NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767951090|ref|XP_011542906|]
View 

cell cycle and apoptosis regulator protein 2 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DBC1 pfam14443
DBC1; DBC1 and it homologs from diverse eukaryotes are a catalytically inactive version of the ...
 300-417 1.28e-54

DBC1; DBC1 and it homologs from diverse eukaryotes are a catalytically inactive version of the Nudix hydrolase (MutT) domain. DBC1 is predicted to bind NAD metabolites and regulate the activity of SIRT1 or related deacetylases by sensing the soluble products or substrates of the NAD-dependent deacetylation reaction.


:

Pssm-ID: 464175  Cd Length: 123  Bit Score: 184.85  E-value: 1.28e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951090  300 EHPLKQIKFLLG--RKEEEAVLVGGEWSPSLDGLDPQADPQVLVRTAIRCAQAQTGIDLSGCTKWWRFAEFQYLQP---G 374
Cdd:pfam14443   1 VHPCKLLKFLVGdrGKDNEIMAIGGPWSPSLDGADPTTDPSVLIRTAIRTTKALTGIDLSNCTQWYRFAEVHYYRPktdG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 767951090  375 PPRRLQTVVVYLPDVWTIMPTLEEWEALCQQKAAEAAPPTQEA 417
Cdd:pfam14443  81 FPSRQEITVIFLPDVSSCLPSLEEWESLWLQYRKALLEKEREA 123
S1-like pfam14444
S1-like; S1-like RNA binding domain found in DBC1
 55-112 1.45e-32

S1-like; S1-like RNA binding domain found in DBC1


:

Pssm-ID: 464176  Cd Length: 58  Bit Score: 120.17  E-value: 1.45e-32
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767951090   55 QRVFTGIVTSLHDYFGVVDEEVFFQLSVVKGRLPQLGEKVLVKAAYNPGQAVPWNAVK 112
Cdd:pfam14444   1 QRVFTGVVTKLQDYFGFVDEDVFFQLSVVKGRLPQVGDRVLVEAVYNPNMPFKWNAQR 58
BURAN pfam19257
BURAN domain; This presumed domain is found exclusively in the CCAR1 protein.
 198-275 1.98e-17

BURAN domain; This presumed domain is found exclusively in the CCAR1 protein.


:

Pssm-ID: 466013  Cd Length: 82  Bit Score: 77.74  E-value: 1.98e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767951090  198 CDFLELQRRYRSLLVPSDFLSVHLSWLSAFPLSQPFSLHHPSRIQVSSEKEAAPDAGAEPITADSDPAYSSKVLLLSS 275
Cdd:pfam19257   5 RDYLELRKRYPRLYIPSDFSKLVLCWVETFPPLSPLPLDTPVSFHVMEKEVEPPLEQPAEAALEPADRYNAKVMLLSG 82
LAIKA pfam19256
LAIKA domain; This presumed domain is found exclusively in the CCAR1 protein.
 472-520 9.52e-15

LAIKA domain; This presumed domain is found exclusively in the CCAR1 protein.


:

Pssm-ID: 466012 [Multi-domain]  Cd Length: 68  Bit Score: 69.58  E-value: 9.52e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767951090  472 RPGCVNLSLHGIVEDRRP-KERISFEVMVLAELFLEMLQRDFGYRVYKML 520
Cdd:pfam19256  19 KFDCKSLSLDGLLDYREDdTKESTFEVSLFAELFHEMLQRDFGFTIYKAL 68
 
Name Accession Description Interval E-value
DBC1 pfam14443
DBC1; DBC1 and it homologs from diverse eukaryotes are a catalytically inactive version of the ...
 300-417 1.28e-54

DBC1; DBC1 and it homologs from diverse eukaryotes are a catalytically inactive version of the Nudix hydrolase (MutT) domain. DBC1 is predicted to bind NAD metabolites and regulate the activity of SIRT1 or related deacetylases by sensing the soluble products or substrates of the NAD-dependent deacetylation reaction.


Pssm-ID: 464175  Cd Length: 123  Bit Score: 184.85  E-value: 1.28e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951090  300 EHPLKQIKFLLG--RKEEEAVLVGGEWSPSLDGLDPQADPQVLVRTAIRCAQAQTGIDLSGCTKWWRFAEFQYLQP---G 374
Cdd:pfam14443   1 VHPCKLLKFLVGdrGKDNEIMAIGGPWSPSLDGADPTTDPSVLIRTAIRTTKALTGIDLSNCTQWYRFAEVHYYRPktdG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 767951090  375 PPRRLQTVVVYLPDVWTIMPTLEEWEALCQQKAAEAAPPTQEA 417
Cdd:pfam14443  81 FPSRQEITVIFLPDVSSCLPSLEEWESLWLQYRKALLEKEREA 123
S1-like pfam14444
S1-like; S1-like RNA binding domain found in DBC1
 55-112 1.45e-32

S1-like; S1-like RNA binding domain found in DBC1


Pssm-ID: 464176  Cd Length: 58  Bit Score: 120.17  E-value: 1.45e-32
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767951090   55 QRVFTGIVTSLHDYFGVVDEEVFFQLSVVKGRLPQLGEKVLVKAAYNPGQAVPWNAVK 112
Cdd:pfam14444   1 QRVFTGVVTKLQDYFGFVDEDVFFQLSVVKGRLPQVGDRVLVEAVYNPNMPFKWNAQR 58
BURAN pfam19257
BURAN domain; This presumed domain is found exclusively in the CCAR1 protein.
 198-275 1.98e-17

BURAN domain; This presumed domain is found exclusively in the CCAR1 protein.


