NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Al-Khatib SM, Lapointe NA, Chatterjee R, et al. Treatment of Atrial Fibrillation [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013 Jun. (Comparative Effectiveness Reviews, No. 119.)
This publication is provided for historical reference only and the information may be out of date.
Table 12Comparisons of antiarrhythmic drugs for restoration of sinus rhythm
| Study | Sample Size (N) | Time Frame for Assessment | Restoration of SR pre-DCC (or Without DCC) | P Value | Restoration of SR Post-DCC | P value |
|---|---|---|---|---|---|---|
| Thomas, 2004149 | 140 | 12 hours | Amiodarone: 27/52 (52%) Sotalol: 20/45 (44%) Digoxin: 21/42 (50%) | NS | Amiodarone: 22/25 (88%) Sotalol: 23/25 (92%) Digoxin: 20/21 (95%) | NR |
| Vijayalakshmi, 2006181 | 94 | 6 weeks | Amiodarone: 7/27 (26%) Sotalol: 7/31 (23%) | 0.5 | Amiodarone: 15/20 (75%) Sotalol: 26/28 (93%) | NS |
| Joseph, 2000190 | 115 | 48 hours | Amiodarone: 30/39 (77%) Sotalol: 35/40 (88%) Digoxin: 21/36 (58%) | <0.01, sotalol vs. digoxin; NR between other drugs | NA | NA |
| Singh, 2005180 | 665 | 28 days | Amiodarone: 70/258 (27%) Sotalol: 59/244 (24%) | 0.45 | Amiodarone: 72% Sotalol: 74% | NR |
| Balla, 2011170 | 160 | 24 hours | Amiodarone: 85% Flecainide: 88% Propafenone: 85% | NS | NA | NA |
| Kafkas, 2007191 | 152 | 24 hours | Amiodarone: 42/73 (58%) Ibutilide: 63/79 (80%) | 0.005 | NA | NA |
| Korantzopoulos, 2006177 | 100 | 24 hours | Ibutilide: 21/51 (41%) Propafenone + ibutilide: 35/49 (84%) | 0.004 | NA | NA |
Abbreviations: DCC=direct current cardioversion; N=number of participants; NA=not applicable; NR=not reported; NS=not statistically significant; SR=sinus rhythm
- Table 12, Comparisons of antiarrhythmic drugs for restoration of sinus rhythm - ...Table 12, Comparisons of antiarrhythmic drugs for restoration of sinus rhythm - Treatment of Atrial Fibrillation
Your browsing activity is empty.
Activity recording is turned off.
See more...