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Keith S, Faroon O, Roney N, et al. Toxicological Profile for Uranium. Atlanta (GA): Agency for Toxic Substances and Disease Registry (US); 2013 Feb.
Table 3-6Genotoxicity of Uranium In Vitro
| Species (test system) | End point | Results | Reference | |
|---|---|---|---|---|
| With activation | Without activation | |||
| Eukaryotic cells: | ||||
| Human osteosarcoma (HOS) cells (DU) | Micronucleus test | ND | + | Miller et al. 2002b, 2002c, 2003 |
| HOS cell line (DU) | Cell transformation | ND | + | Miller et al. 1998b, 2002b, 2002c |
| HOS cell line (DU) | Sister chromatid exchange | ND | + | Miller et al. 2002b |
| HOS cell line (DU) | DNA damage | ND | + | Miller et al. 2002b |
| Human bronchial fibroblasts (particulate DU) | Chromosomal aberrations | ND | + | Wise et al. 2007 |
| Human bronchial fibroblasts (soluble DU) | Chromosomal aberrations | ND | − | Wise et al. 2007 |
| Human bronchial epithelial cells (particulate DU) | Chromosomal aberrations | ND | + | LaCerte et al. 2010 |
| Mouse embryo fibroblast cell line (DU) | Micronucleus test | ND | + | Darolles et al. 2010 |
| CHO cells | Sister chromatid exchange | ND | + | Lin et al. 1993 |
| CHO cells | Chromosomal aberrations | ND | + | Lin et al. 1993 |
| CHO cells | Micronuclei | ND | + | Lin et al. 1993 |
| CHO EM9 cell line (DU) | Mutation at hprt locus | ND | ± | Stearns et al. 2005; Coryell and Stearns 2006 |
| CHO EM9 cell line (DU) | DNA damage; DNA adducts | ND | + | Stearns et al. 2005 |
| Rat kidney proximal cells (DU) | DNA damage | ND | + | Thiébault et al. 2007 |
| Rat kidney proximal cells (DU) | Micronuclei | ND | − | Thiébault et al. 2007 |
| Prokaryotic organisms: | ||||
| pBluescript SK+ plasmid from E. coli TOP10F’ (DU)a | DNA damage | ND | + | Yazzie et al. 2003 |
| Salmonella typhimurium TA98 (DU) | Reverse mutationb | ND | + | Miller et al. 1998a |
| Salmonella TA7001-7006 (DU) | Reverse mutationb | ND | + | Miller et al. 1998a |
| Salmonella TA98 (DU) | Reverse mutationc | ND | − | Miller et al. 1998a |
| Salmonella TA7001-7006 (DU) | Reverse mutationc | ND | − | Miller et al. 1998a |
- a
Incubated with ascorbate.
- b
Urine from rats implanted DU was tested.
- c
Serum from rats implanted DU was tested.
+ = positive result; ± = weakly positive; CHO = Chinese hamster ovary; DU = depleted uranium; ND = no data
- Table 3-6, Genotoxicity of Uranium In Vitro - Toxicological Profile for UraniumTable 3-6, Genotoxicity of Uranium In Vitro - Toxicological Profile for Uranium
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