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This monograph evaluates the evidence of carcinogenicity of metallic cobalt particles with or without tungsten carbide, to which workers in the hard-metal industry are exposed, and of cobalt sulfate and other soluble cobalt (II) salts. It also evaluates three other particulate compounds: gallium arsenide and indium phosphide, which are used extensively in the microelectronics industry; and vanadium pentoxide, a contaminant at facilities refining and processing vanadium-rich ores and in various workplaces that use oil-fired boilers and furnaces.
Contents
- NOTE TO THE READER
- LIST OF PARTICIPANTS
- PREAMBLE
- GENERAL REMARKS ON THE SUBSTANCES CONSIDERED
- THE MONOGRAPHS
- LIST OF ABBREVIATIONS USED IN THIS VOLUME
- SUPPLEMENTARY CORRIGENDA TO VOLUMES 1–85
Corrigenda to the IARC Monographs are published online at: http://monographs.iarc.fr/ENG/Publications/corrigenda.php
LIBRARY CATALOGUING DATA
This publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 7–14 October 2003
Lyon, France - 2006
IARC MONOGRAPHS
In 1969, the International Agency for Research on Cancer (IARC) initiated a programme on the evaluation of the carcinogenic risk of chemicals to humans involving the production of critically evaluated monographs on individual chemicals. The programme was subsequently expanded to include evaluations of carcinogenic risks associated with exposures to complex mixtures, life-style factors and biological and physical agents, as well as those in specific occupations.
The objective of the programme is to elaborate and publish in the form of monographs critical reviews of data on carcinogenicity for agents to which humans are known to be exposed and on specific exposure situations; to evaluate these data in terms of human risk with the help of international working groups of experts in chemical carcinogenesis and related fields; and to indicate where additional research efforts are needed.
The lists of IARC evaluations are regularly updated and are available on Internet: http://monographs.iarc.fr/
This project was supported by Cooperative Agreement 5 UO1 CA33193 awarded by the United States National Cancer Institute, Department of Health and Human Services. Additional support has been provided since 1992 by the United States National Institute of Environmental Health Sciences.
This publication was made possible, in part, by a Cooperative Agreement between the United States Environmental Protection Agency, Office of Research and Development (USEPA-ORD) and the International Agency for Research on Cancer (IARC) and does not necessarily express the views of USEPA-ORD.
- Published by the International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France ©International Agency for Research on Cancer, 2006
- Distributed by WHO Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel.: +41 22 791 3264; fax: +41 22 791 4857; e-mail: tni.ohw@sredrokoob).
- Publications of the World Health Organization enjoy copyright protection in accordance with the provisions of Protocol 2 of the Universal Copyright Convention. All rights reserved.
- The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the World Health Organization concerning the legal status of any country, territory, city, or area or of its authorities, or concerning the delimitation of its frontiers or boundaries.
- The mention of specific companies or of certain manufacturers' products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.
- The authors alone are responsible for the views expressed in this publication.
- The International Agency for Research on Cancer welcomes requests for permission to reproduce or translate its publications, in part or in full. Requests for permission to reproduce or translate IARC publications – whether for sale or for noncommercial distribution – should be addressed to WHO Press, at the above address (fax: +41 22 791 4806; email: tni.ohw@snoissimrep).
IARC Library Cataloguing in Publication Data
- Cobalt in Hard Metals and Cobalt Sulfate, Gallium Arsenide, Indium Phosphide and Vanadium Pentoxide/IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2006 : Lyon, France)
- (IARC monographs on the evaluation of carcinogenic risks to humans ; v. 86)
- 1. Arsenic – adverse effects 2. Carcinogens 3. Cobalt – adverse effects 4. Gallium – adverse effects 5. Indium – adverse effects 6. Metals 7. Vanadium compounds – adverse effects 8. Tungsten – adverse effects I. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans II. Series
- ISBN 92 832 1286 X (NLM Classification: W1)
- ISSN 1017-1606
- PRINTED IN FRANCE
Cover: Some metallic compounds evaluated in this volume are used in integrated circuit boards which represent a new use of these metals.
Cover design by Georges Mollon, IARC
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