Pssm-ID: 466013  Cd Length: 82  Bit Score: 77.74  E-value: 1.98e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767951090  198 CDFLELQRRYRSLLVPSDFLSVHLSWLSAFPLSQPFSLHHPSRIQVSSEKEAAPDAGAEPITADSDPAYSSKVLLLSS 275
Cdd:pfam19257   5 RDYLELRKRYPRLYIPSDFSKLVLCWVETFPPLSPLPLDTPVSFHVMEKEVEPPLEQPAEAALEPADRYNAKVMLLSG 82
LAIKA pfam19256
LAIKA domain; This presumed domain is found exclusively in the CCAR1 protein.
 472-520 9.52e-15

LAIKA domain; This presumed domain is found exclusively in the CCAR1 protein.


Pssm-ID: 466012 [Multi-domain]  Cd Length: 68  Bit Score: 69.58  E-value: 9.52e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767951090  472 RPGCVNLSLHGIVEDRRP-KERISFEVMVLAELFLEMLQRDFGYRVYKML 520
Cdd:pfam19256  19 KFDCKSLSLDGLLDYREDdTKESTFEVSLFAELFHEMLQRDFGFTIYKAL 68
 
Name Accession Description Interval E-value
DBC1 pfam14443
DBC1; DBC1 and it homologs from diverse eukaryotes are a catalytically inactive version of the ...
 300-417 1.28e-54

DBC1; DBC1 and it homologs from diverse eukaryotes are a catalytically inactive version of the Nudix hydrolase (MutT) domain. DBC1 is predicted to bind NAD metabolites and regulate the activity of SIRT1 or related deacetylases by sensing the soluble products or substrates of the NAD-dependent deacetylation reaction.


Pssm-ID: 464175  Cd Length: 123  Bit Score: 184.85  E-value: 1.28e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951090  300 EHPLKQIKFLLG--RKEEEAVLVGGEWSPSLDGLDPQADPQVLVRTAIRCAQAQTGIDLSGCTKWWRFAEFQYLQP---G 374
Cdd:pfam14443   1 VHPCKLLKFLVGdrGKDNEIMAIGGPWSPSLDGADPTTDPSVLIRTAIRTTKALTGIDLSNCTQWYRFAEVHYYRPktdG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 767951090  375 PPRRLQTVVVYLPDVWTIMPTLEEWEALCQQKAAEAAPPTQEA 417
Cdd:pfam14443  81 FPSRQEITVIFLPDVSSCLPSLEEWESLWLQYRKALLEKEREA 123
S1-like pfam14444
S1-like; S1-like RNA binding domain found in DBC1
 55-112 1.45e-32

S1-like; S1-like RNA binding domain found in DBC1


Pssm-ID: 464176  Cd Length: 58  Bit Score: 120.17  E-value: 1.45e-32
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767951090   55 QRVFTGIVTSLHDYFGVVDEEVFFQLSVVKGRLPQLGEKVLVKAAYNPGQAVPWNAVK 112
Cdd:pfam14444   1 QRVFTGVVTKLQDYFGFVDEDVFFQLSVVKGRLPQVGDRVLVEAVYNPNMPFKWNAQR 58
BURAN pfam19257
BURAN domain; This presumed domain is found exclusively in the CCAR1 protein.
 198-275 1.98e-17

BURAN domain; This presumed domain is found exclusively in the CCAR1 protein.


Pssm-ID: 466013  Cd Length: 82  Bit Score: 77.74  E-value: 1.98e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767951090  198 CDFLELQRRYRSLLVPSDFLSVHLSWLSAFPLSQPFSLHHPSRIQVSSEKEAAPDAGAEPITADSDPAYSSKVLLLSS 275
Cdd:pfam19257   5 RDYLELRKRYPRLYIPSDFSKLVLCWVETFPPLSPLPLDTPVSFHVMEKEVEPPLEQPAEAALEPADRYNAKVMLLSG 82
LAIKA pfam19256
LAIKA domain; This presumed domain is found exclusively in the CCAR1 protein.
 472-520 9.52e-15

LAIKA domain; This presumed domain is found exclusively in the CCAR1 protein.


Pssm-ID: 466012 [Multi-domain]  Cd Length: 68  Bit Score: 69.58  E-value: 9.52e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767951090  472 RPGCVNLSLHGIVEDRRP-KERISFEVMVLAELFLEMLQRDFGYRVYKML 520
Cdd:pfam19256  19 KFDCKSLSLDGLLDYREDdTKESTFEVSLFAELFHEMLQRDFGFTIYKAL 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH