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The National Human Monitoring Program (NHMP) identifies concentrations of specific chemicals in human tissues, including toxicologic testing and risk assessment determinations. This volume evaluates the current activities of the NHMP; identifies important scientific, technical, and programmatic issues; and makes recommendations regarding the design of the program and use of its products.
Contents
- Committee on National Monitoring of Human Tissues
- Board on Environmental Studies and Toxicology
- Commission on Life Sciences
- Preface
- Executive Summary
- 1. Introduction
- 2. Review of the National Human Adipose Tissue Survey and Selected Program Alternatives
- 3. Toxicologic Issues
- 4. Sampling Methods
- INTRODUCTION
- SOME FEATURES FOR SAMPLING IN A CONTINUING POPULATION SURVEY
- COMMONLY REQUIRED COMPROMISES IN SAMPLING METHODS
- THE NATIONAL HUMAN ADIPOSE TISSUE SURVEY SAMPLE
- IMPROVEMENTS THAT ARE POSSIBLE WITHOUT CHANGING BASIC DATA COLLECTION METHODS
- COMPUTATION OF SAMPLING ERRORS
- CRITICISMS OF NHATS STATISTICAL SAMPLING METHODS
- SUMMARY AND RECOMMENDATIONS
- 5. Collection, Short-Term Storage, and Archiving of Tissues
- 6. Chemical Assay of Specimens
- 7. Program Design and Management Issues
- References
- Appendices
The project was supported by the U.S. Environmental Protection Agency through cooperative agreement No. CR-812547-01.
NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competencies and with regard for appropriate balance.
This report has been reviewed by a group other than the authors according to procedures approved by a Report Review Committee consisting of members of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine.
The National Academy of Sciences is a private, non-profit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that requires it to advise the federal government on scientific and technical matters. Dr. Frank Press is president of the National Academy of Sciences.
The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers. It is autonomous in its administration and in the selection of its members, sharing with the National Academy of Sciences the responsibility for advising the federal government. The National Academy of Engineering also sponsors engineering programs aimed at meeting national needs, encourages education and research, and recognizes the superior achievements of engineers. Dr. Robert M. White is president of the National Academy of Engineering.
The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public. The Institute acts under the responsibility given to the National Academy of Sciences by its congressional charter to be an adviser to the federal government and, upon its own initiative, to identify issues of medical care, research, and education. Dr. Samuel O.Thier is president of the Institute of Medicine.
The National Research Council was organized by the National Academy of Sciences in 1916 to associate the broad community of science and technology with the Academy's purposes of furthering knowledge and advising the federal government. Functioning in accordance with general policies determined by the Academy, the Council has become the principal operating agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, the public, and the scientific and engineering communities. The Council is administered jointly by both Academies and the Institute of Medicine. Dr. Frank Press and Dr. Robert M.White are chairman and vice chairman, respectively, of the National Research Council.
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