Metabolomics-based targeted treatments RAD001 and CPI-613 were administered in INS-GAS mice for two months with or without pharmacological denervation using BoNT-A. Stomach samples were collected upon completed treatments and compared to controls.
The following contrasts are included:
INS-GAS mice (mouse GC) vs. Wild-Type mice (FVB)
INS-GAS mice (mouse GC) + BRC treatment vs. INS-GAS mice (mouse GC)
INS-GAS mice (mouse GC) + RC treatment vs. INS-GAS mice (mouse GC)
BRC; BoNT-A + RAD001 +CPI-613
RC: RAD001 + CPI-613 Less...