NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|7705885|ref|NP_057292|]
View 

vacuolar protein sorting-associated protein 28 homolog isoform 1 [Homo sapiens]

Protein Classification

ESCRT-I complex subunit VPS28( domain architecture ID 10512640)

ESCRT-I complex subunit VPS28 (vacuolar protein sorting-associated protein 28) is a component of the endosomal sorting complex required for transport I, which is a regulator of vesicular trafficking processes

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
VPS28 pfam03997
VPS28 protein;
39-219 3.18e-101

VPS28 protein;


:

Pssm-ID: 427639  Cd Length: 187  Bit Score: 290.95  E-value: 3.18e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705885     39 MAELFAVVKTMQALEKAYIKDCVSPSEYTAACSRLLVQYKAAFRQVQGSEISSIDEFCRKFRLDCPLAMERIKEDRPITI 118
Cdd:pfam03997   1 LAELYSIIVTLEHLEKAYIKDSITAKEYTSTCSRLLAQYKTILDELVKDEFPDLEEFMKKYRLDCPAALERLREGVPATV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705885    119 KD------DKGNLNRCIADVVSLFITVMDKLRLEIRAMDEIQPDLRELMETMHRMSHLPPDFEGRQTVSQWLQTLSGMSA 192
Cdd:pfam03997  81 EHsasssaDGGNSAKLVAEATQNFITLMDALKLNYRAKDQLHPLLSDLLQSLNKLSLLPPDFEGKSKLVKWLIKLNNMKA 160

                         170       180
                  ....*....|....*....|....*..
gi 7705885    193 SDELDDSQVRQMLFDLESAYNAFNRFL 219
Cdd:pfam03997 161 SDELSEEQARQLLFDLESAYNAFYRSL 187
 
Name Accession Description Interval E-value
VPS28 pfam03997
VPS28 protein;
39-219 3.18e-101

VPS28 protein;


Pssm-ID: 427639  Cd Length: 187  Bit Score: 290.95  E-value: 3.18e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705885     39 MAELFAVVKTMQALEKAYIKDCVSPSEYTAACSRLLVQYKAAFRQVQGSEISSIDEFCRKFRLDCPLAMERIKEDRPITI 118
Cdd:pfam03997   1 LAELYSIIVTLEHLEKAYIKDSITAKEYTSTCSRLLAQYKTILDELVKDEFPDLEEFMKKYRLDCPAALERLREGVPATV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705885    119 KD------DKGNLNRCIADVVSLFITVMDKLRLEIRAMDEIQPDLRELMETMHRMSHLPPDFEGRQTVSQWLQTLSGMSA 192
Cdd:pfam03997  81 EHsasssaDGGNSAKLVAEATQNFITLMDALKLNYRAKDQLHPLLSDLLQSLNKLSLLPPDFEGKSKLVKWLIKLNNMKA 160

                         170       180
                  ....*....|....*....|....*..
gi 7705885    193 SDELDDSQVRQMLFDLESAYNAFNRFL 219
Cdd:pfam03997 161 SDELSEEQARQLLFDLESAYNAFYRSL 187
 
Name Accession Description Interval E-value
VPS28 pfam03997
VPS28 protein;
39-219 3.18e-101

VPS28 protein;


Pssm-ID: 427639  Cd Length: 187  Bit Score: 290.95  E-value: 3.18e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705885     39 MAELFAVVKTMQALEKAYIKDCVSPSEYTAACSRLLVQYKAAFRQVQGSEISSIDEFCRKFRLDCPLAMERIKEDRPITI 118
Cdd:pfam03997   1 LAELYSIIVTLEHLEKAYIKDSITAKEYTSTCSRLLAQYKTILDELVKDEFPDLEEFMKKYRLDCPAALERLREGVPATV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705885    119 KD------DKGNLNRCIADVVSLFITVMDKLRLEIRAMDEIQPDLRELMETMHRMSHLPPDFEGRQTVSQWLQTLSGMSA 192
Cdd:pfam03997  81 EHsasssaDGGNSAKLVAEATQNFITLMDALKLNYRAKDQLHPLLSDLLQSLNKLSLLPPDFEGKSKLVKWLIKLNNMKA 160

                         170       180
                  ....*....|....*....|....*..
gi 7705885    193 SDELDDSQVRQMLFDLESAYNAFNRFL 219
Cdd:pfam03997 161 SDELSEEQARQLLFDLESAYNAFYRSL 187
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH