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Conserved domains on  [gi|578809946|ref|XP_006714547|]
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prolactin receptor isoform X2 [Homo sapiens]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10414115)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 24-120 3.91e-30

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam09067:

Pssm-ID: 473895  Cd Length: 104  Bit Score: 114.06  E-value: 3.91e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809946   24 GQLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMhECPDYITGGPNS-----CHFGKQYTSMWRT 98
Cdd:pfam09067   4 ALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENETVK-ECPLYSTSGANStrlfiCFFPKNDVSLFVP 82

                          90       100
                  ....*....|....*....|..
gi 578809946   99 YIMMVNATNQMGSSFSDELYVD 120
Cdd:pfam09067  83 LHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 127-225 1.80e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 1.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809946 127 PDPPLELAVEVKQPEdrkpYLWIKWSPPTlidlKTGWFTLLYEIRLKPEKAAEWEI--HFAGQQTEFKILSLHPGQKYLV 204
Cdd:cd00063    1 PSPPTNLRVTDVTST----SVTLSWTPPE----DDGGPITGYVVEYREKGSGDWKEveVTPGSETSYTLTGLKPGTEYEF 72

                         90       100
                 ....*....|....*....|.
gi 578809946 205 QVRCKPDHGyWSAWSPATFIQ 225
Cdd:cd00063   73 RVRAVNGGG-ESPPSESVTVT 92
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 24-120 3.91e-30

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 114.06  E-value: 3.91e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809946   24 GQLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMhECPDYITGGPNS-----CHFGKQYTSMWRT 98
Cdd:pfam09067   4 ALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENETVK-ECPLYSTSGANStrlfiCFFPKNDVSLFVP 82

                          90       100
                  ....*....|....*....|..
gi 578809946   99 YIMMVNATNQMGSSFSDELYVD 120
Cdd:pfam09067  83 LHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 127-225 1.80e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 1.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809946 127 PDPPLELAVEVKQPEdrkpYLWIKWSPPTlidlKTGWFTLLYEIRLKPEKAAEWEI--HFAGQQTEFKILSLHPGQKYLV 204
Cdd:cd00063    1 PSPPTNLRVTDVTST----SVTLSWTPPE----DDGGPITGYVVEYREKGSGDWKEveVTPGSETSYTLTGLKPGTEYEF 72

                         90       100
                 ....*....|....*....|.
gi 578809946 205 QVRCKPDHGyWSAWSPATFIQ 225
Cdd:cd00063   73 RVRAVNGGG-ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 127-214 6.25e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.31  E-value: 6.25e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809946   127 PDPPLELAVEVKQPEdrkpYLWIKWSPPTliDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYLVQV 206
Cdd:smart00060   1 PSPPSNLRVTDVTST----SVTLSWEPPP--DDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74


                   ....*...
gi 578809946   207 RCKPDHGY 214
Cdd:smart00060  75 RAVNGAGE 82
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
97-248 1.32e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 48.07  E-value: 1.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809946  97 RTYIMMVNATNQMG--SSFSDELYVdVTYIVQPDPPLELAVEVKqpEDRKPYLwiKWSPPTLIDLKTgwftllYEIRLKP 174
Cdd:COG3401  296 TTYYYRVTAVDAAGneSAPSNVVSV-TTDLTPPAAPSGLTATAV--GSSSITL--SWTASSDADVTG------YNVYRST 364

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578809946 175 EKAAEWE-IHFAGQQTEFKILSLHPGQKYLVQVRCKPDHGYWSAWSPATFIQIPSDFTMNDTTVWISVAVLSAVI 248
Cdd:COG3401  365 SGGGTYTkIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVA 439
fn3 pfam00041
Fibronectin type III domain;
128-219 3.60e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 39.71  E-value: 3.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809946  128 DPPLELAVEVKQPEdrkpYLWIKWSPPTLIDLK-TGwftllYEIRLKPEKAAEWEIHF--AGQQTEFKILSLHPGQKYLV 204
Cdd:pfam00041   1 SAPSNLTVTDVTST----SLTVSWTPPPDGNGPiTG-----YEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEV 71

                          90
                  ....*....|....*
gi 578809946  205 QVRCKPDHGyWSAWS 219
Cdd:pfam00041  72 RVQAVNGGG-EGPPS 85
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 24-120 3.91e-30

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 114.06  E-value: 3.91e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809946   24 GQLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMhECPDYITGGPNS-----CHFGKQYTSMWRT 98
Cdd:pfam09067   4 ALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENETVK-ECPLYSTSGANStrlfiCFFPKNDVSLFVP 82

                          90       100
                  ....*....|....*....|..
gi 578809946   99 YIMMVNATNQMGSSFSDELYVD 120
Cdd:pfam09067  83 LHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 127-225 1.80e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 1.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809946 127 PDPPLELAVEVKQPEdrkpYLWIKWSPPTlidlKTGWFTLLYEIRLKPEKAAEWEI--HFAGQQTEFKILSLHPGQKYLV 204
Cdd:cd00063    1 PSPPTNLRVTDVTST----SVTLSWTPPE----DDGGPITGYVVEYREKGSGDWKEveVTPGSETSYTLTGLKPGTEYEF 72

                         90       100
                 ....*....|....*....|.
gi 578809946 205 QVRCKPDHGyWSAWSPATFIQ 225
Cdd:cd00063   73 RVRAVNGGG-ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 127-214 6.25e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.31  E-value: 6.25e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809946   127 PDPPLELAVEVKQPEdrkpYLWIKWSPPTliDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYLVQV 206
Cdd:smart00060   1 PSPPSNLRVTDVTST----SVTLSWEPPP--DDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74


                   ....*...
gi 578809946   207 RCKPDHGY 214
Cdd:smart00060  75 RAVNGAGE 82
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
97-248 1.32e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 48.07  E-value: 1.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809946  97 RTYIMMVNATNQMG--SSFSDELYVdVTYIVQPDPPLELAVEVKqpEDRKPYLwiKWSPPTLIDLKTgwftllYEIRLKP 174
Cdd:COG3401  296 TTYYYRVTAVDAAGneSAPSNVVSV-TTDLTPPAAPSGLTATAV--GSSSITL--SWTASSDADVTG------YNVYRST 364

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578809946 175 EKAAEWE-IHFAGQQTEFKILSLHPGQKYLVQVRCKPDHGYWSAWSPATFIQIPSDFTMNDTTVWISVAVLSAVI 248
Cdd:COG3401  365 SGGGTYTkIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVA 439
fn3 pfam00041
Fibronectin type III domain;
128-219 3.60e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 39.71  E-value: 3.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809946  128 DPPLELAVEVKQPEdrkpYLWIKWSPPTLIDLK-TGwftllYEIRLKPEKAAEWEIHF--AGQQTEFKILSLHPGQKYLV 204
Cdd:pfam00041   1 SAPSNLTVTDVTST----SLTVSWTPPPDGNGPiTG-----YEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEV 71

                          90
                  ....*....|....*
gi 578809946  205 QVRCKPDHGyWSAWS 219
Cdd:pfam00041  72 RVQAVNGGG-EGPPS 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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