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McCrory DC, Coeytaux RR, Schmit KM, et al. Pulmonary Arterial Hypertension: Screening, Management, and Treatment [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013 Apr. (Comparative Effectiveness Reviews, No. 117.)

  • This publication is provided for historical reference only and the information may be out of date.

This publication is provided for historical reference only and the information may be out of date.

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Pulmonary Arterial Hypertension: Screening, Management, and Treatment [Internet].

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Table 16Summary strength of evidence for KQ 1: TRV/VTIRVOT compared with RHC

ParameterNumber of Studies (Patients)DomainsStrength of Evidence
Effect Estimate (95% CI)
Risk of BiasConsistencyDirectnessPrecision
Sensitivity6 (196)ModerateConsistentIndirectPreciseSOE = Moderate
Range 89% to 100%
Echocardiographic estimate of PVR showed reasonably high sensitivity for ruling in PAH
Specificity6 (196)ModerateConsistentIndirectImpreciseSOE = Moderate
Range 50% to 97%
Echocardiographic estimate of PVR showed variable specificity, with better specificity in lower prevalence studies (range, 94% to 97%)
Correlation6 (196)LowConsistentIndirectPreciseSOE = High
Range 0.74 to 0.84
Strong correlation between echocardiographic estimates of PVR and PVR by RHC
Adverse effects0 (0)NANANANASOE = Insufficient
NA

CI = confidence interval; PAH = pulmonary arterial hypertension; PVR = pulmonary vascular resistance; RHC = right heart catheterization; SOE = strength of evidence; TRV = tricuspid regurgitant jet velocity; VTIRVOT = velocity-time integral of right ventricular outflow tract

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