS
  • 17.3 SCOPOLAMINE REVERSAL
  • 17.4 DISCUSSION
  • REFERENCES

Series editors: Sidney A Simon and Miguel AL Nicolelis

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