The book provides an up-to-date, concise, multidisciplinary overview of the epidemiology, pathology, and current evidence-based treatment options for patients with all stages of melanoma. These aspects are presented in two sections: epidemiology and pathophysiology, and therapy and management. In section 1, five chapters provide a comprehensive overview of the epidemiology, heterogeneity, and biology of melanoma. In section 2, six chapters discuss the various treatment options and surveillance recommendations for afflicted patients.

Contents

• Foreword
• Preface
• Contributors
• Section I. Epidemiology and Pathophysiology
  • 1. Epidemiology of Melanoma
    Natalie H. Matthews, Wen-Qing Li, Abrar A. Qureshi, Martin A. Weinstock, and Eunyoung Cho.
    • Introduction
    • Incidence
    • Mortality
    • Prevention
    • Conclusion
    • References
  • 2. The Epidemiology of Cutaneous Melanoma in the White and Black African Population Groups in South Africa
    Mary Norval and Caradee Y. Wright.
    • Introduction
    • South Africa
    • Incidence of CM in the White and Black African Population Groups
    • Body Sites and Subtypes of Melanoma in the White and Black African Population Groups
    • Risk Factors for Melanoma in South Africa
    • Stage of Melanoma at Diagnosis in the White and Black African Population Groups
    • Mortality Data for Melanoma in the White and Black African Population Groups
    • Conclusion
    • References
  • 3. Biomarkers in Malignant Melanoma: Recent Trends and Critical Perspective
    Birgit Belter, Cathleen Haase-Kohn, and Jens Pietzsch.
    • Introduction
    • Biomarkers in Malignant Melanoma: A Current Status
    • Conclusion
    • References
  • 4. Heterogeneity and Plasticity of Melanoma: Challenges of Current Therapies
    Mary J. C. Hendrix, Elisabeth A. Seftor, Naira V. Margaryan, and Richard E. B. Seftor.
    • Introduction
    • Melanoma Vascular Phenotype
    • Melanoma Embryonic Phenotype
    • Cancer Stem Cell Phenotype
    • Conclusion
    • References
  • 5. Ulcerated Melanoma: Aspects and Prognostic Impact
    Marie Louise Bønnelykke-Behrndtz and Torben Steiniche.
    • Introduction
    • Consumption of the Epidermis:A Possible Precursor of Ulceration That Associates with Increased Tumor Cell Proliferation
    • Melanomas with Re-Epithelialization and Reactive Epidermal Hyperplasia May Herald Late-Stage or Resolved Ulcerations
    • Ulceration Is a Heterogeneous Phenomenon of Which Both the Type and Extent Matters
    • The Extent of Ulceration and Changes of the Surrounding Epidermis Have a Prognostic Impact
    • Conclusion
    • References
• Section II. Therapy and Management
  • 6. Clinical Presentation and Staging of Melanoma
    William H. Ward, Fernando Lambreton, Neha Goel, Jian Q. Yu, and Jeffrey M. Farma.
    • Introduction
    • Screening Considerations
    • Clinical Diagnosis
    • Diagnostic Strategies
    • Melanoma Staging
    • Conclusion
    • References
  • 7. Surgical Management of Melanoma
    Kenneth M. Joyce.
    • Introduction
    • Surgical Treatment of Localized Disease
    • Clinically Negative Regional Lymph Nodes
    • Elective Lymph Node Dissection
    • Clinically Apparent Regional Lymph Nodes
    • In Transit Metastatic Disease
    • Surgical Treatment of Metastatic Melanoma
    • Conclusion
    • References
  • 8. Radiation Therapy for Melanoma
    Wenyin Shi.
    • Introduction
    • Historical Perspective
    • Definitive RT for Lentiginous Patients
    • RT in Mucosal Melanomas
    • Definitive RT for Ocular Melanomas
    • Adjuvant RT for Cutaneous Melanomas
    • Adjuvant RT for Regional Nodal Metastases
    • Role of Palliative RT for Melanomas
    • RT with Concomitant Agents
    • Perspectives and Conclusions
    • References
  • 9. Immune Checkpoint Inhibitors in the Treatment of Melanoma: From Basic Science to Clinical Application
    Matthew P. Rausch and Karen Taraszka Hastings.
    • Introduction
    • Biology of CTLA-4
    • Biology of PD-1
    • Biomarkers of Checkpoint Inhibitor Activity
    • Mechanisms of Resistance to Immune Checkpoint Blockade
    • Future Directions
    • Conclusion
    • References
  • 10. Nanomedicine in Melanoma: Current Trends and Future Perspectives
    Ayman El-Meghawry El-Kenawy, Carolina Constantin, Snur M. A. Hassan, Alshimaa Mohamed Mostafa, Adriana Freitas Neves, Thaise Gonçalves de Araújo, and Monica Neagu.
    • Introduction
    • Nanomedicine for Melanoma Detection and Treatment
    • Nano Therapies: Radiotherapy and Chemotherapy
    • Current Limitations and Exploring Possibilities for Improving the Efficiency of Nanodrugs in Melanoma
    • Conclusion
    • References
  • 11. Short-Term and Long-Term Management of Melanoma
    Neha Goel, William H. Ward, Jian Q. Yu, and Jeffrey M. Farma.
    • Introduction
    • Dermatological Surveillance
    • Laboratory Tests
    • Imaging
    • Conclusion
    • References

Cutaneous Melanoma: Etiology and Therapy

ISBN: 978-0-9944381-4-0

DOI: http://dx.doi.org/10.15586/codon.cutaneousmelanoma.2017

Edited by

William H. Ward, MD and Jeffrey M. Farma, MD

Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA

Published by

Codon Publications

Brisbane, QLD 4122, Australia

Copyright© 2017 Codon Publications

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First Published in November 2017

Printed in Australia

